Gene info: ID 963

Gene: CD53

GENE ID: 963

Synonyms: MOX44|TSPAN25

Description: CD53 molecule

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000143119 MIM:151525 Vega:OTTHUMG00000048020 UniprotKB:P19397

RefSeq: NC_000001.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : 9.276e-1 (AD) 6.474e-1 (ND) (Frontal_Cortex)

Pascal p-value : 8.765e-1 (AD) 2.391e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7513168	chr1:110870290 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07314983	chr1:111414364	CD53	Promoter	7.431e-5	Alcohol use disorders	26763658
cg10516886	chr1:111415232	CD53	Promoter	2.062e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IRF5	0.818
CD68	0.815
LAPTM5	0.795
CD14	0.79
ITGB2	0.785
LCP2	0.785
CYBB	0.783
C3AR1	0.782
C1QC	0.782
CTSC	0.781

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.368
SOX3	-0.317
SNX22	-0.287
OR4F5	-0.283
HPDL	-0.271
ATP2C2	-0.267
NEUROG2	-0.261
DIAPH3	-0.256
NUTM2A	-0.251
OR4F29	-0.25

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of CD53 mRNA"	19162173
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CD53 mRNA	19933214
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of CD53 mRNA"	19114083
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CD53 mRNA"	25380136
D000082	Acetaminophen	Acetaminophen affects the expression of CD53 mRNA	17562736
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of CD53 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CD53 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD53 mRNA	24449571\|2533912
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CD53 mRNA	15894607
D001554	Benzene	Benzene results in decreased expression of CD53 mRNA	15120971
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD53 mRNA	21569818\|2222880
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD53 mRNA	22228805
C006780	bisphenol A	bisphenol A results in decreased expression of CD53 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CD53 mRNA	18180321
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CD53 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CD53 mRNA	27339419
D002737	Chloroprene	Chloroprene results in decreased expression of CD53 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD53 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CD53 mRNA	22941251
D003471	Cuprizone	Cuprizone results in increased expression of CD53 mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in increased methylation of CD53 promoter	27989131
D003907	Dexamethasone	Dexamethasone results in increased expression of CD53 mRNA	12782123
D003907	Dexamethasone	Dexamethasone results in increased expression of CD53 mRNA	21041162
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of CD53 mRNA	23894361
D002945	Cisplatin	Cisplatin results in increased expression of CD53 mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of CD53 mRNA	22023808
D004041	Dietary Fats	Dietary Fats results in decreased expression of CD53 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of CD53 mRNA	22609946
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CD53 mRNA	21041162
D002117	Calcitriol	Calcitriol results in decreased expression of CD53 mRNA	26485663
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CD53 mRNA	25380136
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CD53 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD53 mRNA	12072388\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD53 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CD53 mRNA	17108234
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD53 mRNA	17351261
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD53 mRNA	23550701
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD53 mRNA	20938992
D004397	Fonofos	Fonofos results in decreased methylation of CD53 promoter	22847954
D005839	Gentamicins	Gentamicins results in increased expression of CD53 mRNA	22061828
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD53 mRNA	25613284
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CD53 protein	17337753
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD53 mRNA	25613284
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD53 mRNA	20938992
C523799	MRK 003	CD53 results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of CD53 mRNA	15674844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CD53 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CD53 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CD53 mRNA	25380136
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of CD53 mRNA	12102619
D000073878	Palm Oil	Palm Oil results in decreased expression of CD53 mRNA	18042831
D010278	Parathion	Parathion results in decreased methylation of CD53 promoter	22847954
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CD53 mRNA	19162173
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CD53 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of CD53 mRNA	19482888
C006253	pirinixic acid	pirinixic acid results in decreased expression of CD53 mRNA	17426115
C045950	propiconazole	propiconazole results in increased expression of CD53 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CD53 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of CD53 mRNA	27029645
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CD53 mRNA	25905778
D018038	Sodium Selenite	Sodium Selenite results in increased expression of CD53 mRNA	18175754
D012999	Soman	Soman results in increased expression of CD53 mRNA	19281266
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CD53 mRNA	25905778
C061133	tamibarotene	tamibarotene results in increased expression of CD53 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of CD53 mRNA	17555576
C012568	terbufos	terbufos results in decreased methylation of CD53 promoter	22847954
C004648	testosterone enanthate	testosterone enanthate affects the expression of CD53 mRNA	17440010
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of CD53 mRNA	28300664
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CD53 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD53 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD53 mRNA	16960034\|2104116
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD53 mRNA	20959002\|2121527
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD53 mRNA	25613284
D013876	Thiophenes	Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CD53 mRNA]	16140955
C009495	titanium dioxide	titanium dioxide results in increased expression of CD53 mRNA	23557971
D014212	Tretinoin	Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CD53 mRNA]	16140955
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CD53 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of CD53 mRNA	15498508\|1614095
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CD53 mRNA	16141432
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of CD53 mRNA	17982090
C022884	undecane	undecane results in increased expression of CD53 protein	17337753
C025643	vinclozolin	vinclozolin results in increased expression of CD53 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CD53 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	21930792

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	NAS	8404042
GO:0007166	cell surface receptor signaling pathway	-	IBA	21873635
GO:0043312	neutrophil degranulation	-	TAS	-
GO:1901741	positive regulation of myoblast fusion	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001772	immunological synapse	-	IDA	21930792
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005911	cell-cell junction	-	ISS	-
GO:0009986	cell surface	-	IEA	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	20458337
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal