Gene: NR1D1

9572
EAR1|REVERBA|REVERBalpha|THRA1|THRAL|ear-1|hRev
nuclear receptor subfamily 1 group D member 1
protein-coding
17q21.1
Ensembl:ENSG00000126368 MIM:602408 Vega:OTTHUMG00000133327 UniprotKB:P20393
NG_033084.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.593e-1 (AD)  3.350e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL210.781
RERE0.748
PDXK0.743
USP20.74
REPIN10.74
TSHZ10.737
TMEM184B0.737
MBOAT70.732
ATN10.729
GPR1370.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.535
TFPI2-0.385
CD3G-0.379
CD48-0.35
GZMA-0.35
CETP-0.345
CD3D-0.344
KLRF1-0.344
SH2D1A-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of NR1D1 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR1D1 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NR1D1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NR1D1 mRNA"27291303
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of NR1D1 mRNA22923002
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NR1D1 mRNA"28433925
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of NR1D1 mRNA25088246
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of NR1D1 mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of NR1D1 mRNA28522335
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of NR1D1 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of NR1D1 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of NR1D1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D1 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of NR1D1 mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of NR1D1 mRNA22197712|2860676
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NR1D1 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NR1D1 mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of NR1D1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR1D1 mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of NR1D1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of NR1D1 mRNA23912714
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NR1D1 mRNA"18687144
D001507BeclomethasoneBeclomethasone results in increased expression of NR1D1 mRNA23656298
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NR1D1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NR1D1 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NR1D1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NR1D1 mRNA22610609
D004958EstradiolEstradiol affects the expression of NR1D1 mRNA18214933
D004958EstradiolEstradiol results in decreased expression of NR1D1 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of NR1D1 mRNA26364221
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NR1D1 mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of NR1D1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of NR1D1 mRNA18958704
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NR1D1 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride affects the expression of NR1D1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NR1D1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NR1D1 mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of NR1D1 mRNA18500788
D002737ChloropreneChloroprene results in decreased expression of NR1D1 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of NR1D1 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of NR1D1 mRNA25064622
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D1 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D1 mRNA]17585979
D003033Coal TarCoal Tar results in increased expression of NR1D1 mRNA27858113
D003300CopperCopper results in decreased expression of NR1D1 mRNA26293553
D016572CyclosporineCyclosporine affects the expression of NR1D1 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of NR1D1 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of NR1D1 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NR1D1 mRNA23640034
C007262deoxynivalenoldeoxynivalenol results in increased expression of NR1D1 mRNA22846391
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NR1D1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of NR1D1 mRNA17075855
D003907Dexamethasone[Dexamethasone co-treated with INS1 protein] results in increased expression of NR1D1 mRNA9543393
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NR1D1 mRNA28962523
C000944dicrotophosdicrotophos results in increased expression of NR1D1 mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of NR1D1 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of NR1D1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of NR1D1 mRNA23537522
D004041Dietary FatsDietary Fats results in increased expression of NR1D1 protein23537522
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of NR1D1 mRNA]23537522
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of NR1D1 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NR1D1 mRNA19245819
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NR1D1 mRNA"28433925
C014476diethyl maleatediethyl maleate results in decreased expression of NR1D1 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NR1D1 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NR1D1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of NR1D1 mRNA21551480
D004237DiuronDiuron results in increased expression of NR1D1 mRNA25152437
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of NR1D1 mRNA25187966
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of NR1D1 mRNA24534155
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NR1D1 mRNA25064622
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of NR1D1 gene16495775
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR1D1 mRNA28329830
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of NR1D1 mRNA24657277
C069837fullerene C60fullerene C60 results in increased expression of NR1D1 mRNA19167457
C039281furanfuran results in increased methylation of NR1D1 gene22079235
D019833GenisteinGenistein results in decreased expression of NR1D1 mRNA16169203
D006220HaloperidolHaloperidol results in increased expression of NR1D1 mRNA11564422
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of NR1D1 mRNA23153324
D017313FenretinideFenretinide results in decreased expression of NR1D1 mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid results in decreased expression of NR1D1 mRNA17075855
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NR1D1 mRNA26846883
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of NR1D1 mRNA19376150
C016517indole-3-carbinolindole-3-carbinol affects the expression of NR1D1 mRNA21396975
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of NR1D1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NR1D1 mRNA23086925|2743299
D007649KetamineKetamine results in increased expression of NR1D1 mRNA20080153
D007854LeadLead affects the expression of NR1D1 mRNA28903495
C045463leflunomideleflunomide results in increased expression of NR1D1 mRNA28988120
D008094LithiumNR1D1 gene polymorphism affects the susceptibility to Lithium20348464
D047311LuteolinLuteolin results in decreased expression of NR1D1 mRNA19397994
C025340manganese chloridemanganese chloride results in increased expression of NR1D1 mRNA28511934
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of NR1D1 mRNA24657277
D008752Methylene ChlorideMethylene Chloride results in increased expression of NR1D1 mRNA28392392
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NR1D1 mRNA"20188158
C059539midostaurinmidostaurin results in decreased expression of NR1D1 mRNA20980353
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NR1D1 mRNA"29244179
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of NR1D1 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NR1D1 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of NR1D1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NR1D1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NR1D1 mRNA"25554681|2562005
D009281NaphthalenesNaphthalenes results in decreased expression of NR1D1 protein17337753
D019829NevirapineNevirapine metabolite results in decreased expression of NR1D1 mRNA23947594
C028007nickel monoxidenickel monoxide results in increased expression of NR1D1 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of NR1D1 mRNA19716841
D000069463Olive OilOlive Oil analog affects the expression of NR1D1 mRNA17349074
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of NR1D1 mRNA24888373
D009966OrphenadrineOrphenadrine affects the expression of NR1D1 mRNA23665939
C005290oxybenzoneoxybenzone results in decreased expression of NR1D1 mRNA22721600
D010100OxygenOxygen deficiency results in increased expression of NR1D1 mRNA16373842
D010100OxygenSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NR1D1 mRNA]16373842
D010126OzoneOzone results in decreased expression of NR1D1 mRNA12763052
D010126OzoneTTPA protein affects the reaction [Ozone results in decreased expression of NR1D1 mRNA]19555225
D000073878Palm OilPalm Oil results in decreased expression of NR1D1 mRNA18042831
D010269ParaquatParaquat affects the expression of NR1D1 mRNA25064622
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NR1D1 mRNA19162173
D010578PetroleumPetroleum results in decreased expression of NR1D1 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of NR1D1 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NR1D1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of NR1D1 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of NR1D1 mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of NR1D1 mRNA18301758
D010938Plant OilsPlant Oils results in increased expression of NR1D1 mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of NR1D1 mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in increased expression of NR1D1 mRNA23608068
D011239PrednisolonePrednisolone results in decreased expression of NR1D1 mRNA16269518
D011239PrednisolonePrednisolone results in decreased expression of NR1D1 mRNA16269518
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NR1D1 mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NR1D1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of NR1D1 mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of NR1D1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of NR1D1 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of NR1D1 protein17337753
D011794QuercetinQuercetin results in increased expression of NR1D1 mRNA18095365
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA19059307
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of NR1D1 mRNA]23537522
C541923sandostatinLARsandostatinLAR results in increased expression of NR1D1 mRNA17210224
C459379SCH 351591SCH 351591 results in increased expression of NR1D1 mRNA20585143
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of NR1D1 mRNA17540011
C009250sevofluranesevoflurane affects the expression of NR1D1 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NR1D1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NR1D1 mRNA22300531
D012822Silicon DioxideSilicon Dioxide affects the expression of NR1D1 mRNA22431001
D019821SimvastatinSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NR1D1 mRNA]16373842
C009277sodium arsenatesodium arsenate results in decreased expression of NR1D1 mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of NR1D1 mRNA27859739
D053260SootSoot affects the expression of NR1D1 mRNA26551751
D013311StreptozocinStreptozocin results in decreased expression of NR1D1 mRNA25905778
D020058StyreneStyrene results in increased expression of NR1D1 mRNA28951217
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of NR1D1 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR1D1 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NR1D1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NR1D1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR1D1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR1D1 mRNA19933214|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR1D1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR1D1 mRNA21215274
D013752TetracyclineTetracycline affects the expression of NR1D1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of NR1D1 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of NR1D1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of NR1D1 mRNA23409001|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NR1D1 mRNA20133372
D014212TretinoinTretinoin results in increased expression of NR1D1 mRNA17075855
D014241TrichloroethyleneTrichloroethylene results in increased expression of NR1D1 mRNA28973375
C012589trichostatin Atrichostatin A results in increased expression of NR1D1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NR1D1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NR1D1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NR1D1 mRNA28973697
C022884undecaneundecane results in decreased expression of NR1D1 protein17337753
D014520UrethaneUrethane results in decreased expression of NR1D1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NR1D1 mRNA25064622
D014635Valproic AcidValproic Acid results in decreased methylation of NR1D1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NR1D1 mRNA17963808|2922923
D014635Valproic AcidValproic Acid results in increased expression of NR1D1 mRNA23665938
D014635Valproic AcidValproic Acid results in increased expression of NR1D1 mRNA15901671
D014640VancomycinVancomycin results in increased expression of NR1D1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NR1D1 gene25560391
C025643vinclozolinvinclozolin affects the expression of NR1D1 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of NR1D1 mRNA"25208076
D019287Zinc SulfateZinc Sulfate results in decreased expression of NR1D1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA19955433  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15761026  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IMP8622974  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA8622974  
GO:0001222transcription corepressor binding-IDA15761026  
GO:0001222transcription corepressor binding-IMP18006707  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003714transcription corepressor activity-TAS8622974  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-TAS8622974  
GO:0005515protein binding-IPI17892483  20534529  20581824  21874017  22170608  23398316  
24311788  24737000  26871637  
GO:0008134transcription factor binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO:0020037heme binding-IDA18006707  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA18511497  
GO:0070888E-box binding-IEA-  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA8622974  19955433  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18511497  
GO:0005978glycogen biosynthetic process-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007623circadian rhythm-TAS-  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0010498proteasomal protein catabolic process-ISS-  
GO:0010871negative regulation of receptor biosynthetic process-IMP18511497  
GO:0019216regulation of lipid metabolic process-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0033993response to lipid-IBA21873635  
GO:0034144negative regulation of toll-like receptor 4 signaling pathway-IMP18511497  
GO:0035947regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter-IMP18006707  
GO:0042632cholesterol homeostasisNOTIDA18511497  
GO:0042632cholesterol homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-IBA21873635  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0044321response to leptin-IBA21873635  
GO:0044321response to leptin-ISS-  
GO:0045598regulation of fat cell differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA15761026  20070857  23398316  
GO:0045892negative regulation of transcription, DNA-templated-IMP18006707  21628546  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0060086circadian temperature homeostasis-ISS-  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0061469regulation of type B pancreatic cell proliferation-ISS-  
GO:0070859positive regulation of bile acid biosynthetic process-ISS-  
GO:0071222cellular response to lipopolysaccharide-IMP18511497  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA18511497  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0016604nuclear body-IDA-  
GO:0030425dendrite-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-1368071NR1D1 (REV-ERBA) represses gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
26446021Possible involvement of the circadian pathway in alcohol use disorder in a South African adolescent cohort. (2016 Feb)Dalvie SMetab Brain Dis