Gene: SPAG6

9576
CT141|Repro-SA-1|pf16
sperm associated antigen 6
protein-coding
10p12.2
Ensembl:ENSG00000077327 MIM:605730 Vega:OTTHUMG00000017808 UniprotKB:O75602
NC_000010.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.801e-2 (AD)  2.952e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11864574chr10:22635028SPAG61.100e-10Maternal smoking in pregnancy27040690
cg11864574chr10:22635028SPAG61.650e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL12A10.781
AHI10.765
ABCA50.761
SLC44A50.753
CAPS20.753
TASP10.749
STAMBPL10.744
CDC70.744
OSBPL100.74
GLMN0.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.513
RHOD-0.496
SIX5-0.474
ACOX2-0.474
HVCN1-0.463
NKAIN3-0.459
SYDE1-0.458
LRP5-0.451
AKR1C3-0.45
SOD3-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SPAG6 gene27153756
D001241AspirinAspirin results in increased expression of SPAG6 mRNA11906190
D001280AtrazineAtrazine results in decreased expression of SPAG6 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SPAG6 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPAG6 mRNA17879257
C006780bisphenol Abisphenol A affects the expression of SPAG6 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of SPAG6 mRNA26577399
C118739entinostatentinostat results in increased expression of SPAG6 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SPAG6 mRNA17555576
C004312glycidolglycidol results in decreased expression of SPAG6 mRNA24915197
D007213IndomethacinIndomethacin results in increased expression of SPAG6 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SPAG6 mRNA25613284
C042720mercuric bromidemercuric bromide results in decreased expression of SPAG6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SPAG6 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SPAG6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPAG6 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SPAG6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SPAG6 mRNA"25554681
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPAG6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SPAG6 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of SPAG6 mRNA20813756
D012839SimazineSimazine results in decreased expression of SPAG6 mRNA22984576
D012969Sodium FluorideSodium Fluoride results in increased expression of SPAG6 protein28918527
D013629TamoxifenTamoxifen affects the expression of SPAG6 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPAG6 mRNA18495758
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SPAG6 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SPAG6 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of SPAG6 mRNA20530235
D014635Valproic AcidValproic Acid affects the expression of SPAG6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SPAG6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SPAG6 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SPAG6 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SPAG6 mRNA22615374
C111237vorinostatvorinostat results in increased expression of SPAG6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007286spermatid development-TAS10493827  
GO:0030030cell projection organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005874microtubule-IEA-  
GO:0005930axoneme-TAS10493827  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0031514motile cilium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16809635Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. (2006 Dec)Lonergan KMAm J Respir Cell Mol Biol