Gene: CD47

961
IAP|MER6|OA3
CD47 molecule
protein-coding
3q13.12
Ensembl:ENSG00000196776 MIM:601028 Vega:OTTHUMG00000044216 UniprotKB:Q08722
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.410e-2 (AD)  1.488e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH60.969
ZDHHC170.968
FEM1B0.962
CAND10.962
USP330.961
CUL20.957
CDC270.956
GOPC0.956
RLIM0.956
KLHL420.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.618
OR4F29-0.571
CSAG1-0.401
MTRNR2L10-0.354
MTRNR2L9-0.347
MTRNR2L6-0.347
TFPI2-0.323
FZD10-0.321
MTRNR2L8-0.32
TTLL10-0.32

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CD47 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CD47 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CD47 mRNA"19114083
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of CD47 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CD47 mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CD47 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD47 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD47 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA12419474
C0293704-toluidine4-toluidine results in decreased expression of CD47 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD47 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD47 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CD47 mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of CD47 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CD47 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD47 mRNA24449571
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNA17905399
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CD47 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD47 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD47 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CD47 mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of CD47 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CD47 mRNA12419474
C018475butyraldehydebutyraldehyde results in increased expression of CD47 mRNA26079696
D002104CadmiumCadmium results in decreased expression of CD47 mRNA23369406
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CD47 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CD47 mRNA23650126
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CD47 mRNA18668222
C031180chrysenechrysene results in decreased expression of CD47 mRNA26377693
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD47 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of CD47 mRNA19376846
D003042CocaineCocaine affects the expression of CD47 mRNA20187946
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CD47 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of CD47 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]18200517
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of CD47 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of CD47 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CD47 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CD47 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of CD47 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CD47 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD47 mRNA17602206
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA24690739
D000431EthanolEthanol results in increased expression of CD47 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD47 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD47 mRNA17557909
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of CD47 mRNA9119739
D005419FlavonoidsFlavonoids results in decreased expression of CD47 mRNA18035473
D004397FonofosFonofos results in decreased methylation of CD47 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of CD47 mRNA23649840
C039281furanfuran results in decreased methylation of CD47 gene22079235
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CD47 mRNA19376150
C051890irinotecanirinotecan analog results in increased expression of CD47 mRNA18927307
D048628KetolidesKetolides analog results in increased expression of CD47 mRNA24967691
C008261lead acetatelead acetate results in decreased expression of CD47 mRNA20542052
D001556LindaneLindane results in decreased expression of CD47 mRNA17785943
D008727MethotrexateMethotrexate results in decreased expression of CD47 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CD47 mRNA28001369
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD47 mRNA23649840
D0156551-Methyl-4-phenylpyridinium[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]28268219
D0156551-Methyl-4-phenylpyridinium[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]28268219
D0156551-Methyl-4-phenylpyridinium[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium28268219
D0156551-Methyl-4-phenylpyridiniumNSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]28268219
D0156551-Methyl-4-phenylpyridiniumNSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]28268219
D0156551-Methyl-4-phenylpyridiniumNSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]28268219
D009151Mustard GasMustard Gas results in increased expression of CD47 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CD47 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD47 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD47 mRNA"25554681
D009532NickelNickel results in increased expression of CD47 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of CD47 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of CD47 mRNA17616710
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CD47 mRNA17616710
C487513NSC 23766NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]28268219
C487513NSC 23766NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]28268219
C487513NSC 23766NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]28268219
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CD47 mRNA20971185
D010126OzoneOzone results in decreased expression of CD47 mRNA12763052
D010126OzoneOzone results in increased expression of CD47 mRNA16330353
D017239PaclitaxelCD47 mRNA results in decreased susceptibility to Paclitaxel16322897
D010278ParathionParathion results in decreased methylation of CD47 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of CD47 mRNA17987463
C008776pelargonic acidpelargonic acid results in increased expression of CD47 mRNA11379042
D010416PentachlorophenolPentachlorophenol results in increased expression of CD47 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of CD47 mRNA17381134
D010672PhenytoinPhenytoin results in decreased expression of CD47 mRNA17381134
C006253pirinixic acidpirinixic acid results in increased expression of CD47 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of CD47 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of CD47 mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of CD47 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CD47 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of CD47 protein17337753
D012834SilverSilver results in decreased expression of CD47 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in increased expression of CD47 mRNA18175754
C012568terbufosterbufos results in decreased methylation of CD47 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CD47 mRNA27914987
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD47 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD47 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD47 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD47 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD47 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD47 protein27105554
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD47 mRNA16054898
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of CD47 mRNA"11379042
C483909torcetrapibtorcetrapib results in increased expression of CD47 mRNA23228038
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CD47 mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of CD47 mRNA24935251
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA18200517
C057693troglitazonetroglitazone results in decreased expression of CD47 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD47 mRNA"27188386
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD47 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CD47 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased methylation of CD47 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CD47 mRNA19101580|2438349
D014640VancomycinVancomycin results in decreased expression of CD47 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CD47 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD47 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of CD47 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of CD47 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15383453  25416956  
GO:0070053thrombospondin receptor activity-IBA21873635  
GO:0070053thrombospondin receptor activity-IPI15700281  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007229integrin-mediated signaling pathway-TAS8294396  
GO:0008228opsonization-IEA-  
GO:0008284positive regulation of cell proliferation-IDA15383453  
GO:0009617response to bacterium-IEA-  
GO:0022409positive regulation of cell-cell adhesion-IBA21873635  
GO:0022409positive regulation of cell-cell adhesion-IDA15383453  
GO:0030198extracellular matrix organization-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0050729positive regulation of inflammatory response-IBA21873635  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0050766positive regulation of phagocytosis-IBA21873635  
GO:0050766positive regulation of phagocytosis-IEA-  
GO:0050870positive regulation of T cell activation-IDA15383453  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-IBA21873635  
GO:0070062extracellular exosome-IEA-  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-391160Signal regulatory protein family interactionsTAS
R-HSA-391160Signal regulatory protein family interactionsIEA
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27929051Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. (2016 Dec 8)Fraser SDSci Rep