Gene: BAG4

9530
BAG-4|SODD
BCL2 associated athanogene 4
protein-coding
8p11.23
Ensembl:ENSG00000156735 MIM:603884 Vega:OTTHUMG00000164064 UniprotKB:O95429
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.429e-1 (AD)  7.258e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAP1L20.97
AASDHPPT0.968
SCAMP10.964
PRKAR2B0.961
ANKRD460.96
NPTN0.96
PREPL0.96
LRP110.957
UBE2K0.956
SLC9A60.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.536
CSAG1-0.492
OR4F29-0.486
RAI14-0.436
MAGEA12-0.432
FZD10-0.427
CNN2-0.418
HEY2-0.414
RUNX3-0.402
TFPI2-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BAG4 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of BAG4 mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of BAG4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BAG4 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of BAG4 mRNA21298039
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of BAG4 mRNA15240111
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of BAG4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BAG4 mRNA20504355
D019207beta Carotenebeta Carotene results in decreased expression of BAG4 mRNA17034753
D004958EstradiolEstradiol affects the expression of BAG4 mRNA22574217
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BAG4 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of BAG4 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BAG4 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of BAG4 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of BAG4 mRNA24066056|2518105
C006780bisphenol Abisphenol A results in increased methylation of BAG4 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BAG4 mRNA28628672
D002122Calcium ChlorideCalcium Chloride results in increased expression of BAG4 protein25824407
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BAG4 mRNA15963578
D002746ChlorpromazineChlorpromazine analog results in decreased expression of BAG4 mRNA15924885
D019327Copper SulfateCopper Sulfate results in decreased expression of BAG4 mRNA21595052
D016572CyclosporineCyclosporine results in decreased expression of BAG4 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BAG4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BAG4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BAG4 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BAG4 mRNA17361019|2126653
D004041Dietary FatsDietary Fats results in decreased expression of BAG4 mRNA18042831
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BAG4 gene23968726
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BAG4 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG4 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BAG4 mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of BAG4 mRNA20655997
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of BAG4 gene28505145
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BAG4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BAG4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BAG4 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of BAG4 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BAG4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BAG4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BAG4 mRNA28628672
D000073878Palm OilPalm Oil results in decreased expression of BAG4 mRNA18042831
D010269ParaquatParaquat results in increased expression of BAG4 mRNA18836921
D010416PentachlorophenolPentachlorophenol results in increased expression of BAG4 mRNA24642059
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of BAG4 gene23968726
C006253pirinixic acidpirinixic acid results in increased expression of BAG4 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BAG4 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of BAG4 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of BAG4 mRNA21770760
C030984pyrenepyrene results in decreased expression of BAG4 mRNA15963578
D011748PyrogallolPyrogallol results in decreased expression of BAG4 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in decreased expression of BAG4 mRNA]20362636
D011794QuercetinQuercetin results in decreased expression of BAG4 mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of BAG4 mRNA29191790
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in decreased expression of BAG4 mRNA]20362636
C009277sodium arsenatesodium arsenate results in increased expression of BAG4 mRNA21795629
D019311StaurosporineStaurosporine results in decreased expression of BAG4 protein19352495
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BAG4 mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of BAG4 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased expression of BAG4 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the expression of BAG4 mRNA23940539

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000774adenyl-nucleotide exchange factor activity-TAS-  
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI25036637  26496610  27107012  29568061  
GO:0031625ubiquitin protein ligase binding-IPI24270810  
GO:0051087chaperone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-TAS9873016  
GO:0010763positive regulation of fibroblast migration-IEA-  
GO:0030838positive regulation of actin filament polymerization-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0043066negative regulation of apoptotic process-TAS9915703  
GO:0045785positive regulation of cell adhesion-IEA-  
GO:0051291protein heterooligomerization-IEA-  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0071356cellular response to tumor necrosis factor-IDA21712384  
GO:0071364cellular response to epidermal growth factor stimulus-IEA-  
GO:0072659protein localization to plasma membrane-IEA-  
GO:0090367negative regulation of mRNA modification-IEA-  
GO:0097178ruffle assembly-IEA-  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1903215negative regulation of protein targeting to mitochondrion-IMP24270810  
GO:2001145negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21712384  
GO:0005829cytosol-IDA21712384  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA21712384  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS
R-HSA-8853336Signaling by plasma membrane FGFR1 fusionsTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24850843FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)Wang RClin Cancer Res