Gene: MTRF1

9617
MRF1|MTTRF1|RF1
mitochondrial translation release factor 1
protein-coding
13q14.11
Ensembl:ENSG00000120662 MIM:604601 Vega:OTTHUMG00000016790 UniprotKB:O75570
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.638e-1 (AD)  2.282e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FASTKD10.862
HERC40.856
ZNF300.852
SNRNP480.851
INTS80.843
KANSL1L0.841
RBM480.841
NAALAD20.84
TRIM520.838
PDS5A0.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.449
OR4F29-0.417
RBP1-0.361
AQP5-0.335
KLRB1-0.333
HPDL-0.32
ENDOU-0.318
CNBD2-0.31
SOX3-0.303
HES5-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of MTRF1 mRNA16014739
D000082AcetaminophenAcetaminophen results in decreased expression of MTRF1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of MTRF1 mRNA17562736
D001280AtrazineAtrazine results in increased expression of MTRF1 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of MTRF1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MTRF1 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of MTRF1 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of MTRF1 mRNA28302478
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTRF1 mRNA17942748
D007213IndomethacinIndomethacin results in increased expression of MTRF1 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MTRF1 mRNA24796395
D008628MercuryMercury results in decreased expression of MTRF1 mRNA19937285
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTRF1 mRNA23649840
C046012pentanalpentanal results in decreased expression of MTRF1 mRNA26079696
C017947sodium arsenitesodium arsenite results in increased expression of MTRF1 mRNA16014739
D012969Sodium FluorideSodium Fluoride results in decreased expression of MTRF1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTRF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTRF1 mRNA17942748
D019284ThapsigarginThapsigargin results in increased expression of MTRF1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of MTRF1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of MTRF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTRF1 mRNA23179753
C111237vorinostatvorinostat results in increased expression of MTRF1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003747translation release factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006415translational termination-IBA21873635  
GO:0006415translational termination-IEA-  
GO:0006449regulation of translational termination-TAS9838146  
GO:0070126mitochondrial translational termination-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep