Gene: CD40LG

959
CD154|CD40L|HIGM1|IGM|IMD3|T-BAM|TNFSF5|TRAP|gp39|hCD40L
CD40 ligand
protein-coding
Xq26.3
Ensembl:ENSG00000102245 MIM:300386 Vega:OTTHUMG00000022512 UniprotKB:P29965
NG_007280.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5930973chrX:136649989 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL2RB0.658
LY90.653
TBX210.649
OR52E40.633
FER1L60.625
COL15A10.622
EOMES0.621
KLRB10.62
KRT720.62
DPPA40.618

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCY2-0.355
NDP-0.351
CABLES1-0.34
CADM1-0.335
KLHDC9-0.333
TMEM56-0.332
GABRG1-0.327
PIGV-0.326
SLC1A4-0.325
SORCS2-0.325

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06475RuplizumabBiotechDrug220651-94-5InvestigationalTarget
ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of CD40LG mRNA19435785
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]24192212
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]24192212
C4574992-chloro-5-nitrobenzanilidehydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]24192212
C4574992-chloro-5-nitrobenzanilidehydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]24192212
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of CD40LG mRNA"22514694
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]"19477266
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]27634759
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]27634759
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]19477266
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased expression of CD40LG protein11297035
D000244Adenosine Diphosphateclopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]11297035
D000244Adenosine Diphosphateclopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]17043144
D0157614-Aminopyridine4-Aminopyridine results in increased expression of CD40LG mRNA24378259
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD40LG mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD40LG mRNA24449571
D047310ApigeninApigenin results in decreased expression of CD40LG16343431
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CD40LG mRNA19962721
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CD40LG protein19962721
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein27430728
C006632arsenic trioxidearsenic trioxide results in increased expression of CD40LG protein27430728
D001241AspirinAspirin results in decreased expression of CD40LG protein15140583|1538105
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of CD40LG protein"15381054
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of CD40LG protein16368305|1917146
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD40LG mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [CD40LG protein results in increased expression of CYP1A1 mRNA]15681594
D004958EstradiolEstradiol affects the expression of CD40LG protein15964915
D001629Bezafibrate[Bezafibrate co-treated with Medroxyprogesterone Acetate] results in decreased activity of CD40LG protein18923439
D001629BezafibrateBezafibrate results in decreased activity of CD40LG protein18923439
C006780bisphenol Abisphenol A results in decreased expression of CD40LG mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CD40LG mRNA19818335
C081643candesartancandesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]16443859
C081643candesartancandesartan results in decreased expression of CD40LG protein16443859
C081643candesartanFenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]16443859
D002244CarbonCarbon affects the expression of CD40LG protein20822968
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]"19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]19477266
D002784CholesterolCholesterol analog results in increased expression of CD40LG mRNA19477266
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CD40LG protein"21574786
D002791Cholesterol, Dietary"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of CD40LG protein]"21574786
C000488cladosporincladosporin results in increased expression of CD40LG mRNA19818335
C055162clopidogrelclopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]11297035
C055162clopidogrelclopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]17043144
C055162clopidogrelclopidogrel results in decreased expression of CD40LG protein19155974
D003474Curcumin[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein27430728
C038459curdlancurdlan affects the expression of CD40LG mRNA19904525
D002945CisplatinCD40LG protein inhibits the reaction [Cisplatin promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]16545138
D002945CisplatinCD40LG protein results in decreased susceptibility to Cisplatin16545138
D002945Cisplatin[Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA21544650
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of CD40LG mRNA24576310
D002117Calcitriol[CD40LG protein co-treated with Calcitriol] results in decreased expression of CD80 protein19186073
D002117Calcitriol[CD40LG protein co-treated with Calcitriol] results in decreased expression of CD86 protein19186073
D002117Calcitriol[CD40LG protein co-treated with Calcitriol] results in decreased secretion of and results in decreased expression of IL1B protein19186073
D002117Calcitriol[CD40LG protein co-treated with Calcitriol] results in decreased secretion of and results in decreased expression of TNF protein19186073
C007517diphenyleneiodonium[CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with diphenyleneiodonium] inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]22295117
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [[CD40LG protein binds to CD40LG protein binds to CD40LG protein] promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased abundance of Reactive Oxygen Species]]22295117
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [[CD40LG protein binds to CD40LG protein binds to CD40LG protein] which results in increased abundance of Reactive Oxygen Species]22295117
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [CD40LG protein results in increased expression of FASLG protein]22295117
D004176DipyridamoleDipyridamole results in decreased secretion of CD40LG protein16046616
D004317DoxorubicinCD40LG protein inhibits the reaction [Doxorubicin promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]16545138
D004317DoxorubicinCD40LG protein results in decreased susceptibility to Doxorubicin16545138
D004317DoxorubicinDoxorubicin promotes the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of H2AFX protein modified form]27634759
D004317DoxorubicinDoxorubicin promotes the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]27634759
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of CD40LG mRNA25398874
C086648eptifibatideeptifibatide results in decreased expression of CD40LG protein16391376
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) affects the expression of CD40LG protein"15964915
D000431EthanolEthanol results in decreased expression of CD40LG protein21574786
D005047EtoposideCD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]16545138
D005047EtoposideCD40LG protein results in decreased susceptibility to Etoposide16545138
D011345Fenofibratecandesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]16443859
D011345FenofibrateFenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]16443859
D011345FenofibrateFenofibrate results in decreased expression of CD40LG protein16443859
C017875fisetinfisetin results in decreased expression of CD40LG16343431
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CD40LG mRNA19962721
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CD40LG protein19962721
D005459FluoridesFluorides results in decreased expression of CD40LG mRNA19962721
D005472FluorouracilFluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]15611226
C039281furanfuran results in increased expression of CD40LG mRNA22079235
C002469fusarenon-Xfusarenon-X results in decreased expression of CD40LG mRNA24983900
C579046GDC-0152GDC-0152 results in increased expression of CD40LG protein22956632
C056507gemcitabinegemcitabine results in decreased expression of CD40LG protein20531411
D005978GlutathioneGlutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]27634759
D005978GlutathioneGlutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]27634759
D006493HeparinHeparin results in decreased expression of CD40LG protein16391376
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CD40LG mRNA26339600
C085278hydroxysafflor yellow Ahydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]24192212
C085278hydroxysafflor yellow Ahydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]24192212
C085278hydroxysafflor yellow Ahydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]24192212
C085278hydroxysafflor yellow Ahydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein]24192212
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG mRNA22851303
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG protein22851303
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of CD40LG mRNA16978161
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CD40LG protein27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD40LG mRNA22802445|2308692
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CD40LG mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CD40LG mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD40LG mRNA10975854
D047311LuteolinLuteolin results in decreased expression of CD40LG16343431
D017258Medroxyprogesterone Acetate[Bezafibrate co-treated with Medroxyprogesterone Acetate] results in decreased activity of CD40LG protein18923439
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased activity of CD40LG protein18923439
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]18269829
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of CD40LG mRNA]16173061
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CD40LG mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CD40LG mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of CD40LG mRNA19818335
C022838nickel chloridenickel chloride affects the expression of CD40LG mRNA24670797
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of CD40LG mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of CD40LG mRNA"22937105
C008729oxaprozinoxaprozin inhibits the reaction [CD40LG protein results in decreased activity of CASP3 protein]19672323
C008729oxaprozinoxaprozin inhibits the reaction [CD40LG protein results in increased phosphorylation of AKT1 protein]19672323
C008729oxaprozinoxaprozin inhibits the reaction [CD40LG protein results in increased phosphorylation of RELA protein]19672323
D010100Oxygen[CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with diphenyleneiodonium] inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]22295117
D010100Oxygen[CD40LG protein binds to CD40LG protein binds to CD40LG protein] promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased abundance of Reactive Oxygen Species]22295117
D010100Oxygendiphenyliodonium inhibits the reaction [[CD40LG protein binds to CD40LG protein binds to CD40LG protein] promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased abundance of Reactive Oxygen Species]]22295117
D017239PaclitaxelCD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]16545138
D017239PaclitaxelCD40LG protein results in decreased susceptibility to Paclitaxel16545138
D052638Particulate MatterParticulate Matter results in decreased expression of CD40LG mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of CD40LG mRNA23638009
D052638Particulate Matter2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]24192212
D052638Particulate Matterhydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]24192212
D052638Particulate Matterhydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]24192212
D052638Particulate MatterParticulate Matter results in increased expression of CD40LG protein24192212
D010424PentobarbitalPentobarbital results in decreased expression of CD40LG mRNA16978161
D059808PolyphenolsPolyphenols results in decreased expression of CD40LG mRNA16293270
D011794QuercetinQuercetin inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]15611226
D011794QuercetinQuercetin results in increased susceptibility to CD40LG protein21750559
D017382Reactive Oxygen SpeciesAcetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]27634759
D017382Reactive Oxygen Species[CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with diphenyleneiodonium] inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]22295117
D017382Reactive Oxygen Species[CD40LG protein binds to CD40LG protein binds to CD40LG protein] promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased abundance of Reactive Oxygen Species]22295117
D017382Reactive Oxygen Species[CD40LG protein binds to CD40LG protein binds to CD40LG protein] which results in increased abundance of Reactive Oxygen Species22295117
D017382Reactive Oxygen Species[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species27634759
D017382Reactive Oxygen Species[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in decreased expression of BCL2L11 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in decreased expression of BCL2 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BCL2A1 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BCL2L1 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BID protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of DDR1 mRNA27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of ICAM1 mRNA27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MCL1 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of NR4A2 mRNA27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of PTGS2 mRNA27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SCO2 protein27634759
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SOCS1 mRNA27634759
D017382Reactive Oxygen Speciesdiphenyliodonium inhibits the reaction [[CD40LG protein binds to CD40LG protein binds to CD40LG protein] promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased abundance of Reactive Oxygen Species]]22295117
D017382Reactive Oxygen Speciesdiphenyliodonium inhibits the reaction [[CD40LG protein binds to CD40LG protein binds to CD40LG protein] which results in increased abundance of Reactive Oxygen Species]22295117
D017382Reactive Oxygen SpeciesGlutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]27634759
C059514resveratrol"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of CD40LG protein]"21574786
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]18269829
D019821SimvastatinSimvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]18269829
D019821SimvastatinSimvastatin results in decreased expression of CD40LG protein17169357
D019821SimvastatinSimvastatin results in decreased expression of CD40LG protein modified form21330348
D019821SimvastatinSimvastatin results in increased expression of CD40LG protein21330348
C017947sodium arsenitesodium arsenite results in decreased expression of CD40LG mRNA12760830
D012969Sodium FluorideSodium Fluoride results in decreased expression of CD40LG mRNA21340527
D013241SterigmatocystinSterigmatocystin results in increased expression of CD40LG mRNA19818335
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD69 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD80 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD86 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CD40LG protein results in increased expression of CD69 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CD40LG protein results in increased expression of CD86 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased susceptibility to CD40LG protein20702590
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD40LG mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with CD40LG protein] results in increased expression of PAX5 mRNA21807014
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with CD40LG protein] results in increased expression of PAX5 protein21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD80 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of PRDM1 mRNA]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of PRDM1 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased susceptibility to CD40LG protein20702590
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD40LG mRNA19520675
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CD40LG protein11297035
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG mRNA22851303
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG protein22851303
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD40LG mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CD40LG mRNA21259345
C402696TMC 120ATMC 120A results in increased expression of CD40LG mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CD40LG protein27793746
D014212TretinoinCD40LG protein promotes the reaction [Tretinoin results in increased expression of CD83 protein]15454112
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD40LG gene25560391
D001335Vehicle Emissions2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]24192212
D001335Vehicle Emissionshydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]24192212
D001335Vehicle Emissionshydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein]24192212
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CD40LG protein24192212
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CD40LG protein27169980
D014747VinblastineCD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]16545138
D014747VinblastineCD40LG protein results in decreased susceptibility to Vinblastine16545138
C025643vinclozolinvinclozolin results in increased expression of CD40LG mRNA18629315
C030852vinorelbine[Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA21544650
C088658zoledronic acidzoledronic acid results in decreased expression of CD40LG mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO:0005174CD40 receptor binding-IPI9468137  
GO:0005515protein binding-IPI15067037  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IDA9468137  
GO:0007159leukocyte cell-cell adhesion-NAS9468137  
GO:0007257activation of JUN kinase activity-IDA15067037  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030168platelet activation-IDA9468137  
GO:0030183B cell differentiation-IEA-  
GO:0031295T cell costimulation-TAS8617933  
GO:0032733positive regulation of interleukin-10 production-IDA8617933  
GO:0032735positive regulation of interleukin-12 production-IDA9922218  
GO:0032753positive regulation of interleukin-4 production-IDA8617933  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0042100B cell proliferation-IDA8605945  
GO:0042102positive regulation of T cell proliferation-IDA8617933  
GO:0043066negative regulation of apoptotic process-IDA12697681  
GO:0045190isotype switching-ISS-  
GO:0048305immunoglobulin secretion-IEA-  
GO:0050776regulation of immune response-TAS-  
GO:0051023regulation of immunoglobulin secretion-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA15067037  
GO:2000353positive regulation of endothelial cell apoptotic process-IDA12885753  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7678552  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-IDA15067037  
GO:0016021integral component of membrane-NAS9468137  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05144Malaria
hsa05145Toxoplasmosis
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05330Allograft rejection
hsa05340Primary immunodeficiency
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25332681Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study. (2014 Dec)Slattery MLMutat Res