Gene: BCAR1

9564
CAS|CAS1|CASS1|CRKAS|P130Cas
BCAR1, Cas family scaffold protein
protein-coding
16q23.1
Ensembl:ENSG00000050820 MIM:602941 Vega:OTTHUMG00000137604 UniprotKB:P56945
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.869e-1 (AD)  2.479e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF180.91
ZC3H180.898
U2AF20.893
ZNF2820.887
RBM100.883
SMG90.879
PHRF10.878
ZBTB170.877
KHSRP0.875
DNAJB20.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.577
HBD-0.329
VNN2-0.324
CPA3-0.321
IL18RAP-0.31
CEACAM3-0.304
CXCR2-0.303
P2RY14-0.299
MEI4-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of BCAR1 mRNA"26238599
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of BCAR1 mRNA"20702594
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of BCAR1 mRNA"20638727
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of BCAR1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of BCAR1 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to BCAR1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to BCAR1 protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of BCAR1 mRNA17562736
C016601afimoxifeneBCAR1 protein results in decreased susceptibility to afimoxifene18351453
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BCAR1 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of BCAR1 mRNA17023530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BCAR1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BCAR1 mRNA24449571
D001151ArsenicArsenic affects the methylation of BCAR1 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to BCAR1 protein]26598702
D001285AtropineAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]10537051
D001379AzathioprineAzathioprine results in increased expression of BCAR1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCAR1 mRNA22316170
C044887beta-methylcholinebeta-methylcholine affects the expression of BCAR1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of BCAR1 mRNA26364221
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of BCAR1 gene28505145
C006780bisphenol Abisphenol A results in increased expression of BCAR1 mRNA25181051
C472645blebbistatinblebbistatin results in decreased phosphorylation of BCAR1 protein18718759
C584509C646 compoundC646 compound results in decreased expression of BCAR1 mRNA26191083
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased phosphorylation of BCAR1 protein10741720
D000068579CelecoxibCelecoxib results in increased cleavage of and results in increased localization of BCAR1 protein16353145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR1 gene20938992
C074702chromium hexavalent ionBCAR1 protein affects the reaction [chromium hexavalent ion results in increased activity of MAPK8 protein]12902192
D002922CiguatoxinsCiguatoxins affects the expression of BCAR1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of BCAR1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of BCAR1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of BCAR1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of BCAR1 mRNA25562108
C093628cyproconazolecyproconazole results in decreased expression of BCAR1 mRNA26238599
D003976DiazinonDiazinon results in increased methylation of BCAR1 gene22964155
D002945CisplatinBCAR1 protein results in increased susceptibility to Cisplatin21291860|2172055
D002945CisplatinCisplatin results in increased expression of BCAR1 mRNA21151649
D005419FlavonoidsFlavonoids results in decreased expression of BCAR1 mRNA18035473
C053629fluoroaluminumfluoroaluminum results in increased phosphorylation of BCAR1 protein11792571
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR1 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of BCAR1 mRNA19167457
C070081fulvestrantBCAR1 affects the susceptibility to fulvestrant24169358
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of BCAR1 gene28505145
D005839GentamicinsGentamicins results in decreased expression of BCAR1 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BCAR1 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of BCAR1 mRNA26191083
C410337K 7174K 7174 results in increased expression of BCAR1 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BCAR1 mRNA"11578593
D008148LovastatinLovastatin results in increased cleavage of BCAR1 protein16367743
D008148LovastatinMevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]16367743
C032881lysophosphatidic acidlysophosphatidic acid results in increased phosphorylation of BCAR1 protein11792571
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAR1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BCAR1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BCAR1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BCAR1 mRNA26011545
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]16367743
C070571ML 7ML 7 results in decreased phosphorylation of BCAR1 protein18718759
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BCAR1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of BCAR1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of BCAR1 mRNA16166746
C012655nimesulidenimesulide results in decreased expression of BCAR1 mRNA24136188
D009569Nitric OxideNitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein]12714323
D009569Nitric OxideNitric Oxide results in decreased phosphorylation of BCAR1 protein12714323
D020030Nitric Oxide DonorsNitric Oxide Donors promotes the reaction [PTPN12 protein results in decreased phosphorylation of BCAR1 protein]12714323
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of BCAR1 mRNA22037397
C029341oxophenylarsineAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]10537051
C029341oxophenylarsineoxophenylarsine results in increased phosphorylation of BCAR1 protein10537051
C029341oxophenylarsine[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]10537051
C042743oxotremorine MAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]10537051
C042743oxotremorine M[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]10537051
C042743oxotremorine Moxotremorine M results in increased phosphorylation of BCAR1 protein10537051
C042743oxotremorine Mwortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein]10537051
D010126OzoneOzone results in increased expression of BCAR1 mRNA16330353
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of BCAR1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BCAR1 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of BCAR1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of BCAR1 mRNA22037397
D010656PhenylephrineABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]17615370
D010656PhenylephrineABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]17615370
D010656PhenylephrinePhenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]17615370
D010656PhenylephrinePhenylephrine results in increased phosphorylation of BCAR1 protein17615370
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCAR1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCAR1 mRNA19710929
D011189Potassium ChlorideABL1 protein affects the reaction [Potassium Chloride results in increased phosphorylation of BCAR1 protein]17615370
D011189Potassium ChloridePotassium Chloride results in increased phosphorylation of BCAR1 protein17615370
D011794QuercetinQuercetin results in increased expression of BCAR1 mRNA21632981
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased phosphorylation of BCAR1 protein11213483
C009166retinol acetateretinol acetate results in increased expression of BCAR1 mRNA16772331
D012715Sesame OilSesame Oil results in decreased expression of BCAR1 mRNA29191790
C025462sulindac sulfidesulindac sulfide results in decreased phosphorylation of BCAR1 protein10741720
D013629TamoxifenBCAR1 protein results in decreased susceptibility to Tamoxifen19330798
D013629TamoxifenTamoxifen promotes the reaction [BCAR1 protein mutant form results in decreased expression of BCL2 protein]19330798
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAR1 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of BCAR1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCAR1 mRNA19770486
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of BCAR1 protein20109541
D014212TretinoinTretinoin results in increased expression of BCAR1 mRNA16604517
C057693troglitazonetroglitazone results in decreased expression of BCAR1 mRNA28973697
D014520UrethaneUrethane results in increased expression of BCAR1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of BCAR1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of BCAR1 gene25560391
C009687wortmanninAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]10537051
C009687wortmannin[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]10537051
C009687wortmanninwortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein]10537051

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9285683  9360983  9407132  9418872  9748234  10339567  
10542110  10587647  10889023  11158326  11782456  12799422  
14657239  14688263  15866871  16105984  16245368  17038317  
17474147  18164686  19732724  20534451  21034468  22081014  
28007913  
GO:0017124SH3 domain binding-IEA-  
GO:0019901protein kinase binding-IPI8070403  8649368  9020138  9472046  10026197  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-TAS11607844  
GO:0007015actin filament organization-IDA16105984  
GO:0007155cell adhesion-IEA-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007173epidermal growth factor receptor signaling pathway-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-NAS10092204  
GO:0007229integrin-mediated signaling pathway-IDA8649368  
GO:0008283cell proliferation-TAS10639512  
GO:0008286insulin receptor signaling pathway-ISS-  
GO:0010595positive regulation of endothelial cell migration-IDA21245381  
GO:0016477cell migration-IBA21873635  
GO:0016477cell migration-IDA9425168  
GO:0030335positive regulation of cell migration-IDA9472046  
GO:0035729cellular response to hepatocyte growth factor stimulus-IMP21245381  
GO:0042981regulation of apoptotic process-TAS11607844  
GO:0048008platelet-derived growth factor receptor signaling pathway-ISS-  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP21245381  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048011neurotrophin TRK receptor signaling pathway-ISS-  
GO:0048012hepatocyte growth factor receptor signaling pathway-IMP21245381  
GO:0050851antigen receptor-mediated signaling pathway-IDA10587647  
GO:0050852T cell receptor signaling pathway-NAS9295052  
GO:0050853B cell receptor signaling pathway-IDA9020138  
GO:0051301cell division-NAS10675905  
GO:0060326cell chemotaxis-IMP21245381  
GO:0090527actin filament reorganization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IDA9472046  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA8070403  
GO:0005829cytosol-TAS-  
GO:0005886plasma membraneCOLOCALIZES_WITHIBA21873635  
GO:0005886plasma membranecolocalizes_withIDA21245381  
GO:0005925focal adhesion-IBA21873635  
GO:0005925focal adhesion-IDA21245381  
GO:0005925focal adhesion-ISS-  
GO:0015629actin cytoskeleton-IEA-  
GO:0030027lamellipodium-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-372708p130Cas linkage to MAPK signaling for integrinsTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-9006921Integrin signalingTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet