Gene: BAG3

9531
BAG-3|BIS|CAIR-1|MFM6
BCL2 associated athanogene 3
protein-coding
10q26.11
Ensembl:ENSG00000151929 MIM:603883 Vega:OTTHUMG00000019155 UniprotKB:O95817
NG_016125.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.036e-1 (AD)  8.406e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs196335chr10:119652349 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10673740chr10:121411826BAG31.050e-9Maternal smoking in pregnancy27040690
cg10673740chr10:121411826BAG31.920e-10Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPB10.848
ABHD30.838
SERPINH10.837
NFKB20.835
CSF10.834
TGIF10.833
TNFRSF1A0.82
PXDC10.815
CASP70.815
P4HA10.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.551
SLC7A4-0.548
CNTN6-0.537
CASC15-0.531
HAPLN1-0.525
NXPH2-0.522
SAMD5-0.52
ABCC12-0.518
GPR61-0.514
AGMAT-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of BAG3 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAG3 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BAG3 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BAG3 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BAG3 mRNA"21346803
C0127962-butenal2-butenal results in increased expression of BAG3 mRNA20471460
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in increased expression of BAG3 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BAG3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of BAG3 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
C501332ABT-737BAG3 mutant form inhibits the reaction [MCL1 protein results in decreased susceptibility to ABT-737]23341456
C501332ABT-737BAG3 protein results in decreased susceptibility to ABT-73723341456
C501332ABT-737[BAG3 protein results in increased stability of MCL1 protein] which results in decreased susceptibility to ABT-73723341456
D000082AcetaminophenAcetaminophen results in increased expression of BAG3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of BAG3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of BAG3 mRNA18544908|2917498
D000082AcetaminophenAcetaminophen results in increased expression of BAG3 protein29174983
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of BAG3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BAG3 mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of BAG3 mRNA17202762
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]18723479
D020106AcrylamideAcrylamide results in decreased expression of BAG3 mRNA28959563
D015766Albendazole[Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA16861626
D000638AmiodaroneAmiodarone results in decreased expression of BAG3 mRNA17991464
D001151ArsenicArsenic affects the expression of BAG3 mRNA18414638
C006632arsenic trioxidearsenic trioxide affects the expression of BAG3 mRNA17530438
C015001arsenitearsenite results in decreased expression of BAG3 mRNA18585952
C015001arseniteXPA protein affects the reaction [arsenite results in decreased expression of BAG3 mRNA]18585952
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of BAG3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BAG3 mRNA20106945|2163298
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]19352495
D019207beta Carotenebeta Carotene results in decreased expression of BAG3 mRNA17034753
D004958EstradiolEstradiol results in decreased expression of BAG3 mRNA21185374|2337363
D004958EstradiolEstradiol results in increased expression of BAG3 mRNA20106945|2301914
D004958EstradiolEstradiol affects the expression of BAG3 mRNA15598610
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of BAG3 protein21127259
C006780bisphenol Abisphenol A affects the expression of BAG3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of BAG3 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of BAG3 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of BAG3 mRNA24247028
D000069286BortezomibBortezomib results in increased expression of BAG3 mRNA15509775|1765933
C546611brevetoxin 2brevetoxin 2 results in increased expression of BAG3 mRNA20498034
C013418bromfenacoumbromfenacoum results in decreased expression of BAG3 protein28903499
C584509C646 compoundC646 compound results in increased expression of BAG3 mRNA26191083
D002104CadmiumCadmium results in increased expression of BAG3 mRNA21120746|2428428
D019256Cadmium ChlorideCadmium Chloride results in increased expression of and affects the localization of BAG3 protein12706811
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BAG3 mRNA12706811
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BAG3 mRNA19010381
C037123cadmium sulfatecadmium sulfate results in increased expression of BAG3 mRNA16221973
D002211CapsaicinCapsaicin results in increased expression of BAG3 mRNA19502594
D002220CarbamazepineCarbamazepine affects the expression of BAG3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BAG3 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of BAG3 mRNA18500788
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of BAG3 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of BAG3 mRNA26352163
D002922CiguatoxinsCiguatoxins affects the expression of BAG3 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of BAG3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BAG3 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of BAG3 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of BAG3 mRNA24386269
D003042CocaineCocaine affects the expression of BAG3 mRNA15681117
D003042CocaineCocaine results in increased expression of BAG3 mRNA27899881
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of BAG3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BAG3 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of BAG3 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of BAG3 mRNA17211630
D003471CuprizoneCuprizone results in decreased expression of BAG3 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of BAG3 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of BAG3 mRNA21198554
D003609DactinomycinDactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
C014347decitabinedecitabine affects the expression of BAG3 mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in increased expression of BAG3 mRNA22846391
D003976DiazinonDiazinon affects the expression of BAG3 mRNA22546817
D002945CisplatinCisplatin affects the expression of BAG3 mRNA23300844
C000944dicrotophosdicrotophos results in increased expression of BAG3 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BAG3 mRNA26924002
D004026DieldrinDieldrin affects the expression of BAG3 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of BAG3 mRNA18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of BAG3 mRNA]18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of BAG3 mRNA]18691550
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA24690739
D004317DoxorubicinDoxorubicin affects the expression of BAG3 protein29385562
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of BAG3 mRNA"23811387
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]18723479
C512195elesclomolelesclomol results in increased expression of BAG3 mRNA18723479
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of BAG3 mRNA19118595
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BAG3 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG3 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BAG3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BAG3 mRNA17942748
C540355fenamidonefenamidone results in increased expression of BAG3 mRNA27029645
D005472FluorouracilBAG3 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in increased expression of BAG3 mRNA24136188
C106014geduningedunin results in increased expression of BAG3 mRNA17010675
D019833GenisteinGenistein results in increased expression of BAG3 mRNA23019147
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of BAG3 mRNA15046208
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAG3 mRNA25613284
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA16861626
D007608Kainic AcidKainic Acid results in increased expression of BAG3 mRNA19700661
D007649KetamineKetamine results in increased expression of BAG3 mRNA20080153
C045463leflunomideleflunomide results in decreased expression of BAG3 mRNA28988120
D008070Lipopolysaccharides3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
D008070Lipopolysaccharides3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
D008070LipopolysaccharidesDactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [SP1 protein binds to BAG3 promoter]22020323
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of BAG3 mRNA22020323
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of BAG3 protein22020323
D008070LipopolysaccharidesMAPK8 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
D008070LipopolysaccharidesNFKBIA gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BAG3 mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of BAG3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of BAG3 mRNA16507785
D019216Metals, Heavy"Metals, Heavy results in increased expression of BAG3"17187345
D008727MethotrexateMethotrexate affects the expression of BAG3 mRNA18502557
C005219methyl cellosolvemethyl cellosolve results in increased expression of BAG3 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BAG3 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BAG3 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of BAG3 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of BAG3 protein26558463
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of BAG3 mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BAG3 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BAG3 mRNA26924002
D009020MorphineMorphine results in increased expression of BAG3 protein23056601
C437683motexafin gadoliniummotexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of BAG3 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BAG3 mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of BAG3 mRNA23811387
C051752nefazodonenefazodone results in increased expression of BAG3 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of BAG3 mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BAG3 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BAG3 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BAG3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BAG3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BAG3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BAG3 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BAG3 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of BAG3 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BAG3 mRNA]17655762
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of BAG3 mRNA18593933
C568608PCI 5002PCI 5002 results in increased expression of BAG3 mRNA18593933
D010634PhenobarbitalPhenobarbital results in increased expression of BAG3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BAG3 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of BAG3 mRNA21061450
D010938Plant OilsPlant Oils results in increased expression of BAG3 mRNA23370395
C013649plastochromanol 8plastochromanol 8 results in increased expression of BAG3 protein23941772
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BAG3 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of BAG3 mRNA18037150
C045950propiconazolepropiconazole results in increased expression of BAG3 mRNA19363144|2127805
C513428pyrachlostrobinpyrachlostrobin results in increased expression of BAG3 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]22020323
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein]22020323
C031280pyrazolepyrazole results in increased expression of BAG3 mRNA17945193
D012402RotenoneRotenone results in increased expression of BAG3 mRNA23186747
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of BAG3 mRNA"16678137
D012822Silicon DioxideSilicon Dioxide results in increased expression of BAG3 mRNA23221170
D012834SilverSilver results in increased expression of BAG3 mRNA26014281|2895954
C017947sodium arsenitesodium arsenite results in increased expression of BAG3 mRNA24516582
C017947sodium arsenitesodium arsenite results in increased expression of BAG3 mRNA16014739
D012999SomanSoman results in increased expression of BAG3 mRNA19281266
C525423SRT2183SRT2183 results in increased expression of BAG3 mRNA23681230
D019311StaurosporineBAG3 protein results in decreased susceptibility to Staurosporine19352495
D019311Staurosporinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]19352495
D019311StaurosporineStaurosporine results in decreased expression of BAG3 protein19352495
D019311StaurosporineStaurosporine results in increased degradation of and results in increased ubiquitination of BAG3 protein19352495
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BAG3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BAG3 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of BAG3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BAG3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAG3 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of BAG3 mRNA16870260
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BAG3 mRNA22363418|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BAG3 mRNA25729387
C011559tributyltintributyltin affects the expression of BAG3 mRNA27678064
C050414tripterinetripterine results in increased expression of BAG3 mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAG3 mRNA"26743178
D014520UrethaneUrethane results in increased expression of BAG3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAG3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BAG3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BAG3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of BAG3 mRNA17292431|1796380
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BAG3 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of BAG3 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BAG3 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased expression of BAG3 mRNA19465080
C025643vinclozolinvinclozolin results in decreased expression of BAG3 mRNA21126777
C025643vinclozolinvinclozolin affects the expression of BAG3 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of BAG3 mRNA23034163
D014800VitalliumVitallium analog results in increased expression of BAG3 mRNA23825117
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of BAG3 mRNA18593933
D015032ZincZinc results in increased expression of BAG3 mRNA16870260
D019345Zinc Acetatemotexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of BAG3 mRNA16357179
C016837zinc chloridezinc chloride results in increased expression of and affects the localization of BAG3 protein12706811
C016837zinc chloridezinc chloride results in increased expression of BAG3 mRNA12706811|1687026
C088658zoledronic acidzoledronic acid results in increased expression of BAG3 mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000774adenyl-nucleotide exchange factor activity-IDA20060297  24318877  
GO:0000774adenyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI16189514  19229298  21044950  21516116  22366786  24318877  
24510904  25036637  25277244  25416956  26159920  26496610  
27173435  28144995  
GO:0044877protein-containing complex binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0051087chaperone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-NAS9873016  
GO:0007420brain development-IEA-  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IDA10597216  
GO:0010664negative regulation of striated muscle cell apoptotic process-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0034605cellular response to heat-IDA26159920  
GO:0042307positive regulation of protein import into nucleus-IMP26159920  
GO:0043066negative regulation of apoptotic process-NAS10597216  
GO:0046827positive regulation of protein export from nucleus-IMP26159920  
GO:0050790regulation of catalytic activity-IEA-  
GO:0050821protein stabilization-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO:0097201negative regulation of transcription from RNA polymerase II promoter in response to stress-IMP26159920  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1903215negative regulation of protein targeting to mitochondrion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA26159920  
GO:0005737cytoplasm-IDA26159920  
GO:0005829cytosol-IDA10597216  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0030018Z disc-IEA-  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23981442Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)McClintick JNAlcohol