Gene: ZNF592

9640
CAMOS|SCAR5
zinc finger protein 592
protein-coding
15q25.3
Ensembl:ENSG00000166716 MIM:613624 Vega:OTTHUMG00000172490 UniprotKB:Q92610
NG_028094.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.245e-1 (AD)  2.154e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12443381chr15:84770823 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HUWE10.895
NSD10.891
SPECC1L0.891
MCM3AP0.89
SMG50.889
ANKRD110.887
CDC42BPB0.886
NCOA60.882
MPRIP0.879
FAM193A0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.638
OR4F29-0.622
HBD-0.284
ODAM-0.281
CD8B-0.274
AGTR1-0.271
SIM1-0.269
UTS2-0.26
C22orf42-0.257
FOXB1-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000638AmiodaroneAmiodarone results in increased expression of ZNF592 mRNA19774075
C006780bisphenol Abisphenol A affects the expression of ZNF592 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ZNF592 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ZNF592 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF592 mRNA26079696
D002945CisplatinCisplatin results in decreased expression of ZNF592 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ZNF592 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZNF592 protein23301498
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ZNF592 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF592 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZNF592 mRNA26011545
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF592 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ZNF592 gene27618143
C057693troglitazonetroglitazone results in decreased expression of ZNF592 mRNA28973697
D014520UrethaneUrethane results in increased expression of ZNF592 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ZNF592 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of ZNF592 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF592 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal