Gene: CD38

952
ADPRC 1|ADPRC1
CD38 molecule
protein-coding
4p15.32
Ensembl:ENSG00000004468 MIM:107270 Vega:OTTHUMG00000048206 UniprotKB:P28907
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.872e-1 (AD)  8.836e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04332373chr4:15779642CD387.600e-11Smoking27651444
cg04811945chr4:15779709CD386.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MASP10.769
ANKFN10.735
IL330.727
DPH60.726
BMPR1B0.714
FIBIN0.713
DHTKD10.713
NPAS30.713
EFEMP10.703
F30.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MIP-0.441
FAM160A1-0.441
KLRG1-0.44
TUBA8-0.429
CACNA1F-0.425
KLHL38-0.421
MUM1L1-0.416
KIAA1549-0.413
B3GNT4-0.396
AGMAT-0.389

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09331DaratumumabBiotechDrug945721-28-8ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CD38 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CD38 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CD38 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of CD38 mRNA"23829299
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]16329108
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ro 25-6603 results in increased expression of CD38 protein]16329108
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of CD38 protein]"17077328
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]22556157
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]22556157
C5847872-acetylphenothiazine2-acetylphenothiazine inhibits the reaction [VAV2 protein affects the localization of CD38 protein]23940720
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD38 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD38 mRNA"25380136
C0030017-ketocholesterolCD38 gene mutant form promotes the reaction [7-ketocholesterol results in increased expression of MAP1LC3B protein]24445604
D020106AcrylamideAcrylamide results in increased expression of CD38 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD38 gene27153756
C103303alitretinoinalitretinoin results in increased expression of CD38 mRNA15964820|2139341
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]15964820
C103303alitretinoinperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]15964820
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CD38 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CD38 mRNA21298039
C068073Am 5802-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein]16329108
C068073Am 580Am 580 results in increased expression of CD38 protein16329108
C068073Am 580[Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein16329108
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD38 mRNA16483693
D000968Antimycin AAntimycin A results in increased expression of CD38 mRNA10491287
D001151ArsenicArsenic results in decreased expression of CD38 mRNA19654921
C006632arsenic trioxideCD38 results in increased susceptibility to arsenic trioxide18297255
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of CD38 mRNA"24160326
D001542BenomylBenomyl results in decreased expression of CD38 mRNA15885261
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CD38 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD38 mRNA18164116
D004958EstradiolCD38 affects the abundance of Estradiol21840325
C006780bisphenol Abisphenol A results in decreased expression of CD38 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CD38 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of CD38 mRNA20977926
D002118CalciumCD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium]20200208
D002118CalciumCD38 protein inhibits the reaction [CD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium]]20200208|2020020
D002737ChloropreneChloroprene results in decreased expression of CD38 mRNA23125180
C418118CI 1044CI 1044 results in increased expression of CD38 mRNA17569694
D009249NADPCD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]20200208
D009249NADPCD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]20200208
C029892cupric chloridecupric chloride results in decreased expression of CD38 mRNA24650576
D036563Cyclic ADP-RiboseCD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose23343681
D036563Cyclic ADP-RiboseCD38 protein results in increased chemical synthesis of Cyclic ADP-Ribose22556157
D003513CycloheximideCycloheximide affects the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D003520CyclophosphamideCyclophosphamide results in increased expression of CD38 mRNA21041162
D003606Dacarbazine[Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein11583285
D003606Dacarbazine[Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD38 protein14669796
D003606DacarbazineDacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein]16078447
D000069439DasatinibDasatinib results in decreased expression of CD38 protein17962511
D064791Desoxycorticosterone AcetateCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]21992601
D064791Desoxycorticosterone AcetateCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]21992601
D003907DexamethasoneDexamethasone results in increased expression of CD38 mRNA21041162
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CD38 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CD38 mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of CD38 mRNA15885261
D004041Dietary FatsDietary Fats results in decreased expression of CD38 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD38 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD38 mRNA21041162
D002117CalcitriolCalcitriol results in increased expression of CD38 mRNA16329108
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CD38 mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]15964820
D004121Dimethyl Sulfoxideperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]15964820
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein]23940720
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein]23940720
D004317DoxorubicinDoxorubicin results in decreased expression of CD3816878501
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CD38 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD38 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD38 mRNA17942748
C004912ethylbenzeneethylbenzene results in increased expression of CD38 mRNA20955722
D005419FlavonoidsFlavonoids results in increased expression of CD38 mRNA18035473
D005472FluorouracilFluorouracil affects the expression of CD38 mRNA16584549
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in decreased expression of AR mRNA]21840325
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in decreased expression of MYH7 mRNA]21840325
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in increased expression of MYH6 mRNA]21840325
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in increased expression of RYR2 mRNA]21840325
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in increased expression of SLC8A1 mRNA]21840325
D005485FlutamideFlutamide results in decreased expression of CD38 mRNA15885261|2413618
D004397FonofosFonofos results in increased methylation of CD38 promoter22847954
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein15494208
D009240N-Formylmethionine Leucyl-PhenylalanineSB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein]15494208
C546771gardiquimodgardiquimod results in increased expression of CD38 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD38 mRNA]28003376
D019833GenisteinGenistein results in increased expression of CD38 mRNA22553218
D005839GentamicinsGentamicins results in increased expression of CD38 mRNA22061828
C004312glycidolglycidol results in decreased expression of CD38 mRNA24915197
D017313FenretinideFenretinide results in increased expression of CD38 mRNA28973697
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"CD38 gene mutant form inhibits the reaction [FASL protein results in increased activity of 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"20200208
C016517indole-3-carbinolindole-3-carbinol affects the expression of CD38 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD38 mRNA25613284
D007539Isonicotinic AcidsIsonicotinic Acids results in increased expression of CD38 protein12951526
D007545IsoproterenolIsoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein]23343681
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CD38 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CD38 mRNA16835149
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD38 mRNA23086925|2638794
D007649KetamineKetamine results in increased expression of CD38 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD38 mRNA22235868
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD38 mRNA27339419
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [EDN1 protein affects the localization of CD38 protein]23940720
D008752Methylene ChlorideMethylene Chloride results in increased expression of CD38 mRNA20955722
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD38 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CD38 mRNA26924002
D009020MorphineCD38 affects the susceptibility to Morphine20551293
C024376NAADPCD38 gene mutant form inhibits the reaction [FASL protein results in increased abundance of NAADP]20200208
C024376NAADPCD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]20200208
C024376NAADPCD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]20200208
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD38 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CD38 mRNA25380136
D009532NickelNickel results in increased expression of CD38 mRNA24768652
D009675NovobiocinNovobiocin results in increased expression of CD38 mRNA11853877
D009675NovobiocinNovobiocin results in increased expression of CD38 protein11853877
D009840OligomycinsOligomycins results in increased expression of CD38 mRNA10491287
D000073878Palm OilPalm Oil results in decreased expression of CD38 mRNA18042831
C016030pantogabpantogab results in increased expression of CD38 mRNA17379144
D010269ParaquatParaquat results in decreased expression of CD38 mRNA18198484
D010278ParathionParathion results in increased methylation of CD38 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of CD38 mRNA23638009
D010396PenicillaminePenicillamine results in increased expression of CD38 mRNA19575532
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of CD38 mRNA28973697
C027579periodate-oxidized adenosineperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]15964820
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CD38 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CD38 mRNA19482888
C549211PIK 75PIK 75 inhibits the reaction [TNF protein results in increased activity of CD38 protein]22556157
D011374Progesterone[Progesterone co-treated with TGFB1 protein] results in increased expression of CD38 mRNA21768398
D011374ProgesteroneProgesterone results in increased expression of CD38 mRNA21768398
D011374ProgesteroneProgesterone results in increased expression of CD38 mRNA21770760
D011441PropylthiouracilPropylthiouracil affects the expression of CD38 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD38 mRNA]28003376
C012526quercitrinquercitrin results in decreased expression of CD38 mRNA25193878
C059514resveratrolresveratrol results in increased expression of CD38 mRNA18089832|2588880
C059514resveratrolresveratrol results in increased expression of CD38 protein18089832
D015474IsotretinoinIsotretinoin results in increased expression of CD38 protein16275619
C097599Ro 25-66032-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ro 25-6603 results in increased expression of CD38 protein]16329108
C097599Ro 25-6603[Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein16329108
C097599Ro 25-6603Ro 25-6603 results in increased expression of CD38 protein16329108
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D012402RotenoneRotenone results in increased expression of CD38 mRNA10491287
D012402RotenoneRotenone results in increased expression of CD38 protein8833408
C085746rottlerinrottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
C085746rottlerinrottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein]21393419
C093642SB 203580SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein]15494208
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CD38 mRNA25895662
D020123SirolimusCD38 gene mutant form promotes the reaction [Sirolimus results in increased expression of MAP1LC3B protein]24445604
D020123SirolimusCD38 mutant form inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]24238063
D012965Sodium ChlorideCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]21992601
D012965Sodium ChlorideCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]21992601
D012982Sodium, Dietary"CD38 gene mutant form promotes the reaction [Sodium, Dietary deficiency results in increased activity of REN protein]"23343681
D012999SomanSoman results in increased expression of CD38 mRNA19281266
D053260SootSoot results in decreased expression of CD38 mRNA26551751
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of CD38 mRNA16214533
D013481SuperoxidesSuperoxides affects the localization of CD38 protein23940720
D013481Superoxidestempol inhibits the reaction [Superoxides affects the localization of CD38 protein]23940720
C061133tamibarotenetamibarotene results in increased expression of CD38 mRNA15498508|2139341
C061133tamibarotenetamibarotene results in increased expression of CD38 protein21393419
D013629TamoxifenTamoxifen affects the expression of CD38 mRNA17555576
C001803tempoltempol inhibits the reaction [Superoxides affects the localization of CD38 protein]23940720
C012568terbufosterbufos results in increased methylation of CD38 promoter22847954
D013739TestosteroneCD38 affects the abundance of Testosterone21840325
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD38 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD38 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD38 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD38 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CD38 mRNA16343077
D013853ThioacetamideThioacetamide results in increased expression of CD38 protein16343077
C009495titanium dioxidetitanium dioxide results in decreased expression of CD38 mRNA23557971
D019772TopotecanTopotecan results in increased expression of CD38 mRNA25729387
D014212Tretinoin"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of CD38 protein]"17077328
D014212TretinoinCycloheximide affects the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D014212TretinoinPRKCD mutant form inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D014212TretinoinPTK2 protein inhibits the reaction [Tretinoin results in increased expression of CD38 protein]16226872
D014212TretinoinRo 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D014212Tretinoinrottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]21393419
D014212Tretinoinrottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein]21393419
D014212TretinoinTretinoin results in increased expression of CD38 mRNA15498508|1605412
D014212TretinoinTretinoin results in increased expression of CD38 protein16226872|1627561
D014212TretinoinTretinoin results in increased expression of CD38 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of CD38 mRNA20955722
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CD38 mRNA19042947
C025643vinclozolinvinclozolin affects the expression of CD38 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of CD38 mRNA23034163
D009536NiacinamideCD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]20200208
D015032ZincZinc deficiency results in increased expression of CD38 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003953NAD+ nucleosidase activity-IBA21873635  
GO:0003953NAD+ nucleosidase activity-TAS-  
GO:0016740transferase activity-IEA-  
GO:0016849phosphorus-oxygen lyase activity-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO:0050135NAD(P)+ nucleosidase activity-IEA-  
GO:0061809NAD+ nucleotidase, cyclic ADP-ribose generating-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0007165signal transduction-NAS8253715  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0014824artery smooth muscle contraction-IEA-  
GO:0019674NAD metabolic process-TAS-  
GO:0030307positive regulation of cell growth-IEA-  
GO:0030890positive regulation of B cell proliferation-IBA21873635  
GO:0030890positive regulation of B cell proliferation-IMP17875758  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0033194response to hydroperoxide-IEA-  
GO:0042493response to drug-IMP17875758  
GO:0043066negative regulation of apoptotic process-IMP17875758  
GO:0045779negative regulation of bone resorption-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP17875758  
GO:0045893positive regulation of transcription, DNA-templated-IMP17875758  
GO:0045907positive regulation of vasoconstriction-IEA-  
GO:0050853B cell receptor signaling pathway-IMP17875758  
GO:0060292long term synaptic depression-IEA-  
GO:0070555response to interleukin-1-IEA-  
GO:0097190apoptotic signaling pathway-TAS10777496  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0016020membrane-TAS8253715  
GO:0016021integral component of membrane-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0030667secretory granule membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04640Hematopoietic cell lineage
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11422406Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytes. (2001 Jun)Bijl MEur J Clin Invest
17893969Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients. (2007 Jun)Sailler LAnn N Y Acad Sci
24842313Tobacco smoking increases immune activation and impairs T-cell function in HIV infected patients on antiretrovirals: a cross-sectional pilot study. (2014)Valiathan RPLoS One
11852118Lymphocyte phenotype analysis and chromosome aberration frequency of workers occupationally exposed to styrene, benzene, polycyclic aromatic hydrocarbons or mixed solvents. (2002 Apr 22)Biro AImmunol Lett
15644129Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjogren's syndrome and healthy subjects. (2005 Jan)Larsson AScand J Immunol
27527002Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV. (2017 Feb)Grome HNAIDS Res Hum Retroviruses
23559466Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy. (2013 Jul 15)Erlandson KMJ Infect Dis
25397464Relationship between innate immunity, soluble markers and metabolic-clinical parameters in HIV+ patients ART treated with HIV-RNA<50 cp/mL. (2014)Dentone CJ Int AIDS Soc
26075746Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. (2015)Wylam MEPLoS One
20505494Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection. (2010 Jun 19)Ford ESAIDS
26110892Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. (2015 Jul)Aslibekyan SObesity (Silver Spring)
28518151Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kappaB and Nrf2. (2017 May 18)Xu BCell Death Dis
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