Gene: SAFB2

9667
-
scaffold attachment factor B2
protein-coding
19p13.3
Ensembl:ENSG00000130254 MIM:608066 Vega:OTTHUMG00000180374 UniprotKB:Q14151
NG_050735.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.281e-1 (AD)  6.947e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4807045chr19:5621914 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLK30.921
AKAP8L0.913
RFNG0.898
DMPK0.898
AKT20.898
COG70.895
CXXC10.893
TRMT10.891
NELFA0.889
PTDSS20.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.697
OR4F29-0.668
FER1L6-0.302
DNASE1L3-0.297
GZMK-0.293
GADL1-0.291
ASB9-0.27
KLRB1-0.268
SDR42E1-0.268
TTLL10-AS1-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of SAFB2 mRNA20829426
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SAFB2 gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SAFB2 mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of SAFB2 mRNA17326132
C015001arsenitearsenite results in increased methylation of SAFB2 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of SAFB2 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of SAFB2 mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SAFB2 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SAFB2 gene20938992
C031180chrysenechrysene results in increased expression of SAFB2 mRNA26377693
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SAFB2 mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SAFB2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SAFB2 mRNA22079256
D005485FlutamideFlutamide results in increased expression of SAFB2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SAFB2 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SAFB2 mRNA24763279
C492448ICG 001ICG 001 results in decreased expression of SAFB2 mRNA26191083
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SAFB2 gene20938992
D008731MethoxychlorMethoxychlor affects the expression of SAFB2 mRNA20829426
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SAFB2 mRNA29191790
D010936Plant ExtractsPlant Extracts results in increased expression of SAFB2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SAFB2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SAFB2 mRNA22079256
D011794QuercetinQuercetin results in increased expression of SAFB2 mRNA21632981
D012643SeleniumSelenium results in increased expression of SAFB2 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of SAFB2 mRNA29191790
D012834SilverSilver results in increased expression of SAFB2 mRNA27131904
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SAFB2 mRNA28973375
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SAFB2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SAFB2 mRNA28973697
D014520UrethaneUrethane results in increased expression of SAFB2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SAFB2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SAFB2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SAFB2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI12660241  20562859  
GO:0042802identical protein binding-IPI19674106  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0050684regulation of mRNA processing-IBA21873635  
GO:0060008Sertoli cell differentiation-IEA-  
GO:0060765regulation of androgen receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0016604nuclear body-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal