Gene info: ID 9518

Gene: GDF15

GENE ID: 9518

Synonyms: GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB

Description: growth differentiation factor 15

Gene type: protein-coding

Location: 19p13.11

dbXrefs: Ensembl:ENSG00000130513 MIM:605312 Vega:OTTHUMG00000183360 UniprotKB:Q99988

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.697e-1 (AD) 4.652e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CCRL2	0.725
ICAM1	0.716
APOL3	0.698
TRIM5	0.698
PARP12	0.697
SP100	0.697
TNFAIP3	0.692
STX11	0.692
VCAM1	0.69
HELZ2	0.688

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASIC2	-0.447
MYADML2	-0.438
CHRNB2	-0.434
TMEM179	-0.434
SLC7A4	-0.427
HRH3	-0.418
OMG	-0.417
DNAJC28	-0.417
ZNF835	-0.417
GABRA5	-0.417

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of GDF15 mRNA"	26377693
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of GDF15 mRNA"	26377693
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of GDF15 mRNA	25596134
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GDF15 mRNA"	19850644\|2135444
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GDF15 mRNA]"	19850644
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]	22410117
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of GDF15 protein]	14662774
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GDF15 mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GDF15 mRNA"	21346803
C457499	2-chloro-5-nitrobenzanilide	[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]	14662774
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of GDF15 mRNA	14600272\|1589037
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of GDF15 mRNA"	15670751
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of GDF15 mRNA"	20638727
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GDF15 mRNA"	19692669
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of GDF15 mRNA"	24172598
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of GDF15 mRNA	18544908
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]	21097678
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]	21097678
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of GDF15 mRNA"	21346803
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GDF15 mRNA	14600272\|1589037
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of GDF15 mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of GDF15 mRNA"	28073004
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of GDF15 mRNA"	26238291
C037112	9-deoxy-delta-9-prostaglandin D2	[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]	14662774
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 mRNA	14662774
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein	14662774
C056498	aceclofenac	aceclofenac results in increased expression of GDF15 protein	15555568
C056498	aceclofenac	aceclofenac results in increased expression of GDF15 mRNA	18076062
D000082	Acetaminophen	Acetaminophen results in increased expression of GDF15 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of GDF15 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of GDF15 mRNA	18544908\|2605643
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA]	17585979
D020106	Acrylamide	Acrylamide results in increased expression of GDF15 mRNA	28959563
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of GDF15 mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GDF15 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GDF15 mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GDF15 mRNA	14600272\|1589037
D000393	Air Pollutants	Air Pollutants analog results in increased expression of GDF15 mRNA	21757418
D000447	Aldehydes	Aldehydes results in increased expression of GDF15 mRNA	25014914
C103303	alitretinoin	alitretinoin results in increased expression of GDF15 mRNA	15982314
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of GDF15 mRNA	16523695
C068073	Am 580	Am 580 results in increased expression of GDF15 mRNA	16982809
D000638	Amiodarone	Amiodarone results in increased expression of GDF15 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GDF15 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of GDF15 mRNA"	22863853
D001115	Arecoline	Arecoline results in increased expression of GDF15 mRNA	17682004
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GDF15 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GDF15 mRNA	23912714
D001149	Arsenates	Arsenates results in decreased expression of GDF15 mRNA	12773770
D001151	Arsenic	Arsenic results in decreased expression of GDF15 mRNA	12773770
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GDF15 mRNA	19036111\|2525818
D017636	Asbestos, Amphibole	"Asbestos, Amphibole affects the expression of GDF15 protein"	20855422
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of GDF15 mRNA"	25757056
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of GDF15 mRNA"	18687144
D001241	Aspirin	Aspirin results in increased expression of GDF15 mRNA	14976132
D001241	Aspirin	Aspirin results in increased expression of GDF15 protein	15180942
D001280	Atrazine	Atrazine results in increased expression of GDF15 mRNA	22378314
C017037	aurin	aurin results in increased expression of GDF15 mRNA	25477506
D001379	Azathioprine	Azathioprine results in increased expression of GDF15 mRNA	22623647
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of GDF15 mRNA	26377693
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GDF15 mRNA	19737606
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of GDF15 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GDF15 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GDF15 mRNA	21569818\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GDF15 mRNA"	19150397\|2038263
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA	25566086
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA]	25566086
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of GDF15 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of GDF15 mRNA	19167446
D004958	Estradiol	Estradiol results in increased expression of GDF15 mRNA	19619570\|2010694
D004958	Estradiol	Estradiol results in increased expression of GDF15 mRNA	25210133
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid affects the expression of GDF15 mRNA	18192240
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA	28628672
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of GDF15 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of GDF15 mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of GDF15 mRNA	25047013\|2768578
C006780	bisphenol A	bisphenol A results in increased secretion of GDF15 protein	27745655
C006780	bisphenol A	bisphenol A results in increased expression of GDF15 mRNA	25181051
D000069286	Bortezomib	[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of GDF15 mRNA	25522274
D000069286	Bortezomib	Bortezomib results in increased expression of GDF15 mRNA	20830808
C016274	bromoacetate	bromoacetate results in increased expression of GDF15 mRNA	19753638
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GDF15 mRNA	22079614
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA	24910943
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GDF15 mRNA	12414654
C018475	butyraldehyde	butyraldehyde results in increased expression of GDF15 mRNA	26079696
C584509	C646 compound	C646 compound affects the expression of GDF15 mRNA	26191083
C584509	C646 compound	C646 compound results in increased expression of GDF15 mRNA	26921506
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GDF15 mRNA	25596134
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of GDF15 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GDF15 mRNA	19010381
D002185	Cannabidiol	Cannabidiol results in increased expression of GDF15 mRNA	21542829
D002211	Capsaicin	ATF3 mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283
D002211	Capsaicin	Capsaicin results in increased expression of GDF15 mRNA	20110283
D002211	Capsaicin	Capsaicin results in increased phosphorylation of GDF15 protein	20110283
D002211	Capsaicin	CEBPB mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283
D002211	Capsaicin	[CEBPB protein binds to GDF15 promoter] promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283\|2011028
D002211	Capsaicin	CEBPB protein promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283
D002211	Capsaicin	GSK3B mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283
D002220	Carbamazepine	Carbamazepine affects the expression of GDF15 mRNA	25979313
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of GDF15 mRNA	16039398
D002392	Catechin	Catechin results in increased expression of GDF15	24440808
D000068579	Celecoxib	[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA	17959037
D000068579	Celecoxib	Celecoxib results in increased expression of GDF15	17257745
D000068579	Celecoxib	Celecoxib results in increased expression of GDF15 mRNA	17959037\|1808984
D000068579	Celecoxib	GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]	17257745
D000068579	Celecoxib	PTGS2 protein affects the reaction [Celecoxib results in increased expression of GDF15 mRNA]	18089846
D000068579	Celecoxib	SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]	17257745
D002509	Cephaloridine	Cephaloridine results in decreased expression of GDF15 mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of GDF15 mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of GDF15 mRNA	26272509
C100187	chloropicrin	chloropicrin results in increased expression of GDF15 mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of GDF15 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine results in increased expression of GDF15 mRNA	25596134
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA	12634122
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of GDF15 mRNA	28472532
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA	12634122
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA	27858113
C031180	chrysene	chrysene results in decreased expression of GDF15 mRNA	26377693
C059262	cidofovir	cidofovir results in increased expression of GDF15 mRNA	25596134
D002922	Ciguatoxins	Ciguatoxins affects the expression of GDF15 mRNA	18353800
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of GDF15 mRNA	25596134
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GDF15 mRNA]	17585979
D003033	Coal Tar	Coal Tar results in increased expression of GDF15 mRNA	27858113
D003035	Cobalt	[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GDF15 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GDF15 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GDF15 mRNA	24386269
D003078	Colchicine	Colchicine results in decreased expression of GDF15 mRNA	24211769
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of GDF15 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GDF15 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GDF15 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of GDF15 mRNA	19167446
C402665	CP 31398	CP 31398 results in increased expression of GDF15 mRNA	15155752
C024015	cryptolepine	cryptolepine results in increased expression of GDF15 mRNA	16120219
C030973	cupric oxide	cupric oxide results in increased expression of GDF15 mRNA	22077320
D003513	Cycloheximide	Cycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 mRNA]	18801729
D003513	Cycloheximide	Cycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 protein]	18801729
D003513	Cycloheximide	Cycloheximide inhibits the reaction [troglitazone results in increased expression of GDF15 mRNA]	14662774
D016572	Cyclosporine	Cyclosporine results in increased expression of GDF15 mRNA	19159671\|2010694
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of GDF15 mRNA	23726867\|2492166
D003609	Dactinomycin	Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA]	17257620
C515055	darinaparsin	darinaparsin results in decreased expression of GDF15 mRNA	22535156
C515055	darinaparsin	Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of GDF15 mRNA]	22535156
D003630	Daunorubicin	Daunorubicin results in increased expression of GDF15 mRNA	26537877\|2894005
C014347	decitabine	decitabine affects the expression of GDF15 mRNA	17145863\|2330084
C014347	decitabine	decitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 mRNA]	18801729\|1880172
C014347	decitabine	decitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 protein]	18801729\|1880172
C014347	decitabine	decitabine results in increased expression of GDF15 mRNA	27915011
D013759	Dronabinol	Dronabinol results in decreased expression of GDF15 mRNA	16039398
D013759	Dronabinol	Dronabinol results in increased expression of GDF15 mRNA	16039398
D013759	Dronabinol	Dronabinol results in increased expression of GDF15 mRNA	21542829
D003703	Demecolcine	Demecolcine results in increased expression of GDF15 mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in decreased expression of GDF15 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in decreased expression of GDF15 mRNA	22733784
C028009	diallyl disulfide	diallyl disulfide results in increased expression of GDF15 protein	11925476
C028009	diallyl disulfide	TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]	11925476
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GDF15 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GDF15 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of GDF15 mRNA	28962523
D002945	Cisplatin	Cisplatin affects the expression of GDF15 mRNA	23300844
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of GDF15 mRNA]	21858171
D002945	Cisplatin	Cisplatin results in increased expression of GDF15 mRNA	21532991\|2421176
D002945	Cisplatin	Folic Acid affects the reaction [Cisplatin affects the expression of GDF15 mRNA]	16898872
D002945	Cisplatin	Cisplatin results in increased expression of GDF15 mRNA	21151649
D004008	Diclofenac	Diclofenac results in increased expression of GDF15 protein	15555568
D004008	Diclofenac	Diclofenac results in increased expression of GDF15 mRNA	18076062
C000944	dicrotophos	dicrotophos results in increased expression of GDF15 mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of GDF15 mRNA	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GDF15 mRNA	21527772
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GDF15 mRNA	19100860\|2160768
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GDF15 mRNA	15890375
D002117	Calcitriol	Calcitriol results in increased expression of GDF15 mRNA	15386353\|1652369
D002117	Calcitriol	Calcitriol results in increased expression of GDF15 protein	15386353
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in increased expression of GDF15 mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of GDF15 mRNA	14600272\|1589037
D004237	Diuron	Diuron metabolite results in increased expression of GDF15 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of GDF15 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in decreased expression of GDF15 mRNA	16705698
D004317	Doxorubicin	Doxorubicin results in increased expression of GDF15 mRNA	15205334\|2552947
D004317	Doxorubicin	GDF15 protein results in decreased susceptibility to Doxorubicin	22615612
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GDF15 mRNA"	23811387
C479799	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of GDF15 mRNA	15528975
C479799	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in increased expression of GDF15 mRNA	15528975
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA	26159488
C118739	entinostat	entinostat results in increased expression of GDF15 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
D000431	Ethanol	Ethanol results in increased expression of GDF15 mRNA	28986285
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GDF15 mRNA	23649840\|2421176
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of GDF15 mRNA	19100860
D005047	Etoposide	Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]	11895857\|1189585
D005047	Etoposide	Etoposide results in increased expression of GDF15 mRNA	16120219\|2421176
D005047	Etoposide	Etoposide results in increased expression of GDF15 protein	11895857
D005047	Etoposide	[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein	11895857
C540355	fenamidone	fenamidone results in increased expression of GDF15 mRNA	27029645
D011345	Fenofibrate	Fenofibrate results in increased expression of GDF15 mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in increased expression of GDF15 mRNA	25596134
C024352	fludarabine	fludarabine results in increased expression of GDF15 mRNA	16439677
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of GDF15 mRNA	21607683
D005472	Fluorouracil	Fluorouracil results in increased expression of GDF15 mRNA	15205334
D005472	Fluorouracil	Fluorouracil results in increased expression of GDF15 protein	14665630
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in increased expression of GDF15 mRNA]	15016801
D005480	Flurbiprofen	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]	21097678
D005480	Flurbiprofen	Flurbiprofen results in increased expression of GDF15 protein	21097678
D005480	Flurbiprofen	MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]	21097678
D005480	Flurbiprofen	NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]	21097678
D005485	Flutamide	Flutamide results in increased expression of GDF15 mRNA	24793618
D005492	Folic Acid	Folic Acid affects the reaction [Cisplatin affects the expression of GDF15 mRNA]	16898872
D005557	Formaldehyde	Formaldehyde results in decreased expression of GDF15 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of GDF15 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of GDF15 mRNA	19167457
C039281	furan	[Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA	24910943
C039281	furan	furan results in increased expression of GDF15 mRNA	24183702\|2491094
C039281	furan	furan results in decreased expression of GDF15 mRNA	26194646
C039281	furan	furan results in increased methylation of GDF15 gene	22079235
C106014	gedunin	gedunin results in increased expression of GDF15 mRNA	17010675
D019833	Genistein	Genistein results in decreased expression of GDF15 mRNA	20884965
D019833	Genistein	Genistein results in increased expression of GDF15 mRNA	22228119\|2686566
D019833	Genistein	Genistein results in increased expression of GDF15 mRNA	16169203
D019833	Genistein	Genistein results in increased expression of GDF15	24440808
D005839	Gentamicins	Gentamicins results in decreased expression of GDF15 mRNA	22061828
C007845	gingerol	gingerol results in increased expression of GDF15 mRNA	18058799
C007845	gingerol	gingerol results in increased expression of GDF15 protein	18058799
C007845	gingerol	GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]	18058799
C007845	gingerol	PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]	18058799
C007845	gingerol	Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]	18058799
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in increased expression of GDF15 mRNA	16206274
D019307	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]	23996089
D019307	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]	23996089
D019307	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]	23996089
D017313	Fenretinide	Fenretinide results in increased expression of GDF15 mRNA	15958647\|1667109
D017313	Fenretinide	Fenretinide results in increased expression of GDF15 protein	15958647
D017313	Fenretinide	Fenretinide results in increased expression of GDF15 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GDF15 mRNA	20044591
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GDF15	18687144
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GDF15 mRNA	12414654\|1545976
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GDF15 protein	15459768
C031927	hydroquinone	hydroquinone results in increased expression of GDF15 mRNA	23416264
D006918	Hydroxyurea	Hydroxyurea results in increased expression of GDF15 mRNA	24211769
D007052	Ibuprofen	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]	21097678
D007052	Ibuprofen	Ibuprofen results in increased expression of GDF15 mRNA	25596134
D007052	Ibuprofen	Ibuprofen results in increased expression of GDF15 protein	15555568\|2109767
D007052	Ibuprofen	MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]	21097678
D007052	Ibuprofen	NGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]	21097678
C492448	ICG 001	ICG 001 results in increased expression of GDF15 mRNA	26191083
D007069	Ifosfamide	Ifosfamide results in increased expression of GDF15 mRNA	25596134
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF15	15670751
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GDF15	15670751
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GDF15	24440808
D007213	Indomethacin	GDF15 protein results in decreased susceptibility to Indomethacin	22615612
D007213	Indomethacin	Indomethacin results in increased expression of GDF15 mRNA	15509713\|1698473
D007213	Indomethacin	Indomethacin results in increased expression of GDF15 protein	15180942\|1550971
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA	28628672
D007213	Indomethacin	Indomethacin results in increased expression of GDF15 mRNA	18076062
C051890	irinotecan	irinotecan metabolite results in increased expression of GDF15 mRNA	15956246
C051890	irinotecan	irinotecan results in increased expression of GDF15 mRNA	15956246
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GDF15 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GDF15 mRNA	28628672
C057531	jasplakinolide	jasplakinolide results in increased expression of GDF15 mRNA	23996089
C057531	jasplakinolide	jasplakinolide results in increased expression of GDF15 protein	23996089
C057531	jasplakinolide	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]	23996089
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of GDF15 mRNA	24796395
C410337	K 7174	K 7174 results in increased expression of GDF15 mRNA	24086573
C410337	K 7174	K 7174 results in increased expression of GDF15 mRNA	24086573
C037068	latrunculin B	latrunculin B results in increased expression of GDF15 mRNA	23996089
C037068	latrunculin B	latrunculin B results in increased expression of GDF15 protein	23996089
C037068	latrunculin B	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]	23996089
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA	12634122
C045463	leflunomide	leflunomide results in increased expression of GDF15 mRNA	28988120
C533894	LG 100815	LG 100815 results in increased expression of GDF15 mRNA	16951191
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GDF15 mRNA	27339419
D008154	Lucanthone	Lucanthone results in increased expression of GDF15 mRNA	21148553
D008345	Manganese	Manganese results in increased expression of GDF15 mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of GDF15 mRNA	17175027
C042720	mercuric bromide	mercuric bromide results in increased expression of GDF15 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDF15 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of GDF15 mRNA	16507785
D019216	Metals, Heavy	"Metals, Heavy results in decreased expression of GDF15 mRNA"	12773770
D008687	Metformin	Metformin results in increased expression of GDF15 mRNA	25596134
D008694	Methamphetamine	Methamphetamine results in increased expression of GDF15 mRNA	25290377
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of GDF15 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of GDF15 mRNA	19564919
D008701	Methapyrilene	Methapyrilene results in increased expression of GDF15 mRNA	15890375
C002950	methylformamide	methylformamide analog results in increased expression of GDF15 mRNA	17040096
C002950	methylformamide	methylformamide results in increased expression of GDF15 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GDF15 mRNA	26272509\|2800136
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of GDF15 mRNA	22129749
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GDF15 mRNA	23649840\|2421176
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of GDF15 mRNA	12634122\|1277377
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of GDF15 mRNA	24810058
D015741	Metribolone	Metribolone results in increased expression of GDF15 mRNA	17010196
D016685	Mitomycin	Mitomycin results in increased expression of GDF15 mRNA	24211769
D008942	Mitoxantrone	Mitoxantrone results in increased expression of GDF15 mRNA	26537877\|2894005
C406082	monomethylarsonous acid	[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter	18448484
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of GDF15 mRNA	22108045
D009151	Mustard Gas	Mustard Gas results in increased expression of GDF15 mRNA	25102026
D009151	Mustard Gas	Mustard Gas affects the expression of GDF15 mRNA	15651846
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GDF15 mRNA"	29244179
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of GDF15 protein	15180942
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GDF15 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GDF15 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GDF15 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GDF15 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GDF15 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of GDF15 mRNA	18978301
C031721	naphthalene	naphthalene analog results in increased expression of GDF15 mRNA	24976557
D009285	Naphthoquinones	Naphthoquinones results in increased expression of GDF15 mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of GDF15 mRNA	19812364
C101954	N-caproylsphingosine	N-caproylsphingosine results in increased expression of GDF15 mRNA	15459768
C101954	N-caproylsphingosine	N-caproylsphingosine results in increased expression of GDF15 protein	15459768
C115174	netoglitazone	KLF4 mRNA affects the reaction [netoglitazone results in increased expression of GDF15 protein]	22750490
C115174	netoglitazone	netoglitazone results in increased expression of GDF15 mRNA	22750490
C115174	netoglitazone	netoglitazone results in increased expression of GDF15 protein	22750490
C022838	nickel chloride	nickel chloride results in increased expression of GDF15 mRNA	17312168
C029938	nickel sulfate	nickel sulfate results in increased expression of GDF15 mRNA	18651567
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of GDF15 mRNA	19716841
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GDF15 mRNA	27935865
C570896	NSC305787	NSC305787 results in increased expression of GDF15 mRNA	27137931
C570897	NSC668394	NSC668394 results in increased expression of GDF15 mRNA	27137931
C482205	nutlin 3	nutlin 3 results in increased expression of GDF15 mRNA	16439677
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of GDF15 mRNA"	16951191
D015282	Octreotide	[Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA	17959037
D008939	Mitotane	Mitotane results in increased expression of GDF15 mRNA	22966885
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of GDF15 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of GDF15 mRNA	25729387
D010100	Oxygen	Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of GDF15 mRNA]	22535156
D010100	Oxygen	Oxygen deficiency results in decreased expression of GDF15 mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in increased expression of GDF15 mRNA	25596134
D010100	Oxygen	Oxygen results in increased expression of GDF15 mRNA	28734801
D010100	Oxygen	Oxygen results in increased expression of GDF15 protein	28734801
D010100	Oxygen	Oxygen results in increased expression of GDF15	28734801
D010269	Paraquat	Paraquat results in increased expression of GDF15 mRNA	20883675
D052638	Particulate Matter	Particulate Matter results in increased expression of GDF15 mRNA	22178795
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of GDF15 mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of GDF15 mRNA	26705709
C046012	pentanal	pentanal results in increased expression of GDF15 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GDF15 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GDF15 protein	26879310
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of GDF15 mRNA	17097637
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GDF15 mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of GDF15 mRNA]	19850644
D010634	Phenobarbital	Phenobarbital results in increased expression of GDF15 mRNA	19482888\|1985064
D010656	Phenylephrine	Phenylephrine affects the expression of GDF15 mRNA	19505289
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of GDF15 mRNA	26272509
D010696	Phloroglucinol	Phloroglucinol analog results in increased expression of GDF15 protein	23178381
D010705	Phosgene	Phosgene affects the expression of GDF15 mRNA	16300373
C121565	pifithrin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]	20064835
C049032	pinosylvin	pinosylvin results in increased expression of GDF15 mRNA	23333577
C049032	pinosylvin	pinosylvin results in increased expression of GDF15 protein	23333577
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GDF15 mRNA	27935865
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GDF15 mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GDF15 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of GDF15 mRNA	18445702\|1985064
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GDF15 mRNA]	19850644
C006253	pirinixic acid	pirinixic acid results in increased expression of GDF15 mRNA	15890375
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of GDF15 mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of GDF15 mRNA	21858171
D010938	Plant Oils	Plant Oils results in increased expression of GDF15 mRNA	23370395
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of GDF15 mRNA	24583197
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of GDF15 protein	24583197
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of GDF15 mRNA	18332044
D011335	Proadifen	Proadifen results in increased expression of GDF15	22683934
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of GDF15 mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of GDF15 mRNA	18037150
D011374	Progesterone	Progesterone results in decreased expression of GDF15 mRNA	22238285
D011374	Progesterone	Progesterone results in increased expression of GDF15 mRNA	20726854
C005556	propionaldehyde	propionaldehyde results in increased expression of GDF15 mRNA	26079696
C107773	pterostilbene	pterostilbene results in increased expression of GDF15 mRNA	22450950
C432165	pyrazolanthrone	pyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein]	24440808
C010423	pyrithione zinc	pyrithione zinc results in increased expression of GDF15 mRNA	21424779
D011794	Quercetin	Quercetin results in decreased expression of GDF15 mRNA	15309432
D011794	Quercetin	Quercetin results in increased expression of GDF15 mRNA	21632981
C059514	resveratrol	Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA]	17257620
C059514	resveratrol	[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF15	15670751
C059514	resveratrol	resveratrol metabolite results in increased expression of GDF15 protein	11895857
C059514	resveratrol	resveratrol promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]	11895857\|1189585
C059514	resveratrol	resveratrol results in increased expression of GDF15 mRNA	11895857\|1725762
C059514	resveratrol	resveratrol results in increased expression of GDF15 protein	11895857
C059514	resveratrol	[resveratrol results in increased expression of TP53] promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15]	11895857
C059514	resveratrol	[resveratrol results in increased expression of TP53 protein] which results in increased expression of GDF15 protein	11895857
C059514	resveratrol	resveratrol results in increased expression of GDF15	24440808
D015474	Isotretinoin	Isotretinoin results in increased expression of GDF15 mRNA	15982314
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]	18058799
C089730	rosiglitazone	rosiglitazone results in increased expression of GDF15 mRNA	16982809\|2557248
C089730	rosiglitazone	[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of GDF15 mRNA	20512989
C089730	rosiglitazone	[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of GDF15 protein	20512989
D012402	Rotenone	Rotenone results in increased expression of GDF15 mRNA	27900601
C085746	rottlerin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]	22410117
C085746	rottlerin	GDF15 affects the susceptibility to rottlerin	22410117
C085746	rottlerin	rottlerin results in increased expression of GDF15 mRNA	22410117
C085746	rottlerin	rottlerin results in increased expression of GDF15 protein	22410117
C085746	rottlerin	SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]	22410117
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GDF15 mRNA"	16678137
C093642	SB 203580	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]	23996089
C093642	SB 203580	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]	23996089
C093642	SB 203580	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]	23996089
C093642	SB 203580	SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]	22410117
C093642	SB 203580	SB 203580 inhibits the reaction [silybin results in increased expression of GDF15 protein]	24440808
C417521	SB 216763	SB 216763 inhibits the reaction [Celecoxib results in increased expression of GDF15]	17257745
C115461	SC 560	SC 560 results in increased expression of GDF15 mRNA	14633654
C115461	SC 560	SC 560 results in increased expression of GDF15 protein	14633654\|1550971
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of GDF15 mRNA	19564919
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of GDF15 mRNA"	24160326
C040115	shogaol	shogaol results in increased expression of GDF15 mRNA	25148906
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of GDF15 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of GDF15 mRNA	19073995\|2322117
D012834	Silver	Silver results in increased expression of GDF15 mRNA	27131904
C440975	silybin	EGR1 mutant form inhibits the reaction [silybin results in increased expression of GDF15 protein]	24440808
C440975	silybin	GDF15 mutant form inhibits the reaction [silybin results in increased cleavage of PARP1 protein]	24440808
C440975	silybin	pyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein]	24440808
C440975	silybin	SB 203580 inhibits the reaction [silybin results in increased expression of GDF15 protein]	24440808
C440975	silybin	silybin results in increased expression of GDF15 mRNA	24440808
C440975	silybin	silybin results in increased expression of GDF15 protein	24440808
C017947	sodium arsenite	[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter	18448484
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of GDF15 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in increased expression of GDF15 mRNA	23876855\|2587980
C017947	sodium arsenite	sodium arsenite results in increased expression of GDF15 protein	25879800
C017947	sodium arsenite	sodium arsenite results in increased expression of GDF15 mRNA	16014739
D015086	2,6-Dichloroindophenol	"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA"	21034357
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GDF15 mRNA	24383545
D053260	Soot	Soot results in increased expression of GDF15 mRNA	26551751
D013467	Sulindac	Sulindac results in increased expression of GDF15 mRNA	11906190
D013467	Sulindac	Sulindac results in increased expression of GDF15 protein	15180942
D013467	Sulindac	Sulindac results in increased expression of GDF15 protein	11984525
C025462	sulindac sulfide	EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]	15509713
C025462	sulindac sulfide	sulindac sulfide results in increased expression of GDF15 mRNA	15509713
C025462	sulindac sulfide	sulindac sulfide results in increased expression of GDF15 protein	11895857\|1192547
C025462	sulindac sulfide	sulindac sulfide results in increased expression of GDF15 mRNA	18076062
D013629	Tamoxifen	GDF15 protein results in decreased susceptibility to Tamoxifen	22615612
D013629	Tamoxifen	Tamoxifen affects the expression of GDF15 mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in increased expression of GDF15 mRNA	25123088
C003377	taxifolin	taxifolin results in increased expression of GDF15 mRNA	17541156
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]	20064835
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GDF15 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA	19619570\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GDF15 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GDF15 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]	23996089
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein	23996089
D019284	Thapsigargin	Thapsigargin results in increased expression of GDF15 mRNA	22378314
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein	18951874
D013853	Thioacetamide	Thioacetamide results in increased expression of GDF15 mRNA	23411599
D013883	Thiostrepton	Thiostrepton results in increased expression of GDF15 mRNA	22321511
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in increased expression of GDF15 mRNA	23825117
C009495	titanium dioxide	titanium dioxide results in increased expression of GDF15 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GDF15 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of GDF15 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of GDF15 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of GDF15 mRNA	25729387
D014212	Tretinoin	Tretinoin metabolite results in increased expression of GDF15 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of GDF15 mRNA	17045167
D014212	Tretinoin	Tretinoin results in increased expression of GDF15 mRNA	15982314\|2383079
D014241	Trichloroethylene	Trichloroethylene results in increased expression of GDF15 mRNA	25549359
C012589	trichostatin A	Cycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 mRNA]	18801729
C012589	trichostatin A	Cycloheximide inhibits the reaction [trichostatin A affects the expression of GDF15 protein]	18801729
C012589	trichostatin A	decitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 mRNA]	18801729\|1880172
C012589	trichostatin A	decitabine promotes the reaction [[trichostatin A affects the methylation of GDF15 promoter] which affects the expression of GDF15 protein]	18801729\|1880172
C012589	trichostatin A	EGR1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]	18801729
C012589	trichostatin A	SP1 protein affects the reaction [trichostatin A affects the expression of GDF15 mRNA]	18801729
C012589	trichostatin A	trichostatin A results in increased expression of GDF15 mRNA	24935251
C012589	trichostatin A	[trichostatin A results in increased expression of GDF15 protein] which results in increased cleavage of PARP1 protein	18801729
C012589	trichostatin A	[trichostatin A results in increased stability of GDF15 mRNA] which results in increased expression of GDF15 protein	18801729\|1880172
C050414	tripterine	tripterine results in increased expression of GDF15 mRNA	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GDF15 mRNA"	26179874
C057693	troglitazone	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of GDF15 protein]	14662774
C057693	troglitazone	Cycloheximide inhibits the reaction [troglitazone results in increased expression of GDF15 mRNA]	14662774
C057693	troglitazone	[EGR1 protein binds to GDF15 promoter] affects the reaction [troglitazone results in increased expression of GDF15]	14662774
C057693	troglitazone	troglitazone results in increased expression of GDF15 mRNA	14662774\|1914023
C057693	troglitazone	troglitazone results in increased expression of GDF15 protein	14662774\|2146157
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which affects the expression of GDF15 mRNA	20105288
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of GDF15 mRNA	28666766
D014415	Tunicamycin	Tunicamycin results in increased expression of GDF15 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of GDF15 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of GDF15 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of GDF15 mRNA	23179753\|2493525
C066075	vanadium pentoxide	vanadium pentoxide results in increased expression of GDF15 mRNA	17459161
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GDF15 gene	25560391
D014750	Vincristine	Vincristine results in increased expression of GDF15 mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of GDF15 mRNA	26682919
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in increased expression of GDF15 mRNA	23825117
D014800	Vitallium	Vitallium analog results in increased expression of GDF15 mRNA	23825117
D000225	Adenine	Adenine results in decreased expression of GDF15 mRNA	24211769
D024483	Vitamin K 3	Vitamin K 3 affects the expression of GDF15 mRNA	20044591
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GDF15 mRNA	12414654
C009687	wortmannin	wortmannin results in increased expression of GDF15 protein	23178381
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of GDF15 mRNA	18593933
D015032	Zinc	Zinc deficiency results in increased expression of GDF15 mRNA	19111725
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of GDF15 mRNA]	19111725
C088658	zoledronic acid	zoledronic acid results in decreased expression of GDF15 mRNA	24714768\|2559613

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	IBA	21873635
GO:0005160	transforming growth factor beta receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	19060904 25893289 28846098 28846099 28953886
GO:0008083	growth factor activity	-	IEA	-
GO:0042803	protein homodimerization activity	-	IDA	29046435

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	IDA	28953886
GO:0002023	reduction of food intake in response to dietary excess	-	IDA	28846097 28846098 28846099 28953886 29046435
GO:0007165	signal transduction	-	TAS	9326641
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	9348093
GO:0007267	cell-cell signaling	-	TAS	9326641
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	IBA	21873635
GO:0030509	BMP signaling pathway	-	IBA	21873635
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	-	IDA	28953886
GO:0040015	negative regulation of multicellular organism growth	-	ISS	-
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0043408	regulation of MAPK cascade	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IMP	28846099
GO:0048468	cell development	-	IBA	21873635
GO:0051897	positive regulation of protein kinase B signaling	-	IDA	28846097
GO:0051897	positive regulation of protein kinase B signaling	-	IMP	28846099
GO:0060395	SMAD protein signal transduction	-	IBA	21873635
GO:0060395	SMAD protein signal transduction	-	IDA	25893289
GO:0060400	negative regulation of growth hormone receptor signaling pathway	-	ISS	-
GO:1901741	positive regulation of myoblast fusion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	28572090 29046435
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	25893289
GO:0005634	nucleus	-	IDA	25893289
GO:0005737	cytoplasm	-	IDA	25893289
GO:0005794	Golgi apparatus	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26090487	GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis. (2015)	Amaya-Amaya J	J Immunol Res
25721048	Genetic variants in TNFalpha, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. (2016)	Yucesoy B	J Immunotoxicol
22997280	Clinical and genetic correlates of growth differentiation factor 15 in the community. (2012 Nov)	Ho JE	Clin Chem
18657084	Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors. (2008 Oct)	Mast AE	Transfusion
19505289	The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension. (2009 Oct 19)	Wang X	Clin Sci (Lond)
28798540	Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors. (2017)	Hsu LA	Mediators Inflamm
28298399	Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD. (2017 Mar)	Husebo GR	Eur Respir J
28898507	Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)	Koo BK	Liver Int