Gene: CD59

966
16.3A5|1F5|EJ16|EJ30|EL32|G344|HRF-20|HRF20|MAC-IP|MACIF|MEM43|MIC11|MIN1|MIN2|MIN3|MIRL|MSK21|p18-20
CD59 molecule (CD59 blood group)
protein-coding
11p13
Ensembl:ENSG00000085063 MIM:107271 Vega:OTTHUMG00000166270 UniprotKB:P13987
NG_008057.1
PubMed
0   ANCO-SNPs
ND
4   
4.311e-1 (AD)  9.902e-1 (ND)   (Frontal_Cortex)
2.087e-1 (AD)  2.980e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02224369chr11:33758529CD597.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAPTM4A0.925
TMBIM60.891
CD630.884
FYN0.882
TMED100.88
CD810.875
CLU0.875
RHOA0.87
CYB5B0.868
TMCO10.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.788
OR4F29-0.776
HCRTR1-0.174
ADRA1D-0.165
ABCC12-0.153
ASB18-0.149
DRD5-0.149
COL22A1-0.148
EDN3-0.139
KRT83-0.138

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0032181,3-propane sultone"1,3-propane sultone results in decreased lipidation of CD59 protein"27931811
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CD59 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CD59 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CD59 mRNA"19167446
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CD59 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CD59 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CD59 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CD59 protein20106945
D0150812-Naphthylamine2-Naphthylamine results in increased expression of CD59 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD59 mRNA16483693
D034341Aristolochic AcidsAristolochic Acids results in decreased lipidation of CD59 protein27931811
D001151ArsenicArsenic affects the methylation of CD59 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased mutagenesis of CD59 gene"12361925|1503301
D017638Asbestos, Crocidolite"CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]"12361925
D017638Asbestos, Crocidolite"Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]"12361925|1503301
D001280AtrazineAtrazine results in decreased expression of CD59 mRNA25929836
D001554BenzeneBenzene results in increased expression of CD59 mRNA16188091
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD59 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CD59 protein17045307
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased lipidation of CD59 protein27931811
D001564Benzo(a)pyrene[Benzo(a)pyrene results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein19965957
D001564Benzo(a)pyrene[Benzo(a)pyrene results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein20202993
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CD59 mRNA"19150397
C038328BEP protocolBEP protocol results in increased expression of CD59 mRNA18987330
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CD59 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CD59 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CD59 mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased mutagenesis of CD59 gene15033018
C018475butyraldehydebutyraldehyde results in decreased expression of CD59 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CD59 mRNA18804290
D002699ChlorambucilChlorambucil results in decreased lipidation of CD59 protein27931811
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CD59 mRNA18804290
C018021cobaltous chloridecobaltous chloride results in increased expression of CD59 mRNA24386269
D003078ColchicineColchicine results in increased mutagenesis of CD59 protein17045307
D019327Copper SulfateCopper Sulfate results in increased expression of CD59 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of CD59 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CD59 mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of CD59 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CD59 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein21826740
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CD59 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CD59 protein24798381
D002945CisplatinCisplatin results in decreased lipidation of CD59 protein27931811
C000944dicrotophosdicrotophos results in decreased expression of CD59 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of CD59 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CD59 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein"19965957
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein"20202993
D004121Dimethyl Sulfoxide"Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]"12361925|1503301
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene]12361925
D004237DiuronDiuron results in decreased expression of CD59 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of CD59 protein29385562
D004317DoxorubicinCD59 gene mutant form results in increased susceptibility to Doxorubicin16951374
D004996EthidiumEthidium results in increased mutagenesis of CD59 protein17045307
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD59 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased mutagenesis of CD59 protein17045307
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased lipidation of CD59 protein27931811
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CD59 protein17045307
D005038EthylnitrosoureaEthylnitrosourea results in decreased lipidation of CD59 protein27931811
D005038Ethylnitrosourea[Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein19965957
D005038Ethylnitrosourea[Ethylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein20202993
D005047Etoposide[Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein21826740
C082360fipronilfipronil results in increased expression of CD59 mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of CD59 mRNA18035473
D005485FlutamideFlutamide results in increased expression of CD59 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of CD59 mRNA24136188
C010974glyphosateglyphosate results in decreased expression of CD59 mRNA26302742
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CD59 mRNA15159207
D006861Hydrogen PeroxideCAT protein inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene]12361925
D006861Hydrogen PeroxideDimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene]12361925
D006861Hydrogen PeroxideHydrogen Peroxide results in increased mutagenesis of CD59 gene12361925
D006861Hydrogen PeroxideHydrogen Peroxide results in increased mutagenesis of CD59 protein17045307
C492448ICG 001ICG 001 results in decreased expression of CD59 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CD59 mRNA28628672
C002531isopropylmethanesulfonateisopropylmethanesulfonate results in decreased lipidation of CD59 protein27931811
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CD59 mRNA27392435
D007854LeadLead affects the expression of CD59 mRNA28903495
C008261lead acetatelead acetate results in increased mutagenesis of CD59 protein17045307
D008558MelphalanMelphalan results in decreased lipidation of CD59 protein27931811
D008748MethylcholanthreneMethylcholanthrene results in increased mutagenesis of CD59 protein17045307
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CD59 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD59 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased mutagenesis of CD59 protein17045307
D008770MethylnitrosoureaMethylnitrosourea results in decreased lipidation of CD59 protein27931811
D008770Methylnitrosourea[Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein19965957
D008770Methylnitrosourea[Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein20202993
D016685MitomycinMitomycin results in increased mutagenesis of CD59 protein17045307
D009532NickelNickel results in decreased expression of CD59 mRNA24084258
D009538NicotineNicotine results in increased expression of CD59 mRNA18247414
C012655nimesulidenimesulide results in decreased expression of CD59 mRNA24136188
D0151124-Nitroquinoline-1-oxide[4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein19965957
D0151124-Nitroquinoline-1-oxide[4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein20202993
D052638Particulate MatterParticulate Matter results in increased expression of CD59 mRNA24769257
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CD59 mRNA19095052
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CD59 mRNA26705709
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CD59 mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of CD59 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD59 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD59 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD59 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD59 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD59 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CD59 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in decreased expression of CD59 mRNA24780913
D011794QuercetinQuercetin results in increased expression of CD59 mRNA21632981
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased mutagenesis of CD59 protein"17045307
C017947sodium arsenitesodium arsenite results in decreased expression of CD59 mRNA25879800
C017947sodium arsenitesodium arsenite results in increased mutagenesis of CD59 protein17045307
D012460SulfasalazineSulfasalazine results in decreased expression of CD59 mRNA15625186|1716669
D012460SulfasalazineSulfasalazine results in decreased expression of CD59 protein15625186
C047246temozolomidetemozolomide results in decreased lipidation of CD59 protein27931811
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CD59 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CD59 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CD59 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD59 mRNA22574217
C016134tetrachloroethanetetrachloroethane results in increased mutagenesis of CD59 protein17045307
D013852ThiotepaThiotepa results in decreased lipidation of CD59 protein27931811
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of CD59 mRNA20920546
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CD59 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CD59 mRNA"26179874
D014520UrethaneUrethane results in decreased lipidation of CD59 protein27931811
D014635Valproic AcidValproic Acid results in decreased expression of CD59 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CD59 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CD59 mRNA23665938
C088658zoledronic acidzoledronic acid results in increased expression of CD59 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001848complement binding-IBA21873635  
GO:0005515protein binding-IPI20427317  24036449  
GO ID GO Term Qualifier Evidence PubMed
GO:0001971negative regulation of activation of membrane attack complex-IEA-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007166cell surface receptor signaling pathway-TAS7691713  
GO:0007596blood coagulation-TAS1381503  
GO:0030449regulation of complement activation-IBA21873635  
GO:0030449regulation of complement activation-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0048208COPII vesicle coating-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA15907827  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-TAS1381503  
GO:0030133transport vesicle-TAS-  
GO:0031362anchored component of external side of plasma membrane-IDA9724629  
GO:0031982vesicle-HDA19190083  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24440594Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. (2014 May)Wang LFree Radic Biol Med
21826740Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells. (2011 Dec)Dobrovolsky VNEnviron Mol Mutagen
14633783Chronic myeloproliferative disorders. (2003)Spivak JLHematology Am Soc Hematol Educ Program
19222993Effects of cigarette smoking on the human urinary proteome. (2009 Apr 10)Airoldi LBiochem Biophys Res Commun