Gene: APOBEC3B

9582
A3B|APOBEC1L|ARCD3|ARP4|DJ742C19.2|PHRBNL|bK150C2.2
apolipoprotein B mRNA editing enzyme catalytic subunit 3B
protein-coding
22q13.1
Ensembl:ENSG00000179750 MIM:607110 Vega:OTTHUMG00000151085 UniprotKB:Q9UH17
NC_000022.11
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.508e-1 (AD)  9.751e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLAC80.537
APOBEC3A0.493
HERC50.486
LILRA50.472
MCM50.458
RARRES30.453
IFI350.451
PARP90.451
IRAK40.449
RNASE30.449

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MESP2-0.278
WNT3-0.276
MAGIX-0.266
LRRC38-0.266
CHRNB3-0.258
SHH-0.257
WNT7A-0.256
SSTR4-0.253
BEND4-0.253
CHRNA4-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of APOBEC3B mRNA"23146750
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of APOBEC3B mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of APOBEC3B mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of APOBEC3B mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of APOBEC3B mRNA21632981
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of APOBEC3B mRNA28522335
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of APOBEC3B mRNA"25351596
C547126AZM551248AZM551248 results in decreased expression of APOBEC3B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APOBEC3B mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APOBEC3B mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of APOBEC3B mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of APOBEC3B mRNA23019147
D004958EstradiolEstradiol results in increased expression of APOBEC3B mRNA16474171|1913916
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of APOBEC3B mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of APOBEC3B mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of APOBEC3B mRNA16474171
D002220CarbamazepineCarbamazepine affects the expression of APOBEC3B mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of APOBEC3B mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of APOBEC3B mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of APOBEC3B mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of APOBEC3B mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of APOBEC3B mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of APOBEC3B mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of APOBEC3B mRNA27989131
D003561CytarabineCytarabine results in increased expression of APOBEC3B mRNA19194470
D000069439DasatinibDasatinib results in decreased expression of APOBEC3B mRNA20579391
C014347decitabinepyrimidin-2-one beta-ribofuranoside inhibits the reaction [APOBEC3B protein results in decreased amination of decitabine]18398609
C014347decitabine[pyrimidin-2-one beta-ribofuranoside results in decreased activity of APOBEC3B protein] which results in increased susceptibility to decitabine18398609
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of APOBEC3B mRNA27392435
D002945CisplatinCisplatin results in increased expression of APOBEC3B mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of APOBEC3B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of APOBEC3B mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of APOBEC3B mRNA23876855
C118739entinostatentinostat results in increased expression of APOBEC3B mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of APOBEC3B mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of APOBEC3B mRNA23649840
D019833GenisteinGenistein results in increased expression of APOBEC3B mRNA16474171
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of APOBEC3B mRNA18951874
D007529IsoflavonesIsoflavones results in decreased expression of APOBEC3B mRNA17374662
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of APOBEC3B mRNA27392435
C544151jinfukangjinfukang results in increased expression of APOBEC3B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of APOBEC3B mRNA26752646
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of APOBEC3B mRNA23649840
D009532NickelNickel results in increased expression of APOBEC3B mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of APOBEC3B mRNA22714537
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of APOBEC3B mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in increased expression of APOBEC3B protein23718831
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of APOBEC3B mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of APOBEC3B mRNA21795739
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside inhibits the reaction [APOBEC3B protein results in decreased amination of decitabine]18398609
C009131pyrimidin-2-one beta-ribofuranoside[pyrimidin-2-one beta-ribofuranoside results in decreased activity of APOBEC3B protein] which results in increased susceptibility to decitabine18398609
D011794QuercetinQuercetin results in increased expression of APOBEC3B mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of APOBEC3B mRNA19167446
D012822Silicon DioxideSilicon Dioxide results in increased expression of APOBEC3B mRNA25351596
C016766sulforafansulforafan results in increased expression of APOBEC3B mRNA26833863
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of APOBEC3B mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of APOBEC3B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APOBEC3B mRNA22298810
C012589trichostatin Atrichostatin A results in increased expression of APOBEC3B mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of APOBEC3B mRNA"26179874
D014520UrethaneUrethane results in decreased expression of APOBEC3B mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOBEC3B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of APOBEC3B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of APOBEC3B mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of APOBEC3B gene29154799
D015032ZincZinc deficiency results in increased expression of APOBEC3B mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003723RNA binding-IBA21873635  
GO:0004126cytidine deaminase activity-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO:0047844deoxycytidine deaminase activity-IMP22457529  
GO ID GO Term Qualifier Evidence PubMed
GO:0010529negative regulation of transposition-IDA16527742  20062055  
GO:0016554cytidine to uridine editing-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0051607defense response to virus-IDA22457529  22915799  
GO:0080111DNA demethylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16699599  21835787  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72200mRNA Editing: C to U ConversionTAS
R-HSA-75072mRNA EditingTAS
R-HSA-75094Formation of the EditosomeTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29695832APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer. (2018 Apr 26)Wang SOncogene
24910434APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development. (2014 Jun 26)Henderson SCell Rep
21995620Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. (2013 May)Liu JAddict Biol
24748981APOBEC3B gene overexpression in non-small-cell lung cancer. (2014 May)Sasaki HBiomed Rep