Gene: CD58

965
LFA-3|LFA3|ag3
CD58 molecule
protein-coding
1p13.1
Ensembl:ENSG00000116815 MIM:153420 Vega:OTTHUMG00000022749 UniprotKB:P19256
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.698e-2 (AD)  3.966e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26118759chr1:117058474CD587.270e-9Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDELC20.853
MYL12A0.848
ANO60.837
PARP90.835
CMTM60.83
ELF10.828
RP20.827
ADPRH0.826
MYOF0.826
ZNF2170.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.55
MARCH4-0.533
KCNB2-0.525
SLC7A4-0.522
HAS1-0.522
MYADML2-0.519
CALHM1-0.518
BCL11A-0.512
NEUROD6-0.509
PIP5KL1-0.508

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CD58 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CD58 mRNA22230336
D000276Adjuvants, Immunologic"Adjuvants, Immunologic results in increased expression of CD58 protein"11160013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CD58 mRNA27153756
D000536Aluminum HydroxideAluminum Hydroxide results in increased expression of CD58 protein11160013
D001151ArsenicArsenic affects the methylation of CD58 gene25304211
D001151ArsenicArsenic results in increased methylation of CD58 gene27838757
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD58 mRNA21632981|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CD58 mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [CD58 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in decreased expression of CD58 mRNA16705744
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CD58 mRNA24763279
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CD58 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CD58 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CD58 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of CD58 mRNA24834073
D003703DemecolcineDemecolcine results in decreased expression of CD58 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of CD58 gene22964155
D002945CisplatinCisplatin results in decreased expression of CD58 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CD58 mRNA27594783
C118739entinostatentinostat results in increased expression of CD58 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CD58 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CD58 mRNA23649840
D019833GenisteinGenistein results in increased expression of CD58 mRNA16705744
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CD58 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of CD58 mRNA16671099
D007501IronIron deficiency results in increased expression of CD58 mRNA20368581
C544151jinfukangjinfukang results in decreased expression of CD58 mRNA27392435
C410337K 7174K 7174 results in increased expression of CD58 mRNA24086573
D007854LeadLead results in increased expression of CD58 mRNA19921347
D008727MethotrexateMethotrexate results in increased expression of CD58 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD58 mRNA23649840
D008942MitoxantroneCD58 protein affects the susceptibility to Mitoxantrone16217747
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CD58 mRNA"12756304
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CD58 mRNA20971185
D052638Particulate MatterParticulate Matter results in decreased expression of CD58 mRNA17987463
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD58 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CD58 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CD58 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CD58 mRNA22079256
D011794QuercetinQuercetin affects the expression of CD58 mRNA21632981
C016766sulforafansulforafan results in increased expression of CD58 mRNA26833863
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD58 mRNA16979875
C012589trichostatin Atrichostatin A affects the expression of CD58 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of CD58 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD58 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CD58 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CD58 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CD58 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CD58 mRNA17987463
D014750VincristineVincristine results in decreased expression of CD58 mRNA23649840
C111237vorinostatvorinostat results in increased expression of CD58 mRNA27188386
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD58 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-IPI17344209  
GO:0005515protein binding-IPI7544493  10380930  28813417  
GO ID GO Term Qualifier Evidence PubMed
GO:0034113heterotypic cell-cell adhesion-IDA15345303  
GO:0043312neutrophil degranulation-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0071346cellular response to interferon-gamma-IDA19109405  
GO:0071356cellular response to tumor necrosis factor-IDA19109405  
GO:0098609cell-cell adhesion-NAS7544493  
GO:2000484positive regulation of interleukin-8 secretion-IMP19109405  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS7544493  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA15345303  
GO:0016020membrane-HDA19946888  
GO:0030667secretory granule membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16907910Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. (2006 Sep)Lofdahl JMClin Exp Immunol