Gene info: ID 9646

Gene: CTR9

GENE ID: 9646

Synonyms: SH2BP1|TSBP|p150|p150TSP

Description: CTR9 homolog, Paf1/RNA polymerase II complex component

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000198730 MIM:609366 Vega:OTTHUMG00000165789 UniprotKB:Q6PD62

RefSeq: NG_051671.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.399e-1 (AD) 6.646e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TOP1	0.922
EPRS	0.921
DHX9	0.916
YTHDF3	0.914
TRIP12	0.913
CAPRIN1	0.913
CRNKL1	0.911
CLINT1	0.911
RSL1D1	0.911
ELAVL1	0.91

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.672
OR4F29	-0.639
CSAG1	-0.21
MTRNR2L6	-0.207
CSAG2	-0.203
RSPO1	-0.2
EN1	-0.197
MTRNR2L10	-0.195
VNN3	-0.192
HMHB1	-0.191

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CTR9 mRNA"	19167446
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CTR9 mRNA"	18648102
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of CTR9 mRNA"	23195993
D001151	Arsenic	Arsenic affects the methylation of CTR9 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of CTR9 mRNA	22982499
C547126	AZM551248	AZM551248 results in decreased expression of CTR9 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CTR9 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of CTR9 mRNA	25210133
C006780	bisphenol A	bisphenol A affects the expression of CTR9 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased methylation of CTR9 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of CTR9 mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of CTR9 mRNA	17484886
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CTR9 mRNA	24386269
D003300	Copper	Copper results in decreased expression of CTR9 mRNA	18522721
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CTR9 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CTR9 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of CTR9 mRNA	19167446
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CTR9 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of CTR9 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CTR9 mRNA	26924002
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CTR9 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTR9 mRNA	17942748
D017313	Fenretinide	Fenretinide results in increased expression of CTR9 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CTR9 mRNA	20044591
C492448	ICG 001	ICG 001 results in decreased expression of CTR9 mRNA	26191083
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of CTR9 mRNA	22802445\|2479639
D007854	Lead	Lead affects the expression of CTR9 mRNA	28903495
C008261	lead acetate	lead acetate results in increased expression of CTR9 mRNA	21829687
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CTR9 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CTR9 mRNA"	20188158
D009532	Nickel	Nickel results in decreased expression of CTR9 mRNA	23195993
D010936	Plant Extracts	Plant Extracts results in increased expression of CTR9 mRNA	23557933
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of CTR9 mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CTR9 mRNA	19073995
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CTR9 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTR9 mRNA	17942748
D019284	Thapsigargin	Thapsigargin results in increased expression of CTR9 protein	24648495
D014520	Urethane	Urethane results in increased expression of CTR9 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of CTR9 mRNA	25979313
D014635	Valproic Acid	Valproic Acid affects the expression of CTR9 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CTR9 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of CTR9 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000993	RNA polymerase II core binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	15923622 16024656 19136632 19410543 20178742 20541477 26496610
GO:0042169	SH2 domain binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001711	endodermal cell fate commitment	-	ISS	-
GO:0001826	inner cell mass cell differentiation	-	IEA	-
GO:0001829	trophectodermal cell differentiation	-	IEA	-
GO:0001832	blastocyst growth	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0007259	JAK-STAT cascade	-	ISS	-
GO:0010390	histone monoubiquitination	-	IDA	16307923
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0016567	protein ubiquitination	-	TAS	-
GO:0019827	stem cell population maintenance	-	IDA	19345177
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	-	IDA	20178742
GO:0033523	histone H2B ubiquitination	-	IDA	16307923
GO:0045638	negative regulation of myeloid cell differentiation	-	IDA	20541477
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	20178742
GO:0051569	regulation of histone H3-K4 methylation	-	IBA	21873635
GO:0051571	positive regulation of histone H3-K4 methylation	-	IMP	16024656
GO:0070102	interleukin-6-mediated signaling pathway	-	ISS	-
GO:0071222	cellular response to lipopolysaccharide	-	ISS	-
GO:0080182	histone H3-K4 trimethylation	-	IMP	16024656
GO:1900364	negative regulation of mRNA polyadenylation	-	IMP	19575011
GO:2000653	regulation of genetic imprinting	-	IEA	-
GO:2001162	positive regulation of histone H3-K79 methylation	-	IMP	16024656
GO:2001168	positive regulation of histone H2B ubiquitination	-	IMP	19575011

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0016593	Cdc73/Paf1 complex	-	IBA	21873635
GO:0016593	Cdc73/Paf1 complex	-	IDA	16307923 20178742
GO:0016607	nuclear speck	-	IEA	-
GO:0035327	transcriptionally active chromatin	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-8852135	Protein ubiquitination	TAS
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28355295	Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. (2017)	Hong EP	PLoS One
28209224	Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)	Webb TR	J Am Coll Cardiol