Gene: CEP135

9662
CEP4|KIAA0635|MCPH8
centrosomal protein 135
protein-coding
4q12
Ensembl:ENSG00000174799 MIM:611423 Vega:OTTHUMG00000160748 UniprotKB:Q66GS9
NG_032806.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.199e-1 (AD)  2.990e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26542660chr4:56813860CEP1353.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLK0.81
TRPM70.807
PBRM10.797
ATM0.794
AP4E10.793
KIAA15510.792
ZNF3470.791
PKN20.789
ELF20.782
CEPT10.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.348
TNNT1-0.305
OR4F5-0.293
OR4F29-0.291
BTBD17-0.287
DIO2-0.28
ARSF-0.273
GGN-0.267
LCN1-0.266
GSG1-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CEP135 mRNA"20453058
D020106AcrylamideAcrylamide results in increased expression of CEP135 mRNA28959563
D001280AtrazineAtrazine results in increased expression of CEP135 mRNA25929836
D001507BeclomethasoneBeclomethasone results in decreased expression of CEP135 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEP135 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of CEP135 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CEP135 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CEP135 mRNA26472689
D003010ClorgylineClorgyline results in increased expression of CEP135 mRNA19691856
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CEP135 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of CEP135 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of CEP135 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CEP135 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CEP135 mRNA27392435
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CEP135 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CEP135 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CEP135 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CEP135 mRNA27392435
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CEP135 mRNA20971185
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CEP135 mRNA27153767
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CEP135 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CEP135 mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of CEP135 mRNA23557933
D011794QuercetinQuercetin results in increased expression of CEP135 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of CEP135 protein21925251
C061133tamibarotenetamibarotene results in decreased expression of CEP135 mRNA15498508
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CEP135 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CEP135 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of CEP135 gene26756918
D014212TretinoinTretinoin results in decreased expression of CEP135 mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of CEP135 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CEP135 mRNA24935251|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CEP135 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CEP135 mRNA23869203
D014750VincristineVincristine results in increased expression of CEP135 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  20531387  23511974  24997597  26496610  26638075  
27107012  
GO:0008022protein C-terminus binding-IPI18851962  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0007099centriole replication-IMP17681131  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0010457centriole-centriole cohesion-IMP18851962  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:1902857positive regulation of non-motile cilium assembly-IMP26545777  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA21399614  
GO:0005814centriole-IDA17681131  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26756918Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)Zhu XEnviron Health Perspect