Gene: CIR1

9541
CIR
corepressor interacting with RBPJ, 1
protein-coding
2q31.1
Ensembl:ENSG00000138433 MIM:605228 Vega:OTTHUMG00000132338 UniprotKB:Q86X95
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.470e-1 (AD)  1.461e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD60.913
PSMC20.907
SNW10.905
IK0.905
SSB0.9
EIF3D0.9
CWC150.899
EMC40.896
TSG1010.895
ESD0.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.783
OR4F29-0.761
MTRNR2L6-0.176
MTRNR2L9-0.159
NKX6-1-0.159
C8orf74-0.157
HMHB1-0.156
BANF2-0.155
LYZL2-0.144
HTN3-0.142

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000393Air PollutantsAir Pollutants analog results in decreased expression of CIR1 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CIR1 mRNA"23195993
C006780bisphenol Abisphenol A affects the methylation of CIR1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of CIR1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CIR1 promoter22457795
D019327Copper SulfateCopper Sulfate results in increased expression of CIR1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CIR1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CIR1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CIR1 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CIR1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of CIR1 mRNA24793618
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CIR1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CIR1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CIR1 mRNA23649840
D009532NickelNickel results in increased expression of CIR1 mRNA23195993
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CIR1 mRNA27153767
D012999SomanSoman results in decreased expression of CIR1 mRNA19281266
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CIR1 mRNA28065790
D019772TopotecanTopotecan results in decreased expression of CIR1 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CIR1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of CIR1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CIR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CIR1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CIR1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003700DNA-binding transcription factor activity-TAS9874765  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-TAS18663143  
GO:0003714transcription corepressor activity-TAS9874765  
GO:0005515protein binding-IPI9874765  15652350  19409814  25416956  
GO:0019901protein kinase binding-IPI20873783  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0008380RNA splicing-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA9874765  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complexcolocalizes_withIDA9874765  
GO:0005634nucleus-IDA9874765  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosomecolocalizes_withIDA20873783  
GO:0016607nuclear speck-IDA-  
GO:0032991protein-containing complex-IDA20873783  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25144241A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. (2014 Nov)Kang HGJ Thorac Oncol