Gene info: ID 9647

Gene: PPM1F

GENE ID: 9647

Synonyms: CAMKP|CaMKPase|FEM-2|POPX2|hFEM-2

Description: protein phosphatase, Mg2+/Mn2+ dependent 1F

Gene type: protein-coding

Location: 22q11.22

dbXrefs: Ensembl:ENSG00000100034 Vega:OTTHUMG00000150835 UniprotKB:P49593

RefSeq: NC_000022.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.362e-1 (AD) 2.089e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg27653384	chr22:22293118	PPM1F		3.130e-8	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LASP1	0.931
PRRC2B	0.91
PRRC2A	0.909
TAOK2	0.906
EXOC7	0.905
TRAF7	0.904
CARM1	0.899
AP3D1	0.899
TNFAIP1	0.896
TNPO2	0.895

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.683
OR4F29	-0.619
CTNNA3	-0.372
SH2D1A	-0.344
C5orf64	-0.325
TNFRSF13B	-0.311
VNN3	-0.3
IL18RAP	-0.297
MYOT	-0.293
OR6C74	-0.292

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of PPM1F mRNA"	26377693
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PPM1F gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PPM1F mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PPM1F mRNA	16483693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PPM1F mRNA	19152381
D001564	Benzo(a)pyrene	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PPM1F mRNA]	19152381
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PPM1F mRNA	22610609
D004958	Estradiol	Estradiol affects the expression of PPM1F mRNA	22574217
D000069286	Bortezomib	Bortezomib results in increased expression of PPM1F mRNA	20977926
C584509	C646 compound	C646 compound results in increased expression of PPM1F mRNA	26191083
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PPM1F mRNA	12734012
C007020	chlorophyllin	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PPM1F mRNA]	19152381
D003033	Coal Tar	Coal Tar results in increased expression of PPM1F mRNA	27858113
D003976	Diazinon	Diazinon results in decreased methylation of PPM1F gene	22964155
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in increased expression of PPM1F mRNA]	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in increased expression of PPM1F mRNA]	27392435
C069837	fullerene C60	fullerene C60 results in decreased expression of PPM1F mRNA	19167457
D017313	Fenretinide	Fenretinide results in increased expression of PPM1F mRNA	28973697
C492448	ICG 001	ICG 001 results in increased expression of PPM1F mRNA	26191083
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in increased expression of PPM1F mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in increased expression of PPM1F mRNA]	27392435
C544151	jinfukang	jinfukang results in increased expression of PPM1F mRNA	27392435
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PPM1F mRNA"	25554681
C022838	nickel chloride	nickel chloride results in decreased expression of PPM1F mRNA	17312168
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of PPM1F mRNA	21334430
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PPM1F mRNA	24780913
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of PPM1F mRNA"	21148743
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PPM1F mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PPM1F mRNA	25351596
C501413	tesaglitazar	tesaglitazar results in increased expression of PPM1F mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPM1F mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPM1F mRNA	22298810
D014520	Urethane	Urethane results in decreased expression of PPM1F mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased methylation of PPM1F gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of PPM1F mRNA	17963808

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004722	protein serine/threonine phosphatase activity	-	IDA	11559703 11864573 15140879 20801214
GO:0004722	protein serine/threonine phosphatase activity	-	IMP	20016286
GO:0005515	protein binding	-	IPI	11559703 11864573 15140879 18230650 20801214
GO:0033192	calmodulin-dependent protein phosphatase activity	-	IDA	11559703 15140879
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006469	negative regulation of protein kinase activity	-	IDA	11864573
GO:0010628	positive regulation of gene expression	-	IMP	20016286
GO:0010634	positive regulation of epithelial cell migration	-	IMP	20016286
GO:0010811	positive regulation of cell-substrate adhesion	-	IMP	20016286
GO:0016576	histone dephosphorylation	-	IEA	-
GO:0033137	negative regulation of peptidyl-serine phosphorylation	-	IDA	15140879
GO:0035690	cellular response to drug	-	IDA	20801214
GO:0035970	peptidyl-threonine dephosphorylation	-	IDA	11559703 11864573 15140879 20801214
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	11559703
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	-	IDA	15140879
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	20016286
GO:0045927	positive regulation of growth	-	IMP	20016286
GO:0050921	positive regulation of chemotaxis	-	IMP	20016286
GO:0051496	positive regulation of stress fiber assembly	-	IDA	11864573
GO:0051496	positive regulation of stress fiber assembly	-	IMP	20016286
GO:0051894	positive regulation of focal adhesion assembly	-	IMP	20016286
GO:0097193	intrinsic apoptotic signaling pathway	-	IDA	11559703

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	11559703
GO:0032991	protein-containing complex	-	IDA	11864573
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27769050	Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals. (2016 Nov 22)	Tu SH	Oncotarget