Gene: SOCS5

9655
CIS6|CISH6|Cish5|SOCS-5
suppressor of cytokine signaling 5
protein-coding
2p21
Ensembl:ENSG00000171150 MIM:607094 Vega:OTTHUMG00000128852 UniprotKB:O75159
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.685e-1 (AD)  7.823e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27496793chr2:46926433SOCS5Promoter7.212e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A460.923
PPM1A0.923
SMIM130.922
SRPK20.918
PPP2R5E0.917
MOB40.917
RBM180.913
SHOC20.912
ADO0.91
PDS5B0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.514
FXYD3-0.406
CSAG1-0.406
RHOD-0.374
SOD3-0.374
CYP11A1-0.372
STON2-0.371
HVCN1-0.37
SIX5-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SOCS5 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SOCS5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS5 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SOCS5 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SOCS5 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of SOCS5 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SOCS5 mRNA"19150397
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of SOCS5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SOCS5 gene28505145
D000069286BortezomibBortezomib results in increased expression of SOCS5 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SOCS5 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SOCS5 promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of SOCS5 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of SOCS5 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SOCS5 mRNA19167446
D003474CurcuminCurcumin results in decreased expression of SOCS5 protein21397623
D003513CycloheximideCycloheximide results in increased expression of SOCS5 mRNA23237828
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of SOCS5 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SOCS5 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SOCS5 mRNA24535843
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of SOCS5 mRNA"15919760
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SOCS5 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SOCS5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS5 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of SOCS5 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of SOCS5 mRNA20655997
D017313FenretinideFenretinide results in increased expression of SOCS5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SOCS5 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SOCS5 mRNA18951874
D007213IndomethacinIndomethacin results in decreased expression of SOCS5 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOCS5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA28628672
D007649KetamineKetamine results in decreased expression of SOCS5 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS5 mRNA15919760
D008558MelphalanMelphalan results in decreased expression of SOCS5 mRNA22363485
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SOCS5 mRNA"20188158
C523799MRK 003SOCS5 results in increased susceptibility to MRK 00319903844
D000073878Palm OilPalm Oil results in increased expression of SOCS5 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased methylation of SOCS5 gene28495853
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOCS5 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SOCS5 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of SOCS5 mRNA]21318169
D011441PropylthiouracilPropylthiouracil results in decreased expression of SOCS5 mRNA24780913
D012524SarinSarin results in decreased expression of SOCS5 mRNA19522546
D012524SarinSarin results in increased expression of SOCS5 mRNA19522546
D012834SilverSilver results in decreased expression of SOCS5 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of SOCS5 mRNA20308225
D013629TamoxifenTamoxifen affects the expression of SOCS5 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS5 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOCS5 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS5 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SOCS5 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS5 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOCS5 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of SOCS5 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SOCS5 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SOCS5 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SOCS5 mRNA26272509
D014520UrethaneUrethane results in increased expression of SOCS5 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SOCS5 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of SOCS5 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SOCS5 gene25560391|2849585

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005154epidermal growth factor receptor binding-IEA-  
GO:0005515protein binding-IPI15590694  24728074  
GO:0030971receptor tyrosine kinase binding-IPI15590694  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007173epidermal growth factor receptor signaling pathway-IEA-  
GO:0007175negative regulation of epidermal growth factor-activated receptor activity-IDA15590694  
GO:0007259JAK-STAT cascade-IEA-  
GO:0009968negative regulation of signal transduction-NAS10773671  
GO:0016567protein ubiquitination-IEA-  
GO:0019221cytokine-mediated signaling pathway-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP15590694  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0045627positive regulation of T-helper 1 cell differentiation-ISS-  
GO:0045629negative regulation of T-helper 2 cell differentiation-ISS-  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0071404cellular response to low-density lipoprotein particle stimulus-IEA-  
GO:0071638negative regulation of monocyte chemotactic protein-1 production-IEA-  
GO:0097699vascular endothelial cell response to fluid shear stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25567908Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)Drilon AClin Cancer Res