Gene: WTAP

9589
Mum2
WT1 associated protein
protein-coding
6q25.3
Ensembl:ENSG00000146457 MIM:605442 Vega:OTTHUMG00000015933 UniprotKB:Q15007
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.093e-1 (AD)  4.029e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDELR20.917
EIF4A10.909
RPN10.905
ARF40.904
OSER10.903
EIF2S20.899
PDIA30.897
TMED20.895
TRA2B0.893
SNRPB20.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.677
OR4F29-0.647
P2RY14-0.243
HES5-0.183
TCL1A-0.181
OR2A14-0.166
PRDM14-0.164
C16orf97-0.16
PTGDR2-0.159
PRAMEF17-0.157

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of WTAP mRNA"20816883
D000082AcetaminophenAcetaminophen affects the expression of WTAP mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of WTAP mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of WTAP mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of WTAP mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WTAP mRNA17879257
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WTAP mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of WTAP mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of WTAP mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WTAP mRNA26472689
C054133casticincasticin results in decreased expression of WTAP mRNA28444820
C495817CC-8490CC-8490 results in increased expression of WTAP mRNA15604281
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of WTAP mRNA23650126
D016572CyclosporineCyclosporine results in increased expression of WTAP mRNA20106945
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of WTAP mRNA27638505
D004147DioxinsDioxins affects the expression of WTAP mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of WTAP protein23301498
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of WTAP mRNA]15016801
D005557FormaldehydeFormaldehyde results in increased expression of WTAP mRNA20655997
D005839GentamicinsGentamicins results in increased expression of WTAP mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of WTAP mRNA22634610
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein18951874
C410337K 7174K 7174 results in increased expression of WTAP mRNA24086573
D007649KetamineKetamine results in increased expression of WTAP mRNA20080153
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of WTAP mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WTAP mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of WTAP mRNA29191790
D016685MitomycinWTAP protein affects the susceptibility to Mitomycin16217747
C029938nickel sulfatenickel sulfate results in decreased expression of WTAP mRNA22714537
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of WTAP mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of WTAP mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of WTAP mRNA17426115
C017947sodium arsenitesodium arsenite results in decreased expression of WTAP mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of WTAP mRNA18175754
D013629TamoxifenTamoxifen results in increased expression of WTAP mRNA15604281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WTAP mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WTAP mRNA21354282
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of WTAP mRNA28065790
D014212TretinoinTretinoin results in increased expression of WTAP mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of WTAP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of WTAP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of WTAP gene29154799
D014635Valproic AcidValproic Acid affects the expression of WTAP mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of WTAP mRNA20546886
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of WTAP gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of WTAP mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IMP24407421  
GO:0006397mRNA processing-IEA-  
GO:0007049cell cycle-IEA-  
GO:0008380RNA splicing-IEA-  
GO:0080009mRNA methylation-IBA21873635  
GO:0080009mRNA methylation-IMP24316715  24407421  24981863  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10942595  24316715  26458103  
GO:0005654nucleoplasm-IDA24100041  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0016607nuclear speck-IDA24100041  24407421  
GO:0031965nuclear membrane-IDA10942595  
GO:0036396RNA N6-methyladenosine methyltransferase complex-IDA24316715  24407421  24981863  29348140  29506078  29507755  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers