Gene: GDA

9615
CYPIN|GAH|GUANASE|NEDASIN
guanine deaminase
protein-coding
9q21.13
Ensembl:ENSG00000119125 MIM:139260 Vega:OTTHUMG00000020005 UniprotKB:Q9Y2T3
NG_030562.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.920e-1 (AD)  1.905e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10511997chr9:72145640 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGM2L10.979
PAK30.979
FAXC0.975
NMNAT20.974
MYT1L0.972
FRMPD40.971
SCN2A0.971
MAP7D20.97
GPR1580.97
SVOP0.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.592
RNF135-0.589
HEY2-0.577
YES1-0.57
MYL3-0.57
RAB13-0.567
CHST14-0.56
CNN2-0.556
REST-0.555
RUNX3-0.552

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of GDA mRNA"19162173
C1185591-bromopropane1-bromopropane results in decreased expression of GDA protein21925529
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GDA mRNA"12376462
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDA mRNA]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of GDA mRNA23625689
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GDA mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GDA mRNA"23196670
C0293704-toluidine4-toluidine results in increased expression of GDA mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of GDA mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of GDA protein16687475
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GDA mRNA21641981
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GDA mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GDA mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of GDA mRNA21461292|2782922
D001280AtrazineAtrazine results in increased expression of GDA mRNA23358194
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GDA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GDA mRNA21632981|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GDA mRNA"19150397
C006780bisphenol Abisphenol A results in decreased methylation of GDA gene22576693
C006780bisphenol Abisphenol A results in increased expression of GDA mRNA22576693
C006780bisphenol Abisphenol A affects the expression of GDA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GDA gene28505145
D001761BleomycinBleomycin results in decreased expression of GDA protein25933445
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GDA mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GDA mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of GDA mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GDA mRNA18668222
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GDA mRNA28472532
C031180chrysenechrysene results in increased expression of GDA mRNA26377693
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of GDA mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GDA mRNA]27941970
C016366dibenzothiophenedibenzothiophene results in decreased expression of GDA mRNA23656968
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GDA mRNA]"19467301
D004041Dietary FatsDietary Fats affects the expression of GDA mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of GDA mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of GDA mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GDA mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of GDA mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GDA mRNA28943392
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GDA mRNA"12376462
D004237DiuronDiuron results in decreased expression of GDA mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GDA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GDA mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GDA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GDA mRNA12655037|1583489
D005419FlavonoidsFlavonoids results in decreased expression of GDA mRNA18035473
D005485FlutamideFlutamide results in decreased expression of GDA mRNA24793618
C069837fullerene C60fullerene C60 results in increased expression of GDA mRNA19167457
D019833GenisteinGenistein results in decreased expression of GDA mRNA23019147
D005839GentamicinsGentamicins results in decreased expression of GDA mRNA22061828
D005897GlafenineGlafenine results in increased expression of GDA mRNA24136188
D007052IbuprofenIbuprofen results in increased expression of GDA mRNA28201806
D007545IsoproterenolIsoproterenol results in increased expression of GDA mRNA20003209
D018021Lithium ChlorideLithium Chloride results in increased expression of GDA mRNA23527032
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GDA mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GDA mRNA26378955
D008694MethamphetamineMethamphetamine results in decreased expression of GDA protein19826936
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GDA mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GDA mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GDA mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of GDA mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of GDA mRNA19167457
D009534NiclosamideNiclosamide results in increased expression of GDA mRNA26452273
C012655nimesulidenimesulide results in increased expression of GDA mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GDA protein19716841
D000073878Palm OilPalm Oil affects the expression of GDA mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of GDA mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of GDA mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GDA mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of GDA mRNA18301758
C006253pirinixic acidpirinixic acid results in decreased expression of GDA mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of GDA mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GDA mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of GDA mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of GDA mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of GDA mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of GDA protein17337753
D011794QuercetinQuercetin results in increased expression of GDA mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GDA mRNA25895662
D012834SilverSilver results in decreased expression of GDA mRNA26551752
D012906SmokeSmoke results in increased expression of GDA mRNA21095227
C016104sodium bichromatesodium bichromate results in increased expression of GDA mRNA25993096
D013311StreptozocinStreptozocin results in increased expression of GDA mRNA25905778
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GDA mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GDA mRNA26378955
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDA mRNA]23625689
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GDA mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GDA mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GDA mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GDA mRNA16054898|2121527
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of GDA protein"25852303
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GDA mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of GDA mRNA23411599
C024746tobacco tartobacco tar results in decreased expression of GDA mRNA19559774
C011559tributyltintributyltin results in increased expression of GDA mRNA21683754
D014241TrichloroethyleneTrichloroethylene results in increased expression of GDA mRNA19448997
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GDA mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GDA mRNA"26179874
D014520UrethaneUrethane results in decreased expression of GDA mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of GDA mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of GDA mRNA29154799
D014640VancomycinVancomycin results in decreased expression of GDA mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GDA gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of GDA mRNA25423262
C025643vinclozolinvinclozolin affects the expression of GDA mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of GDA mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10542258  
GO:0008270zinc ion binding-IBA21873635  
GO:0008892guanine deaminase activity-EXP10075721  
GO:0008892guanine deaminase activity-IBA21873635  
GO:0019239deaminase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS10075721  
GO:0006147guanine catabolic process-IEA-  
GO:0006195purine nucleotide catabolic process-TAS-  
GO:0007399nervous system development-TAS10542258  
GO:0046098guanine metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS10542258  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-74259Purine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11410715Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. (2001 Jun)Xu YAlcohol Clin Exp Res