Gene: ARHGEF10

9639
GEF10|SNCV
Rho guanine nucleotide exchange factor 10
protein-coding
8p23.3
Ensembl:ENSG00000104728 MIM:608136 Vega:OTTHUMG00000163626 UniprotKB:O15013
NG_008480.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.390e-1 (AD)  2.527e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs749822chr8:1860090 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERS20.871
PREX10.856
WASF20.855
RRBP10.843
MTUS10.84
HPS50.839
VEZF10.838
ZNF240.838
DNM20.837
ADIPOR20.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.455
CRH-0.454
ABCC12-0.435
SLC7A4-0.426
ADRA1D-0.424
OR4F5-0.424
DLX1-0.421
FBLN7-0.416
F7-0.411
PTHLH-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of ARHGEF10 mRNA25596134
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ARHGEF10 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ARHGEF10 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ARHGEF10 mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of ARHGEF10 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARHGEF10 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ARHGEF10 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ARHGEF10 mRNA24449571
D001151ArsenicArsenic affects the methylation of ARHGEF10 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGEF10 mRNA21871943
C044887beta-methylcholinebeta-methylcholine affects the expression of ARHGEF10 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ARHGEF10 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of ARHGEF10 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ARHGEF10 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ARHGEF10 mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of ARHGEF10 mRNA25596134
D002746ChlorpromazineChlorpromazine results in decreased expression of ARHGEF10 mRNA25596134
C059262cidofovircidofovir results in decreased expression of ARHGEF10 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of ARHGEF10 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARHGEF10 mRNA19320972
D003471CuprizoneCuprizone results in decreased expression of ARHGEF10 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of ARHGEF10 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ARHGEF10 mRNA25596134
D016572CyclosporineCyclosporine results in decreased methylation of ARHGEF10 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of ARHGEF10 mRNA25596134
C014347decitabinedecitabine results in increased expression of ARHGEF10 mRNA19194470
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARHGEF10 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ARHGEF10 mRNA25596134
C024565ethylene dichlorideethylene dichloride results in decreased expression of ARHGEF10 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of ARHGEF10 mRNA25596134
D017313FenretinideFenretinide results in decreased expression of ARHGEF10 mRNA28973697
D007069IfosfamideIfosfamide affects the expression of ARHGEF10 mRNA25596134
D008687MetforminMetformin results in decreased expression of ARHGEF10 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of ARHGEF10 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ARHGEF10 mRNA"20188158|2625132
D009966OrphenadrineOrphenadrine affects the expression of ARHGEF10 mRNA23665939
D010100OxygenOxygen deficiency results in increased expression of ARHGEF10 mRNA25596134
C410127PCB 180PCB 180 results in decreased expression of ARHGEF10 mRNA23829299
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ARHGEF10 mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ARHGEF10 protein23718831
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ARHGEF10 mRNA27029645
C089730rosiglitazonerosiglitazone results in decreased expression of ARHGEF10 mRNA25596134
C089730rosiglitazonerosiglitazone results in decreased expression of ARHGEF10 mRNA25596134
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ARHGEF10 mRNA19073995
D013849ThimerosalThimerosal results in decreased expression of ARHGEF10 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased expression of ARHGEF10 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ARHGEF10 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ARHGEF10 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ARHGEF10 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0005089Rho guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0005089Rho guanyl-nucleotide exchange factor activity-IDA16896804  19635168  20042462  
GO:0005515protein binding-IPI19635168  
GO:0019894kinesin binding-IPI19635168  
GO ID GO Term Qualifier Evidence PubMed
GO:0022011myelination in peripheral nervous system-IMP14508709  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0051298centrosome duplication-IMP19635168  
GO:0051496positive regulation of stress fiber assembly-IBA21873635  
GO:0051496positive regulation of stress fiber assembly-IMP16896804  
GO:0090307mitotic spindle assembly-IBA21873635  
GO:0090307mitotic spindle assembly-IMP19635168  
GO:0090630activation of GTPase activity-IDA16896804  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA19635168  
GO:0005829cytosol-NAS16896804  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal