Gene: GABBR2

9568
EIEE59|GABABR2|GPR51|GPRC3B|HG20|HRIHFB2099|NDPLHS
gamma-aminobutyric acid type B receptor subunit 2
protein-coding
9q22.33
Ensembl:ENSG00000136928 MIM:607340 Vega:OTTHUMG00000020345 UniprotKB:O75899
NG_016426.1
PubMed|SNP Mapped
8   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.352e-1 (AD)  8.160e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2779582chr9:98524835 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2779581chr9:98524703 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2779576chr9:98522270 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs944760chr9:98521459 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2779569chr9:98518102 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2779556chr9:98503008 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2808560chr9:98499936 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs874278chr9:98487141 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENC10.975
SYT130.968
RGS40.967
KCNB10.966
GABRA10.962
RASGRF10.961
KIAA1549L0.96
SRRM40.959
SV2B0.958
NCALD0.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF5-0.578
ACAP1-0.572
REST-0.564
HEY2-0.551
WWTR1-0.543
TFPI2-0.541
RAI14-0.538
SNHG18-0.537
YES1-0.529
CNN2-0.526

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00181BaclofenSmall Molecule1134-47-0ApprovedTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB02530gamma-Aminobutyric acidSmall Molecule56-12-2Approved|InvestigationalTarget
DB05010SGS-742Small Molecule123690-78-8InvestigationalTarget
DB08891ArbaclofenSmall Molecule69308-37-8InvestigationalTarget
DB08892Arbaclofen PlacarbilSmall Molecule847353-30-4InvestigationalTarget
ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in decreased expression of GABBR2 mRNA"28591870
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
C4928471-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea"1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]"24482233
C4928471-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea"1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [PSMC5 protein binds to GABBR2 protein]"24482233
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GABBR2 mRNA"21277884
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GABBR2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GABBR2 mRNA"21277884
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C4386072,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of GABBR2 mRNA"20206263
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GABBR2 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GABBR2 mRNA]28655636
C0613883-aminopropylphosphinic acid"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
C0613883-aminopropylphosphinic acid3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]15627515
C0613883-aminopropylphosphinic acidCalcium promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GABBR2 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of GABBR2 mRNA28959563
D000447AldehydesAldehydes results in increased expression of GABBR2 mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GABBR2 mRNA28522335
D005680gamma-Aminobutyric Acid1-(3-chlorophenyl)piperazine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D005680gamma-Aminobutyric Acid"2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]"15627515
D005680gamma-Aminobutyric Acid"3,4-Methylenedioxyamphetamine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]"21729720
D005680gamma-Aminobutyric AcidAmphetamine promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D005680gamma-Aminobutyric AcidCalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
D005680gamma-Aminobutyric AcidCalcium promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D005680gamma-Aminobutyric AcidCGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D005680gamma-Aminobutyric Acid"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric Acid"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]15627515
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]11125035
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]21729720
D005680gamma-Aminobutyric AcidMethamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D005680gamma-Aminobutyric Acidmethylone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D005680gamma-Aminobutyric Acid"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GABBR2 mRNA16483693
D000661AmphetamineAmphetamine promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D001151ArsenicArsenic affects the methylation of GABBR2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of GABBR2 mRNA15761015
D001418BaclofenBaclofen binds to GABBR2 protein17496723
D001418BaclofenGABBR2 results in increased susceptibility to Baclofen20138995
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction and affects the localization of [PSMC5 protein binds to GABBR2 protein]24482233
D004958EstradiolEstradiol affects the expression of GABBR2 mRNA14699072
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GABBR2 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of GABBR2 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of GABBR2 mRNA19619570|2118537
D004958EstradiolRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of GABBR2 mRNA]21185374
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GABBR2 mRNA19833106
C006780bisphenol Abisphenol A results in decreased expression of GABBR2 mRNA24284790|2859187
C006780bisphenol Abisphenol A results in increased methylation of GABBR2 gene28505145
C492482bisphenol Bbisphenol B results in decreased expression of GABBR2 mRNA28591870
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of GABBR2 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of GABBR2 mRNA26079696
D002118CalciumCalcium promotes the reaction [3-aminopropylphosphinic acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D002118CalciumCalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
D002118CalciumCalcium promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
D002220CarbamazepineCarbamazepine affects the expression of GABBR2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GABBR2 mRNA19784758
C085075CGP 55845ACalcium promotes the reaction [CGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]15627515
C085075CGP 55845ACGP 55845A binds to and results in decreased activity of [GABBR1 protein binds to GABBR2 protein]15627515
C085075CGP 55845ACGP 55845A inhibits the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]15627515
C104980CGP 71872CGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]11125035
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GABBR2 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GABBR220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GABBR2 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of GABBR2 mRNA19320972
D003042CocaineCocaine results in decreased phosphorylation of GABBR2 protein12716959
D003634DDTDDT results in decreased expression of GABBR2 mRNA19797855
D003976DiazinonDiazinon results in increased methylation of GABBR2 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GABBR2 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of GABBR2 mRNA25016146
D004533Egtazic Acid"Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C118739entinostatentinostat results in increased expression of GABBR2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GABBR2 mRNA23649840
D005275Fendiline"Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GABBR2 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GABBR220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GABBR2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of GABBR2 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of GABBR2 mRNA23649840
C040029gabapentinCGP 71872 inhibits the reaction [gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]]11125035
C040029gabapentingabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]11125035
C040029gabapentin[gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
D006582HexachloropheneHexachlorophene affects the expression of GABBR2 mRNA29301063
D007501Iron[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA18771689
D007501Iron[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein18771689
D007501IronIron deficiency results in decreased expression of GABBR2 mRNA18771689
D007501IronIron deficiency results in decreased expression of GABBR2 protein18771689
D007854LeadLead affects the expression of GABBR2 mRNA28903495
C025340manganese chloride[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA18771689
C025340manganese chloride[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein18771689
C025340manganese chloridemanganese chloride results in decreased expression of GABBR2 mRNA18771689
D008694MethamphetamineMethamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GABBR2 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GABBR220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GABBR2 gene20938992
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine affects the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]"21729720
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GABBR2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GABBR2 mRNA23649840
C400939methylonemethylone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]]21729720
D008743Methyl ParathionMethyl Parathion results in increased expression of GABBR2 mRNA19784758
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of GABBR2 mRNA22401849
C523799MRK 003MRK 003 results in decreased expression of GABBR2 mRNA21169257
C025589ochratoxin Aochratoxin A results in increased expression of GABBR2 mRNA18417182
D010100OxygenOxygen deficiency results in decreased expression of GABBR2 mRNA26516004
D010278ParathionParathion results in increased expression of GABBR2 mRNA19784758
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GABBR2 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of GABBR2 mRNA28655636
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GABBR2 mRNA"21277884
C410127PCB 180PCB 180 results in increased expression of GABBR2 mRNA23829299
C046012pentanalpentanal results in increased expression of GABBR2 mRNA26079696
D010852Picrotoxin"1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]"24482233
D010852PicrotoxinPicrotoxin results in decreased expression of and affects the localization of GABBR2 protein24482233
C006253pirinixic acidpirinixic acid results in decreased expression of GABBR2 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GABBR2 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GABBR2 mRNA19833106
C005556propionaldehydepropionaldehyde results in increased expression of GABBR2 mRNA26079696
C012526quercitrinquercitrin results in increased expression of GABBR2 mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of GABBR2 mRNA]21185374
C017947sodium arsenitesodium arsenite affects the methylation of GABBR2 gene28589171
D012989Soil PollutantsSoil Pollutants results in increased expression of GABBR2 mRNA19695345
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GABBR2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GABBR2 mRNA16704738|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GABBR2 mRNA26290441
D019284ThapsigarginThapsigargin affects the localization of GABBR2 protein24668805
C402769tipifarnibtipifarnib results in increased expression of GABBR2 mRNA16403772
D014212TretinoinTretinoin results in increased expression of GABBR2 mRNA21934132|2383079
D014268Trifluoperazine"Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]"15627515
C057693troglitazonetroglitazone results in decreased expression of GABBR2 mRNA19140230
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GABBR2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GABBR2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GABBR2 mRNA23179753|2493525
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GABBR2 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of GABBR2 mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004965G-protein coupled GABA receptor activitycontributes_toIDA9872316  
GO:0005515protein binding-IPI16724110  24305054  24658140  
GO:0046982protein heterodimerization activity-IPI15304491  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007194negative regulation of adenylate cyclase activity-TAS10328880  
GO:0007214gamma-aminobutyric acid signaling pathway-IDA9872316  
GO:0007268chemical synaptic transmission-TAS9872316  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA9872316  15304491  
GO:0030054cell junction-IEA-  
GO:0038039G-protein coupled receptor heterodimeric complex-IPI9872316  
GO:0043005neuron projection-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:1902710GABA receptor complex-IDA15304491  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25191505GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. (2014 Aug)Terranova CClin Psychopharmacol Neurosci
23822588GABA receptors, alcohol dependence and criminal behavior. (2013 Sep)Terranova CJ Forensic Sci
18482426Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (2008 Jun)Agrawal AAddiction
19763258Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. (2009 Sep 18)Li MDPLoS One
22309839Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)Wei JAddict Behav
26451072Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. (2012)Jugessur ANor Epidemiol