Gene: ENTPD1

953
ATPDase|CD39|NTPDase-1|SPG64
ectonucleoside triphosphate diphosphohydrolase 1
protein-coding
10q24.1
Ensembl:ENSG00000138185 MIM:601752 Vega:OTTHUMG00000018818 UniprotKB:P49961
NG_042803.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.382e-1 (AD)  8.210e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3949478chr10:95713457 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCOA30.808
PBRM10.807
RCBTB20.799
SCAF110.797
PCMTD10.795
SOS10.794
AP3M10.794
CREB10.79
CTTNBP2NL0.79
GNS0.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.522
OR4F29-0.508
LRRC26-0.173
OR5K3-0.167
NUTM2E-0.167
MUC12-0.164
APOA4-0.162
CFC1B-0.155
TMEM114-0.152
HES6-0.152

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C44865917-(dimethylaminoethylamino)-17-demethoxygeldanamycin17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]27899277
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ENTPD1 mRNA"20566336
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ENTPD1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ENTPD1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ENTPD1 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased methylation of ENTPD1 gene"26018793
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of ENTPD1 mRNA"26018793
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ENTPD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ENTPD1 mRNA24449571
D001151ArsenicArsenic affects the methylation of ENTPD1 gene25304211
D001374AzacitidineAzacitidine results in increased expression of ENTPD1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ENTPD1 mRNA21185374
D004958EstradiolEstradiol results in increased expression of ENTPD1 mRNA19619570
C006780bisphenol Abisphenol A results in increased expression of ENTPD1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of ENTPD1 mRNA25181051
D000074262Canola OilCanola Oil metabolite results in decreased expression of ENTPD1 mRNA27363782
D000068579CelecoxibCelecoxib results in decreased expression of ENTPD1 mRNA28201806
C086276cerivastatincerivastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]12067895
C018021cobaltous chloridecobaltous chloride results in increased expression of ENTPD1 protein27899277
D019327Copper SulfateCopper Sulfate results in decreased activity of ENTPD1 mRNA17499414
D019327Copper SulfateCopper Sulfate results in decreased expression of ENTPD1 mRNA17499414
D003561CytarabineCytarabine results in increased expression of ENTPD1 mRNA19194470
C107676deguelindeguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]27899277
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ENTPD1 mRNA]27941970
C023614dibenzofurandibenzofuran analog results in increased expression of ENTPD1 mRNA20566336
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ENTPD1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENTPD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ENTPD1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ENTPD1 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of ENTPD1 mRNA21852083
D004237DiuronDiuron results in decreased expression of ENTPD1 mRNA25152437
D004237DiuronDiuron results in increased expression of ENTPD1 mRNA21551480
C118739entinostatentinostat results in increased expression of ENTPD1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of ENTPD1 mRNA17698255
D000431EthanolEthanol results in increased expression of ENTPD1 mRNA21704070
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene26018793
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA26018793
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ENTPD1 mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of ENTPD1 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of ENTPD1 mRNA19219653
D005557FormaldehydeFormaldehyde results in decreased expression of ENTPD1 mRNA23649840
D007545IsoproterenolIsoproterenol results in increased expression of ENTPD1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ENTPD1 mRNA27392435
D007854LeadLead results in increased expression of ENTPD1 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ENTPD1 mRNA"24972896
D008070LipopolysaccharidesENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]24685903
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ENTPD1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ENTPD1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ENTPD1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ENTPD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ENTPD1 mRNA"25554681
D009532NickelNickel results in increased expression of ENTPD1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of ENTPD1 mRNA16780908
D010100Oxygen17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]27899277
D010100Oxygendeguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]27899277
D010100OxygenHIF1A protein affects the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]27899277
D010100OxygenOxygen deficiency results in increased expression of ENTPD1 mRNA27899277
D010100OxygenOxygen deficiency results in increased expression of ENTPD1 protein27899277
D010100OxygenOxygen deficiency results in increased expression of ENTPD1 mRNA23437309
D010100OxygenOxygen deficiency results in increased expression of ENTPD1 protein23437309
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ENTPD1 mRNA26705709
C046012pentanalpentanal results in increased expression of ENTPD1 mRNA26079696
C006253pirinixic acidpirinixic acid results in decreased expression of ENTPD1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of ENTPD1 mRNA17690133
D011374ProgesteroneProgesterone results in decreased expression of ENTPD1 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of ENTPD1 mRNA19690047
C059514resveratrolresveratrol results in decreased expression of ENTPD1 mRNA23419489
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of ENTPD1 mRNA21852083
D012822Silicon DioxideENTPD1 protein inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]24793913
D012822Silicon DioxideENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]24685903
D019821SimvastatinSimvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]12067895
C017947sodium arsenitesodium arsenite results in decreased methylation of ENTPD1 gene24570342
D012999SomanSoman results in increased expression of ENTPD1 mRNA19281266
D053260SootSoot results in increased expression of ENTPD1 mRNA26551751
C004648testosterone enanthatetestosterone enanthate affects the expression of ENTPD1 mRNA17440010
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENTPD1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENTPD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENTPD1 mRNA26377647
D013853ThioacetamideENTPD1 protein results in decreased susceptibility to Thioacetamide27899277
D013853ThioacetamideThioacetamide results in increased expression of ENTPD1 mRNA27899277
D013853ThioacetamideThioacetamide results in increased expression of ENTPD1 protein27899277
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene26018793
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA26018793
D014118Toxins, Biological"Toxins, Biological affects the expression of ENTPD1 mRNA"19682533
C012589trichostatin Atrichostatin A results in decreased expression of ENTPD1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of ENTPD1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ENTPD1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of ENTPD1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENTPD1 gene25560391
D014810Vitamin EVitamin E results in increased expression of ENTPD1 mRNA19244175
C111237vorinostatvorinostat results in increased expression of ENTPD1 mRNA20060208
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene26018793
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA26018793

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16478441  
GO:0005524ATP binding-IEA-  
GO:0017110nucleoside-diphosphatase activity-EXP8955160  
GO:0017111nucleoside-triphosphatase activity-EXP8955160  
GO:0102485dATP phosphohydrolase activity-IEA-  
GO:0102486dCTP phosphohydrolase activity-IEA-  
GO:0102487dUTP phosphohydrolase activity-IEA-  
GO:0102488dTTP phosphohydrolase activity-IEA-  
GO:0102489GTP phosphohydrolase activity-IEA-  
GO:01024908-oxo-dGTP phosphohydrolase activity-IEA-  
GO:0102491dGTP phosphohydrolase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-NAS7930580  
GO:0007596blood coagulation-TAS8955160  
GO:0034656nucleobase-containing small molecule catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7930580  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-8850843Phosphate bond hydrolysis by NTPDase proteinsTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal