Gene: CARTPT

9607
CART
CART prepropeptide
protein-coding
5q13.2
Ensembl:ENSG00000164326 MIM:602606 Vega:OTTHUMG00000131261 UniprotKB:Q16568
NG_015988.1
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.373e-1 (AD)  3.949e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FNDC90.709
TMEM132E0.694
PCDH80.693
RBP40.689
LAMP50.673
CALB10.653
GPR830.653
WIPF30.65
NOL40.647
MAN1C10.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.436
ZFP57-0.41
PRR5L-0.406
RASGRP3-0.394
VRK2-0.384
KLRK1-0.382
SLCO1A2-0.382
TRPV5-0.382
PPFIBP2-0.371
SGMS2-0.366

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CARTPT mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CARTPT mRNA]"29112739
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
D020106AcrylamideAcrylamide results in increased expression of CARTPT mRNA28959563
D000521alpha-MSHalpha-MSH binds to and results in increased activity of CARTPT protein15659233
D0150812-Naphthylamine2-Naphthylamine results in increased expression of CARTPT mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CARTPT mRNA16483693
D000661AmphetamineAmphetamine results in increased expression of CARTPT mRNA16896163|2582535
D000661AmphetamineAmphetamine results in increased expression of CARTPT protein25825358
D000661AmphetamineNPY mutant form promotes the reaction [Amphetamine results in increased expression of CARTPT mRNA]25825358
D000661AmphetamineS-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of CARTPT protein]25825358
D000661AmphetamineS-ethyl glutathione inhibits the reaction [Amphetamine results in increased expression of CARTPT mRNA]25825358
D000735AndrostenedioneCARTPT protein inhibits the reaction [LHB protein results in increased abundance of Androstenedione]19439726
C015001arsenitearsenite results in increased methylation of CARTPT promoter23974009
C120841astressin Bastressin B inhibits the reaction [CARTPT protein results in increased abundance of Corticosterone]15271883
C120841astressin Bastressin B inhibits the reaction [CARTPT protein results in increased secretion of POMC protein alternative form]15271883
D001280AtrazineAtrazine results in decreased expression of CARTPT mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CARTPT mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CARTPT mRNA22228805|2373587
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CARTPT mRNA21839799
D004958EstradiolCARTPT protein results in decreased abundance of Estradiol19439726
D004958EstradiolEstradiol results in increased expression of CARTPT mRNA20068009
D004958EstradiolCARTPT protein inhibits the reaction [BMP2 protein results in increased abundance of Estradiol]23313114
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]19632277
C006780bisphenol Abisphenol A results in increased expression of CARTPT mRNA27641926
C006780bisphenol Abisphenol A results in decreased expression of CARTPT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CARTPT gene28505145
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of CARTPT mRNA19395590
D002713ChlorineChlorine results in decreased expression of CARTPT mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CARTPT mRNA18636392
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CARTPT mRNA18668222
D003024ClozapineClozapine results in decreased expression of CARTPT mRNA14696011
D003042CocaineCocaine results in increased expression of CARTPT mRNA15009677
D003042CocaineCocaine affects the expression of CARTPT mRNA17851536|2018794
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CARTPT mRNA15467011
D003345Corticosteroneastressin B inhibits the reaction [CARTPT protein results in increased abundance of Corticosterone]15271883
D003345CorticosteroneCARTPT protein results in increased abundance of Corticosterone15271883
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CARTPT mRNA26924002
D0151023,4-Dihydroxyphenylacetic Acid"CARTPT protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"15659233
C024629dimethyl phthalatedimethyl phthalate affects the expression of CARTPT mRNA26924002
C118739entinostatentinostat results in decreased expression of CARTPT mRNA27188386
D000431EthanolCARTPT gene mutant form results in increased susceptibility to Ethanol22823101
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of CARTPT mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CARTPT mRNA29112739
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in decreased expression of CARTPT mRNA]29112739
D005411Flame RetardantsFlame Retardants results in decreased expression of CARTPT mRNA29112739
D005473FluoxetineFluoxetine results in decreased expression of CARTPT protein21167239
D004397FonofosFonofos results in increased methylation of CARTPT promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of CARTPT mRNA19167457
C004312glycidolglycidol results in decreased expression of CARTPT mRNA24915197
C062018HU 211HU 211 results in increased expression of CARTPT protein16131814
C056599icariinicariin results in increased expression of CARTPT mRNA19858766
C056599icariinicariin results in increased expression of CARTPT protein19858766
C057416KT 5720KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]19632277
D008070LipopolysaccharidesLipopolysaccharides affects the localization of CARTPT protein12559087
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CARTPT protein12559087
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CARTPT mRNA26924002
D009020MorphineMorphine results in increased expression of CARTPT mRNA20144693
D009538NicotineNicotine results in decreased expression of CARTPT mRNA18247414
D009538NicotineNicotine results in decreased expression of CARTPT protein23623838
D009599NitroprussideNitroprusside affects the cleavage of and affects the expression of CARTPT protein12588509
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of CARTPT mRNA20339368
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CARTPT mRNA18636392
D010278ParathionParathion results in increased methylation of CARTPT promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CARTPT mRNA"25510870
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of CARTPT mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of CARTPT mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CARTPT mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of CARTPT mRNA24780913
C089032rimonabantCARTPT results in increased susceptibility to rimonabant16131814
C089032rimonabantFAAH affects the reaction [rimonabant affects the expression of CARTPT protein]16131814
C089032rimonabantrimonabant affects the expression of CARTPT protein16131814
D012402RotenoneRotenone results in decreased expression of CARTPT mRNA19013527
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of CARTPT mRNA17540011
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of CARTPT protein]25825358
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [Amphetamine results in increased expression of CARTPT mRNA]25825358
D012999SomanSoman results in increased expression of CARTPT mRNA19281266
D013311StreptozocinGHRL protein promotes the reaction [Streptozocin results in decreased expression of CARTPT mRNA]20219977
D013311StreptozocinStreptozocin results in decreased expression of CARTPT mRNA20219977
C012568terbufosterbufos results in increased methylation of CARTPT promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of CARTPT mRNA15977195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CARTPT mRNA15093705
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of CARTPT mRNA"29112739

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI21982860  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-ISS15908120  
GO:0001678cellular glucose homeostasis-IDA11711504  
GO:0007165signal transduction-TAS8647455  
GO:0007186G-protein coupled receptor signaling pathway-ISS15908120  
GO:0007267cell-cell signaling-TAS8647455  
GO:0007268chemical synaptic transmission-IEA-  
GO:0008343adult feeding behavior-ISS-  
GO:0009267cellular response to starvation-IBA21873635  
GO:0009267cellular response to starvation-ISS15680948  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0032099negative regulation of appetite-IBA21873635  
GO:0032099negative regulation of appetite-ISS-  
GO:0032099negative regulation of appetite-TAS11478874  
GO:0032812positive regulation of epinephrine secretion-IDA11711504  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0045671negative regulation of osteoclast differentiation-TAS16614075  
GO:0045777positive regulation of blood pressure-IDA11711504  
GO:0045779negative regulation of bone resorption-IMP16614075  
GO:0050796regulation of insulin secretion-IEA-  
GO:0051971positive regulation of transmission of nerve impulse-IDA11711504  
GO:0070093negative regulation of glucagon secretion-IEA-  
GO:0070253somatostatin secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11711504  
GO:0005615extracellular space-ISS-  
GO:0030141secretory granule-IDA21624661  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18572320Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. (2008 Aug 8)Lohoff FWNeurosci Lett
19183129Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009 Apr)Hansell NKAlcohol Clin Exp Res