Gene info: ID 958

Gene: CD40

GENE ID: 958

Synonyms: Bp50|CDW40|TNFRSF5|p50

Description: CD40 molecule

Gene type: protein-coding

Location: 20q13.12

dbXrefs: Ensembl:ENSG00000101017 MIM:109535 Vega:OTTHUMG00000033053 UniprotKB:P25942

RefSeq: NG_007279.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 64

Sherlock p-value : 8.533e-1 (AD) 4.084e-1 (ND) (Frontal_Cortex)

Pascal p-value : 2.666e-1 (AD) 1.262e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LTBR	0.862
MYD88	0.848
MOB3C	0.84
SLC15A3	0.832
PRICKLE3	0.83
MSN	0.827
CLIC1	0.826
NXN	0.823
TEAD2	0.823
TGFB1	0.822

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC7A4	-0.577
ABCC12	-0.567
KCNB2	-0.554
PPEF1	-0.553
SMIM18	-0.55
MYADML2	-0.546
MARCH4	-0.544
GPR61	-0.542
PTPRR	-0.541
XKR4	-0.536

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06360	Lucatumumab	Small Molecule	903512-50-5	Investigational	Target
DB12589	Dacetuzumab	BiotechDrug	880486-59-9	Investigational	Target

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of CD40 mRNA	19435785
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]"	16879495
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of CD40 mRNA"	19114083
C038293	2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine	"[2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased expression of CD40 protein"	16299289
C038293	2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine	"[2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine co-treated with FK 565] results in increased expression of CD40 protein"	16299289
C038293	2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine	"2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine results in increased expression of CD40 protein"	16299289
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CD40 mRNA"	21346803
C003898	2-anisidine	2-anisidine affects the expression of CD40 mRNA	28089782
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]	24192212
C457499	2-chloro-5-nitrobenzanilide	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]	24192212
C457499	2-chloro-5-nitrobenzanilide	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]	24192212
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	25843059
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid results in decreased expression of CD40 mRNA"	25843059
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CD40 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
C408690	4-cresol sulfate	4-cresol sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	26784855
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]"	16879495
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA	19191707
C012358	4-hydroxycyclophosphamide	[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA	25833159
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
D000119	Acetylmuramyl-Alanyl-Isoglutamine	"[2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased expression of CD40 protein"	16299289
D000119	Acetylmuramyl-Alanyl-Isoglutamine	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD40 protein	16299289
D000119	Acetylmuramyl-Alanyl-Isoglutamine	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD40 protein	16299289
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD40 protein	16299289
D000276	Adjuvants, Immunologic	"Adjuvants, Immunologic results in increased expression of CD40 protein"	11160013
C016601	afimoxifene	[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA	25833159
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CD40 mRNA	19770486
D000447	Aldehydes	Aldehydes results in increased expression of CD40 mRNA	25014914
D013196	Dihydrotestosterone	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]]	16317058
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	16317058
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]	16317058
C054284	alpha-fluoromethylhistamine	[alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein	11306145
D000536	Aluminum Hydroxide	Aluminum Hydroxide results in increased expression of CD40 protein	11160013
D015761	4-Aminopyridine	4-Aminopyridine results in increased expression of CD40 mRNA	24378259
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CD40 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD40 mRNA	24449571
D047310	Apigenin	Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D016718	Arachidonic Acid	Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	15684433
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in increased expression of CD40 mRNA	19962721
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in increased expression of CD40 protein	19962721
D001151	Arsenic	Arsenic results in decreased methylation of CD40 gene	27838757
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CD40 protein	27430728
C015001	arsenite	arsenite results in increased expression of CD40 protein	28499612
D001194	Asbestos	Asbestos results in increased expression of CD40 mRNA	22398240
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CD40 mRNA	16443354
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of CD40 protein	16387846
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [IFNG results in increased expression of CD40 protein]	17507688
D001285	Atropine	Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]	16879495
C416282	BAY 11-7085	BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD40 protein]	17636246
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CD40 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD40 mRNA	21569818\|2222880
D004958	Estradiol	Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	28811679
D004958	Estradiol	[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD40 protein	28811679
D004958	Estradiol	Estradiol affects the expression of CD40 protein	15964915
D047071	beta-Glucans	beta-Glucans results in increased expression of CD40 protein	17572156
D001624	Betamethasone Valerate	Betamethasone Valerate results in decreased expression of CD40 protein	15940147
C053541	bicalutamide	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]]	16317058
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CD40 mRNA	28628672
C006780	bisphenol A	[bisphenol A results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD40 protein	28811679
C006780	bisphenol A	bisphenol A affects the expression of CD40 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of CD40 mRNA	26079696
D000001	Calcimycin	Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D000001	Calcimycin	fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D000001	Calcimycin	Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D000001	Calcimycin	Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]	16601352
D000001	Calcimycin	Quercetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D002217	Carbachol	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]"	16879495
D002217	Carbachol	"4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]"	16879495
D002217	Carbachol	Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]	16879495
D002217	Carbachol	Carbachol results in increased expression of CD40 protein	16879495
D002217	Carbachol	Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]	16879495
D002737	Chloroprene	Chloroprene results in decreased expression of CD40 mRNA	23125180
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of CD40 protein"	21574786
D002791	Cholesterol, Dietary	"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of CD40 protein]"	21574786
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD40 mRNA	20938992
D002990	Clobetasol	Clobetasol results in decreased expression of CD40 protein	15086553
D002994	Clofibrate	Clofibrate results in decreased expression of CD40 mRNA	16081524
C423449	CpG ODN 1826	[bisphenol A results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD40 protein	28811679
C423449	CpG ODN 1826	[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD40 protein	28811679
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein	27430728
D003474	Curcumin	Curcumin results in decreased expression of CD40 mRNA	16101141
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of CD40 mRNA	21041162
C004742	daidzein	daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21945492
C014347	decitabine	decitabine results in increased expression of CD40 protein	19401350
D013759	Dronabinol	Dronabinol results in increased expression of CD40 mRNA	18163980
D003703	Demecolcine	Demecolcine results in increased expression of CD40 mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of CD40 mRNA	22968694
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CD40 mRNA	28628672
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22185406
D003907	Dexamethasone	Dexamethasone results in increased expression of CD40 mRNA	21041162\|2218540
D003976	Diazinon	Diazinon results in increased expression of CD40 protein	28119078
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CD40 mRNA	17361019\|2126653
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CD40 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CD40 mRNA	26546572
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CD40 mRNA	28412506
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CD40 mRNA	24535843
D002117	Calcitriol	Calcitriol results in decreased expression of CD40 protein	10679076
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CD40 mRNA"	27840820
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD40 protein	17636246\|2174278
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene inhibits the reaction [TNF protein results in increased expression of CD40 protein]	17636246
D004317	Doxorubicin	Doxorubicin results in decreased expression of CD40 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides promotes the reaction [Doxorubicin results in decreased expression of CD40 mRNA]	27181935
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of CD40 protein"	15894585
D004365	Drugs, Chinese Herbal	"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD40 protein]"	15894585
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	15684433
C118739	entinostat	entinostat results in increased expression of CD40 mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CD40 mRNA	24534155
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) affects the expression of CD40 protein"	15964915
D000431	Ethanol	Ethanol results in decreased expression of CD40 protein	21574786
C496966	Eudragit RSPO	Eudragit RSPO results in decreased expression of CD40 mRNA	22119964
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	15684433
D011345	Fenofibrate	Fenofibrate results in decreased expression of CD40 mRNA	20520642
C017875	fisetin	fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
C039537	FK 565	"[2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine co-treated with FK 565] results in increased expression of CD40 protein"	16299289
C039537	FK 565	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD40 protein	16299289
C039537	FK 565	[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD40 protein	16299289
C039537	FK 565	FK 565 results in increased expression of CD40 protein	16299289
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in increased expression of CD40 mRNA	19962721
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in increased expression of CD40 protein	19962721
D005472	Fluorouracil	CD40 results in decreased susceptibility to Fluorouracil	20188757
D005472	Fluorouracil	Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]	15611226
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD40 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of CD40 mRNA	23649840
D062610	Fungal Polysaccharides	Fungal Polysaccharides promotes the reaction [Doxorubicin results in decreased expression of CD40 mRNA]	27181935
C039281	furan	furan results in increased expression of CD40 mRNA	22079235\|2738771
D005665	Furosemide	Furosemide affects the expression of CD40 mRNA	17497460
C546771	gardiquimod	gardiquimod results in increased expression of CD40 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD40 mRNA]	28003376
C056507	gemcitabine	gemcitabine results in decreased expression of CD40 mRNA	17039268
C056507	gemcitabine	gemcitabine results in decreased expression of CD40 protein	20531411
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22687549
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]	17507688
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]	17507688
C102521	GGTI 298	GGTI 298 inhibits the reaction [IFNG results in increased expression of CD40 mRNA]	17507688
C102521	GGTI 298	GGTI 298 inhibits the reaction [IFNG results in increased expression of CD40 protein]	17507688
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA	28433809
D012971	Gold Sodium Thiosulfate	Gold Sodium Thiosulfate results in increased expression of CD40 protein	25458486
C001329	helenalin	"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD40 protein]"	15894585
C001329	helenalin	helenalin inhibits the reaction [Polysaccharides results in increased expression of CD40 protein]	15894585
D006632	Histamine	[alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein	11306145
D006632	Histamine	[tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein	11306145
D006632	Histamine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein	11306145
D017313	Fenretinide	Fenretinide results in increased expression of CD40 mRNA	28973697
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of CD40 protein	15086553
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]	24192212
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]	24192212
C085278	hydroxysafflor yellow A	hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein]	24192212
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21948866
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in decreased expression of CD40 protein	21948866
C474021	indirubin-3'-monoxime	[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein	21948866
C016517	indole-3-carbinol	indole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of CD40 protein	21948866
C016517	indole-3-carbinol	[Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of CD40 protein	21948866
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CD40 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CD40 mRNA	28628672
D007530	Isoflurane	Isoflurane results in decreased expression of CD40 mRNA	16978161
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CD40 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CD40 protein	27169980
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CD40 mRNA	23828858
C008261	lead acetate	[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD40 protein	17512567
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of CD40 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD40 protein"	17630318\|2567329
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD40 protein"	23624183
D008070	Lipopolysaccharides	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD40 protein	16299289
D008070	Lipopolysaccharides	Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	15684433
D008070	Lipopolysaccharides	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]]	16317058
D008070	Lipopolysaccharides	Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	16317058
D008070	Lipopolysaccharides	Eicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	15684433
D008070	Lipopolysaccharides	"Fatty Acids, Unsaturated inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	15684433
D008070	Lipopolysaccharides	[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD40 protein	16299289
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CD40 protein	18390722
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD40 mRNA	16317058\|2372405
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD40 protein	11884429\|1524660
D008070	Lipopolysaccharides	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	23724058
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	25843059
D008070	Lipopolysaccharides	4-cresol sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	26784855
D008070	Lipopolysaccharides	daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21945492
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22185406
D008070	Lipopolysaccharides	Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	28811679
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22687549
D008070	Lipopolysaccharides	indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21948866
D008070	Lipopolysaccharides	indole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	21948866
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of CD40 protein	24561310
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with CSF2 protein] results in increased expression of CD40 protein	17512567
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein	21948866
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of CD40 protein	21948866
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD40 protein	17512567
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD40 mRNA	10975854\|1205791
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD40 protein	15618177\|2194549
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	24056979
D008070	Lipopolysaccharides	Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]	24561310
D008070	Lipopolysaccharides	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	20423518
D008070	Lipopolysaccharides	Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22185406
D008070	Lipopolysaccharides	Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	16081843
D008070	Lipopolysaccharides	"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	22185406
D018021	Lithium Chloride	Lithium Chloride results in increased expression of CD40 protein	18455351
D018021	Lithium Chloride	rosiglitazone inhibits the reaction [Lithium Chloride results in increased expression of CD40 protein]	18455351
D008148	Lovastatin	Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]	17507688
D008148	Lovastatin	Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]	17507688
D008148	Lovastatin	Lovastatin inhibits the reaction [TNF protein results in increased expression of CD40 protein]	16472124
D047311	Luteolin	Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D047311	Luteolin	Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]	16601352
D047311	Luteolin	Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein]	16601352
C078795	LW 50020	LW 50020 results in increased expression of CD40 protein	15246609
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD40 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CD40 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in decreased expression of CD40 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
D008628	Mercury	Mercury results in increased expression of CD40 mRNA	16823088
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD40 mRNA	20938992
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	24056979
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CD40 protein	26254549
D015655	1-Methyl-4-phenylpyridinium	TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CD40 protein]	26254549
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]	17507688
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]	17507688
C012258	mevastatin	mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]	17507688
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of CD40 mRNA	21195148
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of CD40 mRNA	21195148
D009151	Mustard Gas	Mustard Gas results in decreased expression of CD40 mRNA	15674843
D009151	Mustard Gas	Mustard Gas results in increased expression of CD40 mRNA	15674843
C455139	myrtucommulone A	myrtucommulone A results in increased expression of CD40 mRNA	26032814
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CD40 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of CD40 mRNA	24768652\|2558310
C029938	nickel sulfate	BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD40 protein]	17636246
C029938	nickel sulfate	nickel sulfate results in increased expression of CD40 protein	17636246\|2567329
D009534	Niclosamide	Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]	24561310
D009761	Nystatin	Nystatin results in increased expression of CD40 protein	16374455
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of CD40 mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CD40 mRNA"	22937105
D010081	Oxazolone	Oxazolone results in increased expression of CD40 mRNA	21893156
D010269	Paraquat	Paraquat results in increased expression of CD40 mRNA	18836921
D052638	Particulate Matter	GSTM1 mutant form promotes the reaction [Particulate Matter results in increased expression of CD40]	21169129
D052638	Particulate Matter	HBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD40]	21169129
D052638	Particulate Matter	Particulate Matter results in increased expression of CD40	21169129
D052638	Particulate Matter	Particulate Matter results in increased expression of CD40 protein	17630318
D052638	Particulate Matter	Particulate Matter results in increased expression of CD40 mRNA	23638009
D052638	Particulate Matter	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]	24192212
D052638	Particulate Matter	Particulate Matter results in increased expression of CD40 protein	24192212
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of CD40 mRNA	23948077
C046012	pentanal	pentanal results in increased expression of CD40 mRNA	26079696
C539933	pevonedistat	pevonedistat affects the expression of CD40 mRNA	24634471
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	23724058
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	20423518
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD40 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of CD40 mRNA	26272509
D010862	Pilocarpine	Pilocarpine results in increased expression of CD40 protein	18455351
D010862	Pilocarpine	rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]	18455351
D010890	Pirenzepine	Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]	16879495
D010936	Plant Extracts	Plant Extracts results in increased expression of CD40 protein	23108216
D028321	Plant Preparations	Plant Preparations results in increased expression of CD40 protein	25019244
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA	28433809
D011070	Poly I-C	[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein	16224278
D011070	Poly I-C	Poly I-C results in increased expression of CD40 protein	15246609
D011134	Polysaccharides	helenalin inhibits the reaction [Polysaccharides results in increased expression of CD40 protein]	15894585
D011134	Polysaccharides	Polysaccharides results in increased expression of CD40 protein	15894585
D011134	Polysaccharides	Polysaccharides results in increased expression of CD40 protein	23108216\|2501924
D017035	Pravastatin	Pravastatin affects the expression of CD40 mRNA	27225895
D017035	Pravastatin	Pravastatin affects the expression of CD40 mRNA	27225895
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]	22717288
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 protein]	22717288
C066229	prolinedithiocarbamate	prolinedithiocarbamate promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]]	22717288
C066229	prolinedithiocarbamate	prolinedithiocarbamate promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of CD40 protein]]	22717288
C066229	prolinedithiocarbamate	resveratrol promotes the reaction [prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]]	22717288
C066229	prolinedithiocarbamate	resveratrol promotes the reaction [prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 protein]]	22717288
C005556	propionaldehyde	propionaldehyde results in increased expression of CD40 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CD40 mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD40 mRNA]	28003376
D011794	Quercetin	Quercetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D011794	Quercetin	Quercetin inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]	15611226
D011794	Quercetin	Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]	22185406
D011794	Quercetin	Quercetin inhibits the reaction [TLR7 protein affects the localization of CD40 protein]	26329008
D011794	Quercetin	Quercetin inhibits the reaction [TLR7 protein results in increased expression of CD40]	26329008
D011794	Quercetin	Quercetin results in increased expression of CD40 mRNA	22185406
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]	16081843
C059514	resveratrol	prolinedithiocarbamate promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]]	22717288
C059514	resveratrol	prolinedithiocarbamate promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of CD40 protein]]	22717288
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]	22717288
C059514	resveratrol	resveratrol promotes the reaction [prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 mRNA]]	22717288
C059514	resveratrol	resveratrol promotes the reaction [prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CD40 protein]]	22717288
C059514	resveratrol	"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of CD40 protein]"	21574786
C034206	Ribomunyl	[Ribomunyl co-treated with IFNG protein] results in increased secretion of CD40 protein	16224278
C034206	Ribomunyl	Ribomunyl results in increased expression of CD40 protein	15246609
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Lithium Chloride results in increased expression of CD40 protein]	18455351
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]	18455351
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CD40 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CD40 mRNA	23221170
D019821	Simvastatin	Simvastatin results in decreased expression of CD40 protein	16387846
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]	17507688
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]	17507688
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]	17507688
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]	17507688
D019821	Simvastatin	Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]	17507688
D019821	Simvastatin	Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]	17507688
D019821	Simvastatin	Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]	17507688
D019821	Simvastatin	Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]	17507688
D019821	Simvastatin	Simvastatin results in decreased expression of CD40 protein	17169357
C439060	sirtinol	sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA]	22717288
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of CD40 mRNA	17936526
D012999	Soman	Soman results in increased expression of CD40 mRNA	19281266
C075117	squalestatin 1	squalestatin 1 affects the expression of CD40 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 affects the expression of CD40 mRNA	27225895
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD40 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CD40 mRNA	26378955
C041348	tcdA protein, Clostridium difficile	"tcdA protein, Clostridium difficile inhibits the reaction [IFNG results in increased expression of CD40 mRNA]"	17507688
C043062	tesmilifene	tesmilifene results in decreased expression of CD40 protein	11306145
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CD40 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD40 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD40 protein	20211938
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CD40 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD40 mRNA	19520675
D013755	Tetradecanoylphorbol Acetate	Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D013755	Tetradecanoylphorbol Acetate	fisetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D013755	Tetradecanoylphorbol Acetate	Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D013755	Tetradecanoylphorbol Acetate	Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein]	16601352
D013755	Tetradecanoylphorbol Acetate	Quercetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]	16601352
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD40 mRNA	16979875
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40 mRNA	25613284
C020809	tetrathiomolybdate	tetrathiomolybdate analog results in increased expression of CD40 mRNA	19323979
D013849	Thimerosal	Thimerosal results in decreased expression of CD40 mRNA	27188386
C023990	tiotidine	[tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein	11306145
C040654	titanium nickelide	titanium nickelide analog results in increased expression of CD40	22287114
C082097	tocotrienol, delta	"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]"	22185406
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of CD40 mRNA"	22185406
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CD40 mRNA"	19647056
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CD40 mRNA"	19682533
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CD40 mRNA	16443354
D014212	Tretinoin	Tretinoin results in increased expression of CD40 protein	15454112
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CD40 mRNA	21893156
D014311	Triprolidine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein	11306145
D014635	Valproic Acid	Valproic Acid affects the expression of CD40 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CD40 mRNA	23179753\|2718838
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CD40 protein	17630318
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CD40 gene	25560391
D001335	Vehicle Emissions	2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]	24192212
D001335	Vehicle Emissions	hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]	24192212
D001335	Vehicle Emissions	hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein]	24192212
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CD40 protein	24192212
C551177	vemurafenib	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CD40 protein	27169980
D014750	Vincristine	Vincristine results in increased expression of CD40 mRNA	23649840
D009536	Niacinamide	Niacinamide promotes the reaction [TNF protein results in increased expression of CD40 mRNA]	22717288
C111237	vorinostat	vorinostat results in increased expression of CD40 mRNA	27188386
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD40 mRNA	16979875
C088658	zoledronic acid	zoledronic acid results in increased expression of CD40 mRNA	24714768
D015054	Zymosan	Zymosan results in increased expression of CD40 protein	15618177

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003823	antigen binding	-	IEA	-
GO:0005515	protein binding	-	IPI	7527023 9468137 12140561 17353931 20676093 23334419 25416956 25910212
GO:0019899	enzyme binding	-	IPI	12223522
GO:0019904	protein domain specific binding	-	IEA	-
GO:0031625	ubiquitin protein ligase binding	-	IPI	11279055
GO:0038023	signaling receptor activity	-	TAS	10092834

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IMP	21410936
GO:0002768	immune response-regulating cell surface receptor signaling pathway	-	IEA	-
GO:0006874	cellular calcium ion homeostasis	-	IMP	21410936
GO:0030168	platelet activation	-	NAS	9468137
GO:0030890	positive regulation of B cell proliferation	-	IEA	-
GO:0032735	positive regulation of interleukin-12 production	-	IEA	-
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0033590	response to cobalamin	-	IEA	-
GO:0034341	response to interferon-gamma	-	IEA	-
GO:0036018	cellular response to erythropoietin	-	IEA	-
GO:0042100	B cell proliferation	-	NAS	8605945
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IMP	21410936
GO:0042832	defense response to protozoan	-	IEA	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEP	12761501
GO:0043406	positive regulation of MAP kinase activity	-	IMP	21410936
GO:0043491	protein kinase B signaling	-	IEA	-
GO:0043536	positive regulation of blood vessel endothelial cell migration	-	IMP	28566713
GO:0043547	positive regulation of GTPase activity	-	IMP	21410936
GO:0045766	positive regulation of angiogenesis	-	IMP	28566713
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	21410936
GO:0048304	positive regulation of isotype switching to IgG isotypes	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0051023	regulation of immunoglobulin secretion	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	21410936
GO:0051607	defense response to virus	-	IEA	-
GO:0065003	protein-containing complex assembly	-	TAS	10748139
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0071347	cellular response to interleukin-1	-	IEA	-
GO:0090037	positive regulation of protein kinase C signaling	-	IMP	21410936
GO:1901652	response to peptide	-	IEA	-
GO:2000353	positive regulation of endothelial cell apoptotic process	-	IDA	12885753

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	10748139
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0009986	cell surface	-	HDA	23981064
GO:0035631	CD40 receptor complex	-	ISS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043196	varicosity	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04514	Cell adhesion molecules (CAMs)
hsa04620	Toll-like receptor signaling pathway
hsa04672	Intestinal immune network for IgA production
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05310	Asthma
hsa05320	Autoimmune thyroid disease
hsa05322	Systemic lupus erythematosus
hsa05330	Allograft rejection
hsa05340	Primary immunodeficiency
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27063419	Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population. (2016 Apr)	Tang W	Tohoku J Exp Med
27043532	Multiplex Immunoassay of Plasma Cytokine Levels in Men with Alcoholism and the Relationship to Psychiatric Assessments. (2016 Mar 29)	Manzardo AM	Int J Mol Sci
18289552	Relation of smoking status to a panel of inflammatory markers: the framingham offspring. (2008 Nov)	Levitzky YS	Atherosclerosis
19046217	Relationship between soluble CD40 ligand and gamma-glutamyltransferase concentrations in non-drinking, young Type 1 diabetic individuals. (2008 Nov)	Zoppini G	Diabet Med
16640741	Traditional risk factor assessment does not capture the extent of cardiovascular risk in systemic lupus erythematosus. (2006 Apr)	Lee AB	Intern Med J
16109925	Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study. (2005 Oct)	de Lemos JA	Arterioscler Thromb Vasc Biol
17908709	Systemic inflammation and COPD: the Framingham Heart Study. (2008 Jan)	Walter RE	Chest
16442901	Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. (2006 Feb)	Hammett CJ	Am Heart J
17925605	Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. (2007 Nov)	Dopheide JF	Coron Artery Dis
15172670	Pathophysiology and biochemistry of cardiovascular disease. (2004 Jun)	Scott J	Curr Opin Genet Dev
8788982	[Immune status and micro-hemodynamic function of patients with chronic alcoholism and liver pathology]. (1995)	Kut'ko II	Zh Nevrol Psikhiatr Im S S Korsakova
22466100	Evaluation of early atherosclerosis in patients with inflammatory bowel disease. (2012 Aug)	Kayahan H	Dig Dis Sci
25541031	Monocyte CD40 expression in young healthy female smokers and/or oral contraceptives users without additional risk factors for atherosclerosis. (2015 Feb)	Parahuleva MS	Thromb Res
22994016	[100 years of Hashimoto thyroiditis, still an intriguing disease]. (2011 Dec)	Baretic M	Acta Med Croatica
29325864	Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases. (2018 Mar)	Shukla SK	Microb Pathog
24783027	Genotype and phenotype predictors of relapse of graves' disease after antithyroid drug withdrawal. (2013 Jan)	Wang PW	Eur Thyroid J
15078798	Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers. (2004 Apr 27)	Harding SA	Circulation
25421156	Role of genetic and non-genetic factors in the etiology of Graves' disease. (2015 Mar)	Marino M	J Endocrinol Invest
28951634	Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking. (2017)	Gong H	Mediators Inflamm
22242199	Genetic factors of autoimmune thyroid diseases in Japanese. (2012)	Ban Y	Autoimmune Dis
21718166	Hemodynamics and metabolism at low versus moderate altitudes. (2011 Summer)	de Leon AC	High Alt Med Biol
19190856	CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosis. (2009 Jun)	Garlichs CD	Inflamm Res
27339572	CD40 ligand and P-selectin in heterozygous Beta-thalassemia. (2016 Jun)	Cikrikcioglu MA	J Pak Med Assoc
19307103	The etiology of autoimmune thyroid disease: a story of genes and environment. (2009 May-Jun)	Tomer Y	J Autoimmun
19047309	Lack of association of soluble CD40 ligand with the presence of acute myocardial infarction or ischemic stroke in the emergency department. (2009 Jan)	Plaikner M	Clin Chem
17531588	Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). (2007 Jun 1)	Thakore AH	Am J Cardiol
22771341	Factors associated with parietal cell autoantibodies in the general population. (2012 Sep)	Cabrera de Leon A	Immunol Lett
20577873	Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women. (2011 May)	Pineda B	Osteoporos Int
16279844	Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (2005 Oct)	Kurylowicz A	Thyroid
19530272	Current insights into the pathogenesis of Graves' orbitopathy. (2009 Jun)	Eckstein AK	Horm Metab Res
22300528	Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. (2012 Feb 2)	Loza MJ	Respir Res
25231450	Thyroid autoimmunity. (2014)	Wiersinga WM	Endocr Dev
11696462	Soluble CD40L and cardiovascular risk in women. (2001 Nov 6)	Schonbeck U	Circulation
20978895	Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study. (2011 Mar)	Kayrak M	Heart Vessels
19564823	Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease. (2009 Jul)	Ueno T	Med Sci Monit
12534350	Autoimmune thyroid disease: propagation and progression. (2003 Jan)	Weetman AP	Eur J Endocrinol
25689051	Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease. (2015)	Li L	PLoS One
22716219	Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study. (2012 Jun 20)	Dallmeier D	Diabetol Metab Syndr
19335079	Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. (2009 Apr)	Marcaccini AM	J Periodontol
25956633	Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls. (2015 Jul)	Hope S	Schizophr Res
18752144	Increased level of platelet microparticles in survivors of myocardial infarction. (2008)	Michelsen AE	Scand J Clin Lab Invest
19734779	Upregulation of platelet CD40, CD40 ligand (CD40L) and P-Selectin expression in cigarette smokers: a flow cytometry study. (2009 Dec)	Neubauer H	Blood Coagul Fibrinolysis
20439292	Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)	van der Helm-van Mil AH	Ann Rheum Dis
27693003	Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers. (2016 Dec)	Antoniewicz L	Atherosclerosis
17043800	Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males. (2007 Feb)	Bonaterra GA	J Mol Med (Berl)
22610351	CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. (2012 Jul)	Shigeta A	Am J Physiol Lung Cell Mol Physiol
26293122	Etiopathogenesis of Basedow's disease. Trends and current aspects. (2015)	Leporati P	Nuklearmedizin
25531109	Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers. (2014)	Arsenault BJ	PLoS One
24779222	[Classification and etiology of hyperthyroidism]. (2014 Mar)	Lacka K	Pol Merkur Lekarski
19622350	Association of CD40 -1C/T polymorphism in the 5'-untranslated region and chronic obstructive pulmonary disease. (2009 Oct)	Liu Y	Clin Chim Acta
19539089	Platelet reactivity in patients with a history of obstructive prosthetic valve thrombosis. (2009 Jun 15)	Bouganim T	Am J Cardiol
20076841	The influence of the menstrual cycle, normal pregnancy and pre-eclampsia on platelet activation. (2010 Feb)	Robb AO	Thromb Haemost
27058955	Cigarette Smoke Decreases the Maturation of Lung Myeloid Dendritic Cells. (2016)	Arellano-Orden E	PLoS One
17396057	Variation in blood levels of inflammatory markers related and unrelated to smoking cessation in women. (2007 Spring)	Hammett CJ	Prev Cardiol
24824543	Association between M1 and M2 macrophages in bronchoalveolar lavage fluid and tobacco smoking in patients with sarcoidosis. (2014)	Osinska I	Pol Arch Med Wewn
17635572	Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes. (2007 Aug)	Tousoulis D	Eur J Clin Invest
23130155	Addition of inflammatory biomarkers did not improve diabetes prediction in the community: the framingham heart study. (2012 Aug)	Dallmeier D	J Am Heart Assoc
24907704	Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations. (2014 Sep)	Ruckerl R	Environ Int
24790730	Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women. (2014)	Pathak A	J Cancer Ther Res
21570531	Peripheral artery disease, biomarkers, and darapladib. (2011 May)	Berger JS	Am Heart J
26567024	Pathogenesis of thyroid eye disease: review and update on molecular mechanisms. (2016 Jan)	Khong JJ	Br J Ophthalmol
29127016	Enhanced activation of circulating plasmacytoid dendritic cells in patients with Chronic Obstructive Pulmonary Disease and experimental smoking-induced emphysema. (2017 Nov 8)	Qiu SL	Clin Immunol
29371709	Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves' disease. (2018 Jan)	Mustafa S	J Pak Med Assoc
27095786	[Effect of CD40 on Foxp3(+) Treg cell in the lung of cigarette smoke exposure mice]. (2016 Apr 12)	Deng TT	Zhonghua Yi Xue Za Zhi