Gene: GDF15

9518
GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB
growth differentiation factor 15
protein-coding
19p13.11
Ensembl:ENSG00000130513 MIM:605312 Vega:OTTHUMG00000183360 UniprotKB:Q99988
NC_000019.10
PubMed
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.697e-1 (AD)  4.652e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCRL20.725
ICAM10.716
APOL30.698
TRIM50.698
PARP120.697
SP1000.697
TNFAIP30.692
STX110.692
VCAM10.69
HELZ20.688

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASIC2-0.447
MYADML2-0.438
CHRNB2-0.434
TMEM179-0.434
SLC7A4-0.427
HRH3-0.418
OMG-0.417
DNAJC28-0.417
ZNF835-0.417
GABRA5-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of GDF15 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of GDF15 mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of GDF15 mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GDF15 mRNA"19850644|2135444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GDF15 mRNA]"19850644
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]22410117
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of GDF15 protein]14662774
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GDF15 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GDF15 mRNA"21346803
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]14662774
C0194992-nitrofluorene2-nitrofluorene results in increased expression of GDF15 mRNA14600272|1589037
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of GDF15 mRNA"15670751
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of GDF15 mRNA"20638727
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GDF15 mRNA"19692669
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of GDF15 mRNA"24172598
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of GDF15 mRNA18544908
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]21097678
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]21097678
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of GDF15 mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GDF15 mRNA14600272|1589037
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of GDF15 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of GDF15 mRNA"28073004
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of GDF15 mRNA"26238291
C0371129-deoxy-delta-9-prostaglandin D2[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]14662774
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 mRNA14662774
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein14662774
C056498aceclofenacaceclofenac results in increased expression of GDF15 protein15555568
C056498aceclofenacaceclofenac results in increased expression of GDF15 mRNA18076062
D000082AcetaminophenAcetaminophen results in increased expression of GDF15 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GDF15 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of GDF15 mRNA18544908|2605643
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of GDF15 mRNA28959563
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of GDF15 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GDF15 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GDF15 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GDF15 mRNA14600272|1589037
D000393Air PollutantsAir Pollutants analog results in increased expression of GDF15 mRNA21757418
D000447AldehydesAldehydes results in increased expression of GDF15 mRNA25014914
C103303alitretinoinalitretinoin results in increased expression of GDF15 mRNA15982314
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of GDF15 mRNA16523695
C068073Am 580Am 580 results in increased expression of GDF15 mRNA16982809
D000638AmiodaroneAmiodarone results in increased expression of GDF15 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GDF15 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of GDF15 mRNA"22863853
D001115ArecolineArecoline results in increased expression of GDF15 mRNA17682004
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GDF15 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GDF15 mRNA23912714
D001149ArsenatesArsenates results in decreased expression of GDF15 mRNA12773770
D001151ArsenicArsenic results in decreased expression of GDF15 mRNA12773770
C006632arsenic trioxidearsenic trioxide results in increased expression of GDF15 mRNA19036111|2525818
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of GDF15 protein"20855422
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GDF15 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GDF15 mRNA"18687144
D001241AspirinAspirin results in increased expression of GDF15 mRNA14976132
D001241AspirinAspirin results in increased expression of GDF15 protein15180942
D001280AtrazineAtrazine results in increased expression of GDF15 mRNA22378314
C017037aurinaurin results in increased expression of GDF15 mRNA25477506
D001379AzathioprineAzathioprine results in increased expression of GDF15 mRNA22623647
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GDF15 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of GDF15 mRNA19737606
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of GDF15 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GDF15 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GDF15 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GDF15 mRNA"19150397|2038263
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA]25566086
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of GDF15 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of GDF15 mRNA19167446
D004958EstradiolEstradiol results in increased expression of GDF15 mRNA19619570|2010694
D004958EstradiolEstradiol results in increased expression of GDF15 mRNA25210133
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid affects the expression of GDF15 mRNA18192240
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of GDF15 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of GDF15 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of GDF15 mRNA25047013|2768578
C006780bisphenol Abisphenol A results in increased secretion of GDF15 protein27745655
C006780bisphenol Abisphenol A results in increased expression of GDF15 mRNA25181051
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of GDF15 mRNA25522274
D000069286BortezomibBortezomib results in increased expression of GDF15 mRNA20830808
C016274bromoacetatebromoacetate results in increased expression of GDF15 mRNA19753638
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GDF15 mRNA22079614
D001973Bromodeoxyuridine[Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA24910943
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GDF15 mRNA12414654
C018475butyraldehydebutyraldehyde results in increased expression of GDF15 mRNA26079696
C584509C646 compoundC646 compound affects the expression of GDF15 mRNA26191083
C584509C646 compoundC646 compound results in increased expression of GDF15 mRNA26921506
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GDF15 mRNA25596134
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride affects the expression of GDF15 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GDF15 mRNA19010381
D002185CannabidiolCannabidiol results in increased expression of GDF15 mRNA21542829
D002211CapsaicinATF3 mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]20110283
D002211CapsaicinCapsaicin results in increased expression of GDF15 mRNA20110283
D002211CapsaicinCapsaicin results in increased phosphorylation of GDF15 protein20110283
D002211CapsaicinCEBPB mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]20110283
D002211Capsaicin[CEBPB protein binds to GDF15 promoter] promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]20110283|2011028
D002211CapsaicinCEBPB protein promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]20110283
D002211CapsaicinGSK3B mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]20110283
D002220CarbamazepineCarbamazepine affects the expression of GDF15 mRNA25979313
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of GDF15 mRNA16039398
D002392CatechinCatechin results in increased expression of GDF1524440808
D000068579Celecoxib[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA17959037
D000068579CelecoxibCelecoxib results in increased expression of GDF1517257745
D000068579CelecoxibCelecoxib results in increased expression of GDF15 mRNA17959037|1808984
D000068579CelecoxibGSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]17257745
D000068579CelecoxibPTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]18089846
D000068579CelecoxibSB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]17257745
D002509CephaloridineCephaloridine results in decreased expression of GDF15 mRNA18500788
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of GDF15 mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GDF15 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of GDF15 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of GDF15 mRNA23125180
D002746ChlorpromazineChlorpromazine results in increased expression of GDF15 mRNA25596134
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA12634122
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GDF15 mRNA28472532
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA12634122
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA27858113
C031180chrysenechrysene results in decreased expression of GDF15 mRNA26377693
C059262cidofovircidofovir results in increased expression of GDF15 mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of GDF15 mRNA18353800
D004002Clodronic AcidClodronic Acid results in decreased expression of GDF15 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA]17585979
D003033Coal TarCoal Tar results in increased expression of GDF15 mRNA27858113
D003035Cobalt[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of GDF15 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of GDF15 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of GDF15 mRNA24386269
D003078ColchicineColchicine results in decreased expression of GDF15 mRNA24211769
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of GDF15 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of GDF15 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GDF15 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of GDF15 mRNA19167446
C402665CP 31398CP 31398 results in increased expression of GDF15 mRNA15155752
C024015cryptolepinecryptolepine results in increased expression of GDF15 mRNA16120219
C030973cupric oxidecupric oxide results in increased expression of GDF15 mRNA22077320
D003513CycloheximideCycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 mRNA]18801729
D003513CycloheximideCycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 protein]18801729
D003513CycloheximideCycloheximide inhibits the reaction [troglitazone results in increased expression of GDF15 mRNA]14662774
D016572CyclosporineCyclosporine results in increased expression of GDF15 mRNA19159671|2010694
C089595cylindrospermopsincylindrospermopsin results in increased expression of GDF15 mRNA23726867|2492166
D003609DactinomycinDactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA]17257620
C515055darinaparsindarinaparsin results in decreased expression of GDF15 mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of GDF15 mRNA]22535156
D003630DaunorubicinDaunorubicin results in increased expression of GDF15 mRNA26537877|2894005
C014347decitabinedecitabine affects the expression of GDF15 mRNA17145863|2330084
C014347decitabinedecitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 mRNA]18801729|1880172
C014347decitabinedecitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 protein]18801729|1880172
C014347decitabinedecitabine results in increased expression of GDF15 mRNA27915011
D013759DronabinolDronabinol results in decreased expression of GDF15 mRNA16039398
D013759DronabinolDronabinol results in increased expression of GDF15 mRNA16039398
D013759DronabinolDronabinol results in increased expression of GDF15 mRNA21542829
D003703DemecolcineDemecolcine results in increased expression of GDF15 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of GDF15 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of GDF15 mRNA22733784
C028009diallyl disulfidediallyl disulfide results in increased expression of GDF15 protein11925476
C028009diallyl disulfideTP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]11925476
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GDF15 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GDF15 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GDF15 mRNA28962523
D002945CisplatinCisplatin affects the expression of GDF15 mRNA23300844
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of GDF15 mRNA]21858171
D002945CisplatinCisplatin results in increased expression of GDF15 mRNA21532991|2421176
D002945CisplatinFolic Acid affects the reaction [Cisplatin affects the expression of GDF15 mRNA]16898872
D002945CisplatinCisplatin results in increased expression of GDF15 mRNA21151649
D004008DiclofenacDiclofenac results in increased expression of GDF15 protein15555568
D004008DiclofenacDiclofenac results in increased expression of GDF15 mRNA18076062
C000944dicrotophosdicrotophos results in increased expression of GDF15 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GDF15 mRNA19850644
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GDF15 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GDF15 mRNA19100860|2160768
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GDF15 mRNA15890375
D002117CalcitriolCalcitriol results in increased expression of GDF15 mRNA15386353|1652369
D002117CalcitriolCalcitriol results in increased expression of GDF15 protein15386353
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of GDF15 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GDF15 mRNA14600272|1589037
D004237DiuronDiuron metabolite results in increased expression of GDF15 mRNA24172598
D004237DiuronDiuron results in increased expression of GDF15 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of GDF15 mRNA16705698
D004317DoxorubicinDoxorubicin results in increased expression of GDF15 mRNA15205334|2552947
D004317DoxorubicinGDF15 protein results in decreased susceptibility to Doxorubicin22615612
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of GDF15 mRNA"23811387
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of GDF15 mRNA15528975
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in increased expression of GDF15 mRNA15528975
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA26159488
C118739entinostatentinostat results in increased expression of GDF15 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
D000431EthanolEthanol results in increased expression of GDF15 mRNA28986285
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GDF15 mRNA23649840|2421176
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of GDF15 mRNA19100860
D005047EtoposideEtoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]11895857|1189585
D005047EtoposideEtoposide results in increased expression of GDF15 mRNA16120219|2421176
D005047EtoposideEtoposide results in increased expression of GDF15 protein11895857
D005047Etoposide[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein11895857
C540355fenamidonefenamidone results in increased expression of GDF15 mRNA27029645
D011345FenofibrateFenofibrate results in increased expression of GDF15 mRNA25596134
D011345FenofibrateFenofibrate results in increased expression of GDF15 mRNA25596134
C024352fludarabinefludarabine results in increased expression of GDF15 mRNA16439677
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GDF15 mRNA21607683
D005472FluorouracilFluorouracil results in increased expression of GDF15 mRNA15205334
D005472FluorouracilFluorouracil results in increased expression of GDF15 protein14665630
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of GDF15 mRNA]15016801
D005480Flurbiprofen4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]21097678
D005480FlurbiprofenFlurbiprofen results in increased expression of GDF15 protein21097678
D005480FlurbiprofenMAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]21097678
D005480FlurbiprofenNGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]21097678
D005485FlutamideFlutamide results in increased expression of GDF15 mRNA24793618
D005492Folic AcidFolic Acid affects the reaction [Cisplatin affects the expression of GDF15 mRNA]16898872
D005557FormaldehydeFormaldehyde results in decreased expression of GDF15 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of GDF15 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of GDF15 mRNA19167457
C039281furan[Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA24910943
C039281furanfuran results in increased expression of GDF15 mRNA24183702|2491094
C039281furanfuran results in decreased expression of GDF15 mRNA26194646
C039281furanfuran results in increased methylation of GDF15 gene22079235
C106014geduningedunin results in increased expression of GDF15 mRNA17010675
D019833GenisteinGenistein results in decreased expression of GDF15 mRNA20884965
D019833GenisteinGenistein results in increased expression of GDF15 mRNA22228119|2686566
D019833GenisteinGenistein results in increased expression of GDF15 mRNA16169203
D019833GenisteinGenistein results in increased expression of GDF1524440808
D005839GentamicinsGentamicins results in decreased expression of GDF15 mRNA22061828
C007845gingerolgingerol results in increased expression of GDF15 mRNA18058799
C007845gingerolgingerol results in increased expression of GDF15 protein18058799
C007845gingerolGSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]18058799
C007845gingerolPRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]18058799
C007845gingerolRo 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]18058799
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of GDF15 mRNA16206274
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]23996089
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]23996089
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]23996089
D017313FenretinideFenretinide results in increased expression of GDF15 mRNA15958647|1667109
D017313FenretinideFenretinide results in increased expression of GDF15 protein15958647
D017313FenretinideFenretinide results in increased expression of GDF15 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GDF15 mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GDF1518687144
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GDF15 mRNA12414654|1545976
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GDF15 protein15459768
C031927hydroquinonehydroquinone results in increased expression of GDF15 mRNA23416264
D006918HydroxyureaHydroxyurea results in increased expression of GDF15 mRNA24211769
D007052Ibuprofen4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]21097678
D007052IbuprofenIbuprofen results in increased expression of GDF15 mRNA25596134
D007052IbuprofenIbuprofen results in increased expression of GDF15 protein15555568|2109767
D007052IbuprofenMAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]21097678
D007052IbuprofenNGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]21097678
C492448ICG 001ICG 001 results in increased expression of GDF15 mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of GDF15 mRNA25596134
C016517indole-3-carbinol[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF1515670751
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GDF1515670751
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GDF1524440808
D007213IndomethacinGDF15 protein results in decreased susceptibility to Indomethacin22615612
D007213IndomethacinIndomethacin results in increased expression of GDF15 mRNA15509713|1698473
D007213IndomethacinIndomethacin results in increased expression of GDF15 protein15180942|1550971
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of GDF15 mRNA18076062
C051890irinotecanirinotecan metabolite results in increased expression of GDF15 mRNA15956246
C051890irinotecanirinotecan results in increased expression of GDF15 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA28628672
C057531jasplakinolidejasplakinolide results in increased expression of GDF15 mRNA23996089
C057531jasplakinolidejasplakinolide results in increased expression of GDF15 protein23996089
C057531jasplakinolide[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]23996089
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GDF15 mRNA24796395
C410337K 7174K 7174 results in increased expression of GDF15 mRNA24086573
C410337K 7174K 7174 results in increased expression of GDF15 mRNA24086573
C037068latrunculin Blatrunculin B results in increased expression of GDF15 mRNA23996089
C037068latrunculin Blatrunculin B results in increased expression of GDF15 protein23996089
C037068latrunculin B[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]23996089
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA12634122
C045463leflunomideleflunomide results in increased expression of GDF15 mRNA28988120
C533894LG 100815LG 100815 results in increased expression of GDF15 mRNA16951191
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GDF15 mRNA27339419
D008154LucanthoneLucanthone results in increased expression of GDF15 mRNA21148553
D008345ManganeseManganese results in increased expression of GDF15 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of GDF15 mRNA17175027
C042720mercuric bromidemercuric bromide results in increased expression of GDF15 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GDF15 mRNA16507785
D019216Metals, Heavy"Metals, Heavy results in decreased expression of GDF15 mRNA"12773770
D008687MetforminMetformin results in increased expression of GDF15 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of GDF15 mRNA25290377
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of GDF15 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of GDF15 mRNA19564919
D008701MethapyrileneMethapyrilene results in increased expression of GDF15 mRNA15890375
C002950methylformamidemethylformamide analog results in increased expression of GDF15 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of GDF15 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GDF15 mRNA26272509|2800136
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GDF15 mRNA22129749
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GDF15 mRNA23649840|2421176
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of GDF15 mRNA12634122|1277377
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GDF15 mRNA24810058
D015741MetriboloneMetribolone results in increased expression of GDF15 mRNA17010196
D016685MitomycinMitomycin results in increased expression of GDF15 mRNA24211769
D008942MitoxantroneMitoxantrone results in increased expression of GDF15 mRNA26537877|2894005
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter18448484
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of GDF15 mRNA22108045
D009151Mustard GasMustard Gas results in increased expression of GDF15 mRNA25102026
D009151Mustard GasMustard Gas affects the expression of GDF15 mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GDF15 mRNA"29244179
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of GDF15 protein15180942
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GDF15 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GDF15 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GDF15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GDF15 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GDF15 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of GDF15 mRNA18978301
C031721naphthalenenaphthalene analog results in increased expression of GDF15 mRNA24976557
D009285NaphthoquinonesNaphthoquinones results in increased expression of GDF15 mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GDF15 mRNA19812364
C101954N-caproylsphingosineN-caproylsphingosine results in increased expression of GDF15 mRNA15459768
C101954N-caproylsphingosineN-caproylsphingosine results in increased expression of GDF15 protein15459768
C115174netoglitazoneKLF4 mRNA affects the reaction [netoglitazone results in increased expression of GDF15 protein]22750490
C115174netoglitazonenetoglitazone results in increased expression of GDF15 mRNA22750490
C115174netoglitazonenetoglitazone results in increased expression of GDF15 protein22750490
C022838nickel chloridenickel chloride results in increased expression of GDF15 mRNA17312168
C029938nickel sulfatenickel sulfate results in increased expression of GDF15 mRNA18651567
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GDF15 mRNA19716841
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GDF15 mRNA27935865
C570896NSC305787NSC305787 results in increased expression of GDF15 mRNA27137931
C570897NSC668394NSC668394 results in increased expression of GDF15 mRNA27137931
C482205nutlin 3nutlin 3 results in increased expression of GDF15 mRNA16439677
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of GDF15 mRNA"16951191
D015282Octreotide[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA17959037
D008939MitotaneMitotane results in increased expression of GDF15 mRNA22966885
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GDF15 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GDF15 mRNA25729387
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of GDF15 mRNA]22535156
D010100OxygenOxygen deficiency results in decreased expression of GDF15 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of GDF15 mRNA25596134
D010100OxygenOxygen results in increased expression of GDF15 mRNA28734801
D010100OxygenOxygen results in increased expression of GDF15 protein28734801
D010100OxygenOxygen results in increased expression of GDF1528734801
D010269ParaquatParaquat results in increased expression of GDF15 mRNA20883675
D052638Particulate MatterParticulate Matter results in increased expression of GDF15 mRNA22178795
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GDF15 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GDF15 mRNA26705709
C046012pentanalpentanal results in increased expression of GDF15 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GDF15 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GDF15 protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GDF15 mRNA17097637
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GDF15 mRNA]19482888
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of GDF15 mRNA]19850644
D010634PhenobarbitalPhenobarbital results in increased expression of GDF15 mRNA19482888|1985064
D010656PhenylephrinePhenylephrine affects the expression of GDF15 mRNA19505289
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GDF15 mRNA26272509
D010696PhloroglucinolPhloroglucinol analog results in increased expression of GDF15 protein23178381
D010705PhosgenePhosgene affects the expression of GDF15 mRNA16300373
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]20064835
C049032pinosylvinpinosylvin results in increased expression of GDF15 mRNA23333577
C049032pinosylvinpinosylvin results in increased expression of GDF15 protein23333577
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GDF15 mRNA27935865
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GDF15 mRNA15890375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GDF15 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of GDF15 mRNA18445702|1985064
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of GDF15 mRNA]19850644
C006253pirinixic acidpirinixic acid results in increased expression of GDF15 mRNA15890375
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of GDF15 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of GDF15 mRNA21858171
D010938Plant OilsPlant Oils results in increased expression of GDF15 mRNA23370395
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of GDF15 mRNA24583197
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of GDF15 protein24583197
D011192Potassium DichromatePotassium Dichromate results in increased expression of GDF15 mRNA18332044
D011335ProadifenProadifen results in increased expression of GDF1522683934
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of GDF15 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of GDF15 mRNA18037150
D011374ProgesteroneProgesterone results in decreased expression of GDF15 mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of GDF15 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of GDF15 mRNA26079696
C107773pterostilbenepterostilbene results in increased expression of GDF15 mRNA22450950
C432165pyrazolanthronepyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein]24440808
C010423pyrithione zincpyrithione zinc results in increased expression of GDF15 mRNA21424779
D011794QuercetinQuercetin results in decreased expression of GDF15 mRNA15309432
D011794QuercetinQuercetin results in increased expression of GDF15 mRNA21632981
C059514resveratrolDactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA]17257620
C059514resveratrol[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF1515670751
C059514resveratrolresveratrol metabolite results in increased expression of GDF15 protein11895857
C059514resveratrolresveratrol promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]11895857|1189585
C059514resveratrolresveratrol results in increased expression of GDF15 mRNA11895857|1725762
C059514resveratrolresveratrol results in increased expression of GDF15 protein11895857
C059514resveratrol[resveratrol results in increased expression of TP53] promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15]11895857
C059514resveratrol[resveratrol results in increased expression of TP53 protein] which results in increased expression of GDF15 protein11895857
C059514resveratrolresveratrol results in increased expression of GDF1524440808
D015474IsotretinoinIsotretinoin results in increased expression of GDF15 mRNA15982314
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]18058799
C089730rosiglitazonerosiglitazone results in increased expression of GDF15 mRNA16982809|2557248
C089730rosiglitazone[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of GDF15 mRNA20512989
C089730rosiglitazone[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of GDF15 protein20512989
D012402RotenoneRotenone results in increased expression of GDF15 mRNA27900601
C085746rottlerin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]22410117
C085746rottlerinGDF15 affects the susceptibility to rottlerin22410117
C085746rottlerinrottlerin results in increased expression of GDF15 mRNA22410117
C085746rottlerinrottlerin results in increased expression of GDF15 protein22410117
C085746rottlerinSB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]22410117
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GDF15 mRNA"16678137
C093642SB 203580[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]23996089
C093642SB 203580[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]23996089
C093642SB 203580[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]23996089
C093642SB 203580SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]22410117
C093642SB 203580SB 203580 inhibits the reaction [silybin results in increased expression of GDF15 protein]24440808
C417521SB 216763SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]17257745
C115461SC 560SC 560 results in increased expression of GDF15 mRNA14633654
C115461SC 560SC 560 results in increased expression of GDF15 protein14633654|1550971
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of GDF15 mRNA19564919
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of GDF15 mRNA"24160326
C040115shogaolshogaol results in increased expression of GDF15 mRNA25148906
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GDF15 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of GDF15 mRNA19073995|2322117
D012834SilverSilver results in increased expression of GDF15 mRNA27131904
C440975silybinEGR1 mutant form inhibits the reaction [silybin results in increased expression of GDF15 protein]24440808
C440975silybinGDF15 mutant form inhibits the reaction [silybin results in increased cleavage of PARP1 protein]24440808
C440975silybinpyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein]24440808
C440975silybinSB 203580 inhibits the reaction [silybin results in increased expression of GDF15 protein]24440808
C440975silybinsilybin results in increased expression of GDF15 mRNA24440808
C440975silybinsilybin results in increased expression of GDF15 protein24440808
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter18448484
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of GDF15 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of GDF15 mRNA23876855|2587980
C017947sodium arsenitesodium arsenite results in increased expression of GDF15 protein25879800
C017947sodium arsenitesodium arsenite results in increased expression of GDF15 mRNA16014739
D0150862,6-Dichloroindophenol"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA"21034357
D018038Sodium SeleniteSodium Selenite results in increased expression of GDF15 mRNA24383545
D053260SootSoot results in increased expression of GDF15 mRNA26551751
D013467SulindacSulindac results in increased expression of GDF15 mRNA11906190
D013467SulindacSulindac results in increased expression of GDF15 protein15180942
D013467SulindacSulindac results in increased expression of GDF15 protein11984525
C025462sulindac sulfideEGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]15509713
C025462sulindac sulfidesulindac sulfide results in increased expression of GDF15 mRNA15509713
C025462sulindac sulfidesulindac sulfide results in increased expression of GDF15 protein11895857|1192547
C025462sulindac sulfidesulindac sulfide results in increased expression of GDF15 mRNA18076062
D013629TamoxifenGDF15 protein results in decreased susceptibility to Tamoxifen22615612
D013629TamoxifenTamoxifen affects the expression of GDF15 mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of GDF15 mRNA25123088
C003377taxifolintaxifolin results in increased expression of GDF15 mRNA17541156
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA26159488
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA19619570
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GDF15 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GDF15 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GDF15 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GDF15 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GDF15 mRNA21215274
D013755Tetradecanoylphorbol Acetate[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]23996089
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GDF15 protein23996089
D019284ThapsigarginThapsigargin results in increased expression of GDF15 mRNA22378314
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein18951874
D013853ThioacetamideThioacetamide results in increased expression of GDF15 mRNA23411599
D013883ThiostreptonThiostrepton results in increased expression of GDF15 mRNA22321511
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of GDF15 mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of GDF15 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GDF15 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GDF15 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GDF15 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GDF15 mRNA25729387
D014212TretinoinTretinoin metabolite results in increased expression of GDF15 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of GDF15 mRNA17045167
D014212TretinoinTretinoin results in increased expression of GDF15 mRNA15982314|2383079
D014241TrichloroethyleneTrichloroethylene results in increased expression of GDF15 mRNA25549359
C012589trichostatin ACycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 mRNA]18801729
C012589trichostatin ACycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 protein]18801729
C012589trichostatin Adecitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 mRNA]18801729|1880172
C012589trichostatin Adecitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 protein]18801729|1880172
C012589trichostatin AEGR1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]18801729
C012589trichostatin ASP1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]18801729
C012589trichostatin Atrichostatin A results in increased expression of GDF15 mRNA24935251
C012589trichostatin A[trichostatin A results in increased expression of GDF15 protein] which results in increased cleavage of PARP1 protein18801729
C012589trichostatin A[trichostatin A results in increased stability of GDF15 mRNA] which results in increased expression of GDF15 protein18801729|1880172
C050414tripterinetripterine results in increased expression of GDF15 mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GDF15 mRNA"26179874
C057693troglitazone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of GDF15 protein]14662774
C057693troglitazoneCycloheximide inhibits the reaction [troglitazone results in increased expression of GDF15 mRNA]14662774
C057693troglitazone[EGR1 protein binds to GDF15 promoter] affects the reaction [troglitazone results in increased expression of GDF15]14662774
C057693troglitazonetroglitazone results in increased expression of GDF15 mRNA14662774|1914023
C057693troglitazonetroglitazone results in increased expression of GDF15 protein14662774|2146157
C002802tungsten carbide[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA20105288
D017973Tungsten CompoundsTungsten Compounds results in increased expression of GDF15 mRNA28666766
D014415TunicamycinTunicamycin results in increased expression of GDF15 mRNA22378314
D014520UrethaneUrethane results in increased expression of GDF15 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GDF15 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GDF15 mRNA23179753|2493525
C066075vanadium pentoxidevanadium pentoxide results in increased expression of GDF15 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GDF15 gene25560391
D014750VincristineVincristine results in increased expression of GDF15 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of GDF15 mRNA26682919
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of GDF15 mRNA23825117
D014800VitalliumVitallium analog results in increased expression of GDF15 mRNA23825117
D000225AdenineAdenine results in decreased expression of GDF15 mRNA24211769
D024483Vitamin K 3Vitamin K 3 affects the expression of GDF15 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased expression of GDF15 mRNA12414654
C009687wortmanninwortmannin results in increased expression of GDF15 protein23178381
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GDF15 mRNA18593933
D015032ZincZinc deficiency results in increased expression of GDF15 mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of GDF15 mRNA]19111725
C088658zoledronic acidzoledronic acid results in decreased expression of GDF15 mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005515protein binding-IPI19060904  25893289  28846098  28846099  28953886  
GO:0008083growth factor activity-IEA-  
GO:0042803protein homodimerization activity-IDA29046435  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA28953886  
GO:0002023reduction of food intake in response to dietary excess-IDA28846097  28846098  28846099  28953886  29046435  
GO:0007165signal transduction-TAS9326641  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS9348093  
GO:0007267cell-cell signaling-TAS9326641  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0035860glial cell-derived neurotrophic factor receptor signaling pathway-IDA28953886  
GO:0040015negative regulation of multicellular organism growth-ISS-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IMP28846099  
GO:0048468cell development-IBA21873635  
GO:0051897positive regulation of protein kinase B signaling-IDA28846097  
GO:0051897positive regulation of protein kinase B signaling-IMP28846099  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060395SMAD protein signal transduction-IDA25893289  
GO:0060400negative regulation of growth hormone receptor signaling pathway-ISS-  
GO:1901741positive regulation of myoblast fusion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA28572090  29046435  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA25893289  
GO:0005634nucleus-IDA25893289  
GO:0005737cytoplasm-IDA25893289  
GO:0005794Golgi apparatus-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26090487GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis. (2015)Amaya-Amaya JJ Immunol Res
25721048Genetic variants in TNFalpha, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. (2016)Yucesoy BJ Immunotoxicol
22997280Clinical and genetic correlates of growth differentiation factor 15 in the community. (2012 Nov)Ho JEClin Chem
18657084Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors. (2008 Oct)Mast AETransfusion
19505289The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension. (2009 Oct 19)Wang XClin Sci (Lond)
28798540Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors. (2017)Hsu LAMediators Inflamm
28298399Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD. (2017 Mar)Husebo GREur Respir J
28898507Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)Koo BKLiver Int