Gene: IKBKE

9641
IKK-E|IKK-i|IKKE|IKKI
inhibitor of nuclear factor kappa B kinase subunit epsilon
protein-coding
1q32.1
Ensembl:ENSG00000263528 MIM:605048 Vega:OTTHUMG00000184613 UniprotKB:Q14164
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.183e-2 (AD)  6.930e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf1470.784
SLA0.747
STXBP20.746
TLR20.739
SIGLEC90.734
ABI30.734
MSR10.726
TMEM106A0.724
C20.723
SLC7A70.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.433
EDN3-0.344
VIP-0.336
NEUROD6-0.332
KIT-0.326
KCNIP3-0.321
CRH-0.306
WNT7A-0.294
DLX1-0.285
NPBWR1-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IKBKE mRNA"22698814|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IKBKE mRNA]"22698814
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of IKBKE mRNA"21703328
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of IKBKE mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of IKBKE mRNA26690555
D000171AcroleinAcrolein results in decreased expression of IKBKE mRNA18515264
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IKBKE gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IKBKE mRNA19770486
D000452AldrinAldrin results in increased expression of IKBKE mRNA18579281
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA19737545
D001151ArsenicArsenic affects the methylation of IKBKE gene25304211
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IKBKE mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of IKBKE gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IKBKE mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of IKBKE mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IKBKE mRNA12160620
D019327Copper SulfateCopper Sulfate results in increased expression of IKBKE mRNA18579281
C093628cyproconazolecyproconazole results in increased expression of IKBKE mRNA22334560
D003630DaunorubicinIKBKE affects the susceptibility to Daunorubicin18451141
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of IKBKE mRNA24317228
D003907DexamethasoneDexamethasone results in decreased expression of IKBKE mRNA27645313
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of IKBKE mRNA27392435
D002945CisplatinCisplatin results in increased expression of IKBKE mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of IKBKE mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of IKBKE mRNA19680557
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IKBKE mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of IKBKE mRNA]19850644
C014476diethyl maleatediethyl maleate results in decreased expression of IKBKE mRNA25270620
D002117CalcitriolCalcitriol results in increased expression of IKBKE mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of IKBKE mRNA21592394
D004147DioxinsDioxins affects the expression of IKBKE mRNA20463971
C109476epoxiconazoleepoxiconazole results in increased expression of IKBKE mRNA22334560|2397080
C024565ethylene dichlorideethylene dichloride results in increased expression of IKBKE mRNA28189721
D017313FenretinideFenretinide results in increased expression of IKBKE mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IKBKE mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of IKBKE mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IKBKE mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of IKBKE mRNA27392435
C544151jinfukangjinfukang results in increased expression of IKBKE mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IKBKE mRNA23086925|2479639
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of IKBKE mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IKBKE mRNA25890327|2733941
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IKBKE mRNA21641980
D008558MelphalanMelphalan results in decreased expression of IKBKE mRNA22363485
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of IKBKE mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA16357179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of IKBKE mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IKBKE mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IKBKE mRNA"25620056
D009532NickelNickel results in increased expression of IKBKE mRNA25583101
C022838nickel chloridenickel chloride results in decreased expression of IKBKE mRNA21466819
C028007nickel monoxidenickel monoxide results in increased expression of IKBKE mRNA19167457
D010634PhenobarbitalPhenobarbital affects the expression of IKBKE mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of IKBKE mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IKBKE mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IKBKE mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IKBKE mRNA28903501
C045950propiconazolepropiconazole results in increased expression of IKBKE mRNA22334560|2397080
D012822Silicon DioxideSilicon Dioxide results in increased expression of IKBKE mRNA23221170
D012969Sodium FluorideSodium Fluoride results in decreased expression of IKBKE mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IKBKE mRNA21641980
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA"18579281
C013698tallowtallow affects the expression of IKBKE mRNA19680557
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of IKBKE mRNA21592394
D013739TestosteroneTestosterone results in increased expression of IKBKE mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IKBKE mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IKBKE mRNA15328365|1977048
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of IKBKE mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IKBKE mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of IKBKE mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IKBKE mRNA20133372
C032910triadimefontriadimefon results in increased expression of IKBKE mRNA23970803
D014520UrethaneUrethane results in decreased expression of IKBKE mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of IKBKE mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of IKBKE mRNA27645313
D014752Vinyl ChlorideVinyl Chloride results in increased expression of IKBKE mRNA18579281
C029297vinylidene chloridevinylidene chloride results in increased expression of IKBKE mRNA26682919
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of IKBKE mRNA16357179
C088658zoledronic acidzoledronic acid results in increased expression of IKBKE mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS-  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004704NF-kappaB-inducing kinase activity-IDA10882136  
GO:0005515protein binding-IPI14743216  16177806  16281057  17353931  17568778  17599067  
17600090  18636086  18636090  19153231  20188669  20657822  
21212807  21903422  21931555  22939624  23096996  24706939  
25036637  25852190  
GO:0005524ATP binding-IEA-  
GO:0008384IkappaB kinase activity-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI24882218  
GO:0036435K48-linked polyubiquitin modification-dependent protein binding-IMP24882218  
GO:0070530K63-linked polyubiquitin modification-dependent protein bindingNOTIMP24882218  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA10882136  20188669  24882218  
GO:0006955immune response-NAS10421793  
GO:0007252I-kappaB phosphorylation-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IMP20188669  
GO:0010884positive regulation of lipid storage-ISS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0034340response to type I interferon-IEA-  
GO:0035456response to interferon-beta-IMP24882218  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0038061NIK/NF-kappaB signaling-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0051260protein homooligomerization-IDA24882218  
GO:0098586cellular response to virus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20188669  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA20188669  24882218  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-TAS-  
GO:0016605PML body-IDA20188669  
GO:0031966mitochondrial membrane-IMP16876765  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26025939IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro. (2015 May 30)Li WMed Sci Monit