Gene: GTF2IRD1

9569
BEN|CREAM1|GTF3|MUSTRD1|RBAP2|WBS|WBSCR11|WBSCR12|hMusTRD1alpha1
GTF2I repeat domain containing 1
protein-coding
7q11.23
Ensembl:ENSG00000006704 MIM:604318 Vega:OTTHUMG00000023782 UniprotKB:Q9UHL9
NG_027954.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.429e-1 (AD)  8.339e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs34158545chr7:74586566 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13246861chr7:74586525 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13244286chr7:74586350 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MLXIP0.856
QSOX20.84
SYVN10.838
PCID20.838
SCAF40.838
PLEKHM10.837
ZDHHC180.837
MARK30.836
UPF10.834
ZSWIM80.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.474
DNASE1L3-0.291
KLRB1-0.289
KLRC2-0.288
ECM2-0.284
CETP-0.279
RERGL-0.278
KLRF1-0.274
IFNG-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GTF2IRD1 mRNA"19162173
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GTF2IRD1 mRNA"19167446
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of GTF2IRD1 protein22434383
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GTF2IRD1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GTF2IRD1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GTF2IRD1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GTF2IRD1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GTF2IRD1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GTF2IRD1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTF2IRD1 mRNA"19150397|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of GTF2IRD1 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of GTF2IRD1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of GTF2IRD1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of GTF2IRD1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GTF2IRD1 mRNA15336504
D002994ClofibrateClofibrate results in increased expression of GTF2IRD1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of GTF2IRD1 mRNA19376846
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GTF2IRD1 mRNA"19167446
D003471CuprizoneCuprizone results in increased expression of GTF2IRD1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of GTF2IRD1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of GTF2IRD1 mRNA20106945|2556210
D015946Ethylene DibromideEthylene Dibromide results in decreased expression of GTF2IRD1 protein22434383
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GTF2IRD1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of GTF2IRD1 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GTF2IRD1 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTF2IRD1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of GTF2IRD1 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of GTF2IRD1 mRNA19167457
D017313FenretinideFenretinide results in increased expression of GTF2IRD1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GTF2IRD1 mRNA24796395
C410337K 7174K 7174 results in increased expression of GTF2IRD1 mRNA24086573
D007649KetamineKetamine results in increased expression of GTF2IRD1 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GTF2IRD1 mRNA"24972896
C002950methylformamidemethylformamide affects the expression of GTF2IRD1 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of GTF2IRD1 mRNA17040096
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GTF2IRD1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GTF2IRD1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of GTF2IRD1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GTF2IRD1 mRNA25729387
D010634PhenobarbitalPhenobarbital results in increased expression of GTF2IRD1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GTF2IRD1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of GTF2IRD1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of GTF2IRD1 mRNA18301758|2381119
D010894PiroxicamPiroxicam results in decreased expression of GTF2IRD1 mRNA21858171
D059808PolyphenolsPolyphenols results in decreased expression of GTF2IRD1 mRNA16293270
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GTF2IRD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GTF2IRD1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GTF2IRD1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of GTF2IRD1 mRNA18037150
D012834SilverSilver results in decreased expression of GTF2IRD1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in increased expression of GTF2IRD1 mRNA27862939
D013629TamoxifenTamoxifen affects the expression of GTF2IRD1 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GTF2IRD1 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTF2IRD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GTF2IRD1 mRNA21889950
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GTF2IRD1 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GTF2IRD1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of GTF2IRD1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GTF2IRD1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of GTF2IRD1 mRNA28973697
D014520UrethaneUrethane results in decreased expression of GTF2IRD1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GTF2IRD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GTF2IRD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GTF2IRD1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of GTF2IRD1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of GTF2IRD1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of GTF2IRD1 mRNA15901671
D014810Vitamin EVitamin E results in decreased expression of GTF2IRD1 mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of GTF2IRD1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003700DNA-binding transcription factor activity-NAS10575229  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-NAS9774679  
GO:0005515protein binding-IPI26275350  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS10575229  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0014886transition between slow and fast fiber-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS11438732  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa03022Basal transcription factors
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal