Gene: KLK4

9622
AI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein
kallikrein related peptidase 4
protein-coding
19q13.41
Ensembl:ENSG00000167749 MIM:603767 Vega:OTTHUMG00000182964 UniprotKB:Q9Y5K2
NG_012154.2
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.012e-1 (AD)  7.388e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs198967chr19:50909765 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs198966chr19:50908754 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPRM0.404
HOXC120.377
SLC22A130.374
OPRM10.372
SLC35G60.366
MAGED40.363
ERVH48-10.355
CYP2A60.351
OR10K10.35
PRAMEF170.349

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXT2-0.269
TNFRSF9-0.268
MT1H-0.268
RGS22-0.257
SLAMF9-0.241
TMEM252-0.24
WEE1-0.235
C22orf31-0.232
C7orf31-0.232
ZNF501-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in increased expression of KLK4 mRNA22595364
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KLK4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLK4 mRNA]17585979
D001151ArsenicArsenic affects the methylation of KLK4 gene25304211
C547126AZM551248AZM551248 results in increased expression of KLK4 mRNA22323515
C006780bisphenol Abisphenol A results in increased expression of KLK4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of KLK427352425
C006780bisphenol Abisphenol A inhibits the reaction [Testosterone results in increased expression of KLK4 protein]27684650
C006780bisphenol Abisphenol A results in decreased expression of KLK4 mRNA25181051|2768465
C006780bisphenol Abisphenol A results in increased expression of KLK4 mRNA23764278
C006780bisphenol Abisphenol A results in increased expression of KLK4 protein23764278
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KLK4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLK4 mRNA]17585979
D003471CuprizoneCuprizone results in increased expression of KLK4 mRNA26577399
D002945CisplatinKLK4 protein affects the susceptibility to Cisplatin16217747
D004178DiquatDiquat affects the expression of KLK4 mRNA22814884
D019833GenisteinGenistein affects the expression of KLK427352425
C492448ICG 001ICG 001 results in decreased expression of KLK4 mRNA26191083
D008627Mercuric ChlorideMercuric Chloride results in increased expression of KLK4 mRNA27188386
D012969Sodium FluorideSodium Fluoride results in decreased secretion of KLK4 protein21626649
D012969Sodium FluorideSodium Fluoride results in decreased expression of KLK4 mRNA27257137
D013739Testosteronebisphenol A inhibits the reaction [Testosterone results in increased expression of KLK4 protein]27684650
D013739TestosteroneTestosterone results in increased expression of KLK4 mRNA27684650
D013739Testosteronevinclozolin inhibits the reaction [Testosterone results in increased expression of KLK4 protein]27684650
C025643vinclozolinvinclozolin affects the expression of KLK427352425
C025643vinclozolinvinclozolin inhibits the reaction [Testosterone results in increased expression of KLK4 protein]27684650
C025643vinclozolinvinclozolin results in decreased expression of KLK4 mRNA27684650

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008236serine-type peptidase activity-NAS10438493  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS10438493  
GO:0022617extracellular matrix disassembly-IBA21873635  
GO:0031214biomineral tissue development-IEA-  
GO:0097186amelogenesis-IBA21873635  
GO:0097186amelogenesis-IMP15235027  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0030141secretory granule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol