Gene: EI24

9538
EPG4|PIG8|TP53I8
EI24, autophagy associated transmembrane protein
protein-coding
11q24.2
Ensembl:ENSG00000149547 MIM:605170 Vega:OTTHUMG00000165851 UniprotKB:O14681
NG_032933.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.555e-1 (AD)  8.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2D20.944
RNF100.941
EIF4G20.933
STRAP0.932
YWHAQ0.93
EIF4H0.928
UBA20.927
C1orf430.926
EIF4A20.924
PSMD70.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.803
OR4F29-0.799
C8orf74-0.222
MTRNR2L6-0.207
MTRNR2L10-0.194
SLC2A4-0.188
EN1-0.184
CXCR2-0.183
VNN3-0.182
KCNK5-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of EI24 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EI24 mRNA28329830
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of EI24 mRNA21983209
D000082AcetaminophenAcetaminophen results in increased expression of EI24 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EI24 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EI24 mRNA]17585979
D000111AcetylcysteineAcetylcysteine promotes the reaction [Tobacco Smoke Pollution results in increased expression of EI24 mRNA]16137721
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EI24 mRNA22100608
D004999AmifostineAmifostine results in decreased expression of EI24 mRNA14555708
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EI24 mRNA24449571
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of EI24 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EI24 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EI24 mRNA19770486|2261060
D001663BilirubinBilirubin results in decreased expression of EI24 mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of EI24 mRNA25181051
D002065BuspironeBuspirone results in increased expression of EI24 mRNA24136188
D002166CamptothecinCamptothecin results in increased expression of EI24 mRNA17374387
D002994ClofibrateClofibrate results in increased expression of EI24 mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EI24 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EI24 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of EI24 mRNA19320972
D003300CopperCopper results in decreased expression of EI24 mRNA16246896
D003300Copper[Copper results in increased activity of TP53 protein] which results in increased expression of EI24 mRNA16391388
D019327Copper SulfateCopper Sulfate results in decreased expression of EI24 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of EI24 mRNA20106945|2556210
D003630DaunorubicinDaunorubicin results in increased expression of EI24 mRNA17374387
D003907DexamethasoneDexamethasone results in increased expression of EI24 mRNA21041162
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EI24 mRNA27392435
D002945CisplatinCisplatin results in increased expression of EI24 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EI24 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EI24 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EI24 mRNA15545218|2104116
D004642EmodinEmodin results in increased expression of EI24 mRNA16045814
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EI24 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EI24 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EI24 mRNA23649840
D005047EtoposideEtoposide results in increased expression of EI24 mRNA17374387
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EI24 mRNA28329830
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]17317680
D005485FlutamideFlutamide results in decreased expression of EI24 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of EI24 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of EI24 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of EI24 mRNA24136188
C500810GW8510GW8510 results in increased expression of EI24 mRNA22242153
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EI24 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EI24 mRNA27392435
C410337K 7174K 7174 results in decreased expression of EI24 mRNA24086573
C038753leptomycin Bleptomycin B results in increased expression of EI24 mRNA20803015
C533894LG 100815LG 100815 results in increased expression of EI24 mRNA16951191
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EI24 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of EI24 mRNA15674843
D009151Mustard GasMustard Gas affects the expression of EI24 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EI24 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EI24 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of EI24 mRNA18651567
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of EI24 mRNA"16951191
D010862PilocarpinePilocarpine results in decreased expression of EI24 mRNA17971868
C006253pirinixic acidpirinixic acid results in increased expression of EI24 mRNA18301758|2381119
C045950propiconazolepropiconazole results in decreased expression of EI24 mRNA21278054
D011794QuercetinQuercetin results in increased expression of EI24 mRNA21632981
C059514resveratrolresveratrol results in increased expression of EI24 mRNA12569576|2634129
C059514resveratrolresveratrol results in increased expression of EI24 protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of EI24 mRNA20436886
C009166retinol acetateretinol acetate results in increased expression of EI24 mRNA16772331
D018038Sodium SeleniteSodium Selenite results in increased expression of EI24 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of EI24 mRNA17555576
D013654TaurineTaurine results in increased expression of EI24 mRNA16579726
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of EI24 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EI24 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EI24 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EI24 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EI24 mRNA12167310
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EI24 mRNA25613284
D014028Tobacco Smoke PollutionAcetylcysteine promotes the reaction [Tobacco Smoke Pollution results in increased expression of EI24 mRNA]16137721
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EI24 mRNA16137721
D014118Toxins, Biological"Toxins, Biological affects the expression of EI24 mRNA"19682533
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of EI24 mRNA]15363585
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EI24 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased methylation of EI24 gene29154799
D014635Valproic AcidValproic Acid affects the expression of EI24 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EI24 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EI24 mRNA23555832
D014800VitalliumVitallium analog results in decreased expression of EI24 mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016236macroautophagy-IBA21873635  
GO:0030308negative regulation of cell growth-IDA10594026  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23658154The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila. (2013 May 8)Devineni AVJ Neurosci
24921089Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. (2014 Jul 15)Sato TInt J Cancer