Gene: MDC1

9656
NFBD1
mediator of DNA damage checkpoint 1
protein-coding
6p21.33
Ensembl:ENSG00000137337 MIM:607593 Vega:OTTHUMG00000031075 UniprotKB:Q14676
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07257768chr6:30684736MDC14.300e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB10.916
NUP2140.894
ASXL10.878
TTC170.874
FKBP150.873
PHKA20.872
SZT20.871
FNBP40.871
TAF10.866
ANKHD10.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
OR4F29-0.5
KLRC2-0.236
OR4F16-0.234
MOGAT2-0.216
PTH-0.207
MTRNR2L9-0.202
MTRNR2L6-0.194
IAPP-0.194
HCRT-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MDC1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MDC1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MDC1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of MDC1 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of MDC1 mRNA28959563
D000585AminacrineAminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D000585Aminacrine[Aminacrine results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D001151ArsenicArsenic affects the methylation of MDC1 gene25304211
D001374AzacitidineAzacitidine results in increased expression of MDC1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDC1 mRNA25690898
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MDC1 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of MDC1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of MDC1 mRNA20977926
D002166CamptothecinAminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D002166Camptothecin[Aminacrine results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D002166CamptothecinCamptothecin results in increased activity of and affects the localization of MDC1 protein26928355
D002166CamptothecinPropyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D002166Camptothecin[Propyl Gallate results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MDC1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of MDC1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of MDC1 mRNA21878529
D003471CuprizoneCuprizone results in increased expression of MDC1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of MDC1 mRNA20106945|2556210
D003976DiazinonDiazinon affects the expression of MDC1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MDC1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MDC1 mRNA27392435|2759478
D002945CisplatinCisplatin results in increased phosphorylation of MDC1 protein22006019
C000944dicrotophosdicrotophos results in increased expression of MDC1 mRNA28302478
D004026DieldrinDieldrin affects the expression of MDC1 mRNA22546817
D002117CalcitriolCalcitriol results in decreased expression of MDC1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MDC1 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MDC1 protein23301498
D019833GenisteinGenistein results in increased expression of MDC1 mRNA20884965
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MDC1 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MDC1 mRNA23649840
D009151Mustard GasMustard Gas results in increased phosphorylation of MDC1 protein19845377
C022838nickel chloridenickel chloride affects the expression of MDC1 mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MDC1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MDC1 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of MDC1 mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MDC1 mRNA19710929
D011435Propyl GallatePropyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D011435Propyl Gallate[Propyl Gallate results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MDC1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MDC1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDC1 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MDC1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MDC1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MDC1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of MDC1 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of MDC1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of MDC1 mRNA25979313
C025643vinclozolinvinclozolin results in decreased expression of MDC1 mRNA23555832
D024483Vitamin K 3Vitamin K 3 affects the expression of MDC1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12607005  16186822  16377563  18001824  18001825  18583988  
18678890  19234442  19804756  20159462  20224574  21293379  
24240613  25064736  
GO:0008022protein C-terminus binding-IPI17577209  
GO:0070975FHA domain binding-IPI20008512  
GO ID GO Term Qualifier Evidence PubMed
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0031573intra-S DNA damage checkpoint-TAS17577209  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15604234  24217620  24550317  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-ISS-  
GO:0005925focal adhesion-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28574651Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells. (2017 Aug)Mulligan JKInt Forum Allergy Rhinol