Gene: CHD1L

9557
ALC1|CHDL
chromodomain helicase DNA binding protein 1 like
protein-coding
1q21.1
Ensembl:ENSG00000131778 MIM:613039 Vega:OTTHUMG00000150271 UniprotKB:Q86WJ1
NG_052905.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.000e-1 (AD)  7.091e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11415275chr1:146715872CHD1LGene body2.609e-6Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IWS10.853
SNX10.851
ZNF1460.84
SLTM0.839
STAMBP0.837
OSBPL90.837
CDK5RAP20.831
FBXO70.827
CC2D1B0.821
FNTA0.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.635
OR4F5-0.591
EPPIN-0.212
KCNG1-0.207
USP17L4-0.195
SP8-0.183
CHRNA2-0.177
SHISA8-0.175
HTR3A-0.169
HCN4-0.152

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CHD1L mRNA"28903501
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHD1L mRNA19038236
D000082AcetaminophenAcetaminophen affects the expression of CHD1L mRNA17562736
D001280AtrazineAtrazine results in increased expression of CHD1L mRNA25929836
D001280AtrazineAtrazine results in decreased expression of CHD1L mRNA22378314
D001280AtrazineAtrazine results in increased expression of CHD1L mRNA27655631
C547126AZM551248AZM551248 results in increased expression of CHD1L mRNA22323515
D004958EstradiolEstradiol affects the expression of CHD1L mRNA18214933
C006780bisphenol Abisphenol A results in increased expression of CHD1L mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of CHD1L mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHD1L mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of CHD1L mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of CHD1L mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of CHD1L mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CHD1L mRNA20106945|2556210
C093628cyproconazolecyproconazole results in increased expression of CHD1L mRNA22334560
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CHD1L mRNA]27941970
C109476epoxiconazoleepoxiconazole results in increased expression of CHD1L mRNA22334560
D005485FlutamideFlutamide results in decreased expression of CHD1L mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHD1L mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CHD1L mRNA20655997|2364984
C410337K 7174K 7174 results in decreased expression of CHD1L mRNA24086573
C045463leflunomideleflunomide results in increased expression of CHD1L mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHD1L mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CHD1L mRNA25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CHD1L mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CHD1L mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CHD1L mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of CHD1L mRNA22714537
C025589ochratoxin Aochratoxin A results in decreased expression of CHD1L mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD1L mRNA25729387
D010098OxycodoneOxycodone results in increased expression of CHD1L mRNA23439660
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CHD1L protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CHD1L mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of CHD1L mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of CHD1L mRNA19482888
D010936Plant ExtractsPlant Extracts results in increased expression of CHD1L mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CHD1L mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of CHD1L mRNA23012394
C045950propiconazolepropiconazole results in increased expression of CHD1L mRNA21278054|2233456
D011794QuercetinQuercetin results in decreased expression of CHD1L mRNA21632981
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CHD1L mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of CHD1L mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHD1L mRNA15328365
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD1L mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CHD1L gene27618143
C012589trichostatin Atrichostatin A affects the expression of CHD1L mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of CHD1L mRNA24935251
D014303TrinitrotolueneTrinitrotoluene affects the expression of CHD1L mRNA21346803
D014415TunicamycinTunicamycin results in decreased expression of CHD1L mRNA22378314
D014520UrethaneUrethane results in decreased expression of CHD1L mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CHD1L mRNA25979313
D014750VincristineVincristine results in increased expression of CHD1L mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IDA19661379  
GO:0004003ATP-dependent DNA helicase activity-TAS19661379  
GO:0005515protein binding-IPI19661379  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IMP19661379  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-TAS19661379  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006338chromatin remodeling-IDA19661379  
GO:0006974cellular response to DNA damage stimulus-IDA19661379  
GO:0032508DNA duplex unwinding-IEA-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19661379  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact