Gene: CELSR1

9620
ADGRC1|CDHF9|FMI2|HFMI2|ME2
cadherin EGF LAG seven-pass G-type receptor 1
protein-coding
22q13.31
Ensembl:ENSG00000075275 MIM:604523 Vega:OTTHUMG00000150423 UniprotKB:Q9NYQ6
NG_030466.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.741e-1 (AD)  7.922e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16995232chr22:46421424 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26646427chr22:46770870CELSR18.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.792
NPC1L10.763
RAX20.741
C7orf610.724
SLFNL10.703
C9orf1520.703
JMJD60.691
BNIPL0.687
CNTD20.682
SLC7A90.673

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT6B-0.479
HMGB3-0.448
DCAF16-0.429
AGL-0.424
CTSO-0.423
CARF-0.418
RBM3-0.416
ZNF136-0.412
MAP10-0.41
NUDT18-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CELSR1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CELSR1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CELSR1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CELSR1 mRNA20458559
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CELSR1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CELSR1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CELSR1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CELSR1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CELSR1 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of CELSR1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CELSR1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CELSR1 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELSR1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CELSR1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of CELSR1 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of CELSR1 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CELSR1 mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CELSR1 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of CELSR1 mRNA26485663
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CELSR1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR1 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CELSR1 gene16724327
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELSR1 gene20938992
C018091maduramicinmaduramicin results in increased expression of CELSR1 mRNA29128925
D008345ManganeseManganese results in increased expression of CELSR1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of CELSR1 mRNA17175027
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELSR1 gene20938992
D008727MethotrexateMethotrexate affects the expression of CELSR1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CELSR1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CELSR1 mRNA20864626
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CELSR1 mRNA21664453
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CELSR1 mRNA"26251327
C523799MRK 003CELSR1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CELSR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CELSR1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of CELSR1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of CELSR1 mRNA26516004
D010634PhenobarbitalPhenobarbital affects the expression of CELSR1 mRNA23091169
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CELSR1 mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CELSR1 mRNA21427059
D012906SmokeSmoke results in decreased expression of CELSR1 mRNA21095227
D012999SomanSoman results in increased expression of CELSR1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CELSR1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CELSR1 mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CELSR1 mRNA28973375
C009495titanium dioxidetitanium dioxide affects the expression of CELSR1 mRNA23557971
D014212TretinoinTretinoin results in increased expression of CELSR1 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of CELSR1 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CELSR1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CELSR1 mRNA29024780
D014520UrethaneUrethane results in decreased expression of CELSR1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CELSR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CELSR1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of CELSR1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of CELSR1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CELSR1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of CELSR1 mRNA21427059|2769348
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CELSR1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS9339365  
GO:0004930G-protein coupled receptor activity-NAS9339365  
GO:0005509calcium ion binding-IEA-  
GO:0046983protein dimerization activity-NAS9339365  
GO ID GO Term Qualifier Evidence PubMed
GO:0001736establishment of planar polarity-ISS-  
GO:0001764neuron migration-IEA-  
GO:0001843neural tube closure-ISS-  
GO:0001942hair follicle development-IEA-  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-NAS9339365  
GO:0007266Rho protein signal transduction-IEA-  
GO:0007417central nervous system development-NAS9339365  
GO:0007417central nervous system development-TAS10716726  
GO:0007626locomotory behavior-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0032956regulation of actin cytoskeleton organization-IEA-  
GO:0042060wound healing-IEA-  
GO:0042249establishment of planar polarity of embryonic epithelium-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0045176apical protein localization-IEA-  
GO:0048105establishment of body hair planar orientation-IEA-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0060488orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis-IEA-  
GO:0060489planar dichotomous subdivision of terminal units involved in lung branching morphogenesis-IEA-  
GO:0060490lateral sprouting involved in lung morphogenesis-IEA-  
GO:0090179planar cell polarity pathway involved in neural tube closure-IEA-  
GO:0090251protein localization involved in establishment of planar polarity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005887integral component of plasma membrane-TAS9339365  
GO:0016021integral component of membrane-TAS10716726  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27854507Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. (2017 Mar)Hardin MAm J Respir Cell Mol Biol
24649039Association of genetic variants of CELSR1 and 3q28 with hypertension in community-dwelling individuals. (2013 Nov)Ueyama CBiomed Rep
25117632The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population. (2015 Jan)Zhan YHAnn Hum Biol