Gene: CD63

967
LAMP-3|ME491|MLA1|OMA81H|TSPAN30
CD63 molecule
protein-coding
12q13.2
Ensembl:ENSG00000135404 MIM:155740 Vega:OTTHUMG00000170454 UniprotKB:P08962
NG_008347.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.812e-1 (AD)  4.628e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PFN10.931
RPLP00.915
GNAI20.909
RPS20.903
DBI0.899
RPS70.899
S100A60.896
GSTP10.895
PPIB0.893
RPL80.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.787
OR4F29-0.779
CDH7-0.218
IL1RAPL2-0.217
COL24A1-0.205
NXPH2-0.205
PCDHA5-0.204
GPR52-0.201
PCDHAC1-0.201
MCHR2-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CD63 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CD63 mRNA"25614096
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD63 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD63 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD63 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CD63 mRNA17562736
D000485AllergensAllergens results in increased expression of CD63 protein18180381
D000485AllergensDasatinib inhibits the reaction [Allergens results in increased expression of CD63 protein]18180381
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD63 mRNA16483693
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of CD63 protein"15381054
C547126AZM551248AZM551248 results in increased expression of CD63 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of CD63 mRNA23656298
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of CD63 mRNA17905399
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD63 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD63 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of CD63 mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of CD63 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CD63 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CD63 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD63 mRNA16239168
C030583ceric oxideceric oxide results in increased expression of CD63 protein23726862
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of CD63 mRNA]"22079312
C100187chloropicrinchloropicrin results in decreased expression of CD63 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD63 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of CD63 mRNA18353800
C019304ciprofibrateciprofibrate results in increased expression of CD63 mRNA12771043
D019327Copper SulfateCopper Sulfate results in increased expression of CD63 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of CD63 mRNA17211630
D003471CuprizoneCuprizone results in increased expression of CD63 mRNA26577399
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD63 mRNA]11007951
D016572CyclosporineCyclosporine results in increased expression of CD63 mRNA20106945|2556210
D000069439DasatinibDasatinib inhibits the reaction [Allergens results in increased expression of CD63 protein]18180381
D000069439DasatinibDasatinib results in decreased expression of CD63 protein18180381
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of CD63 mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of CD63 mRNA"22079312
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CD63 mRNA17379624
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CD63 mRNA21266533
D002945CisplatinCisplatin affects the expression of CD63 mRNA20216102
D004041Dietary FatsDietary Fats results in increased expression of CD63 mRNA15238619|2260994
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CD63 mRNA12771043
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD63 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD63 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CD63 mRNA25380136
D004147DioxinsDioxins affects the expression of CD63 mRNA20463971
D004237DiuronDiuron results in increased expression of CD63 mRNA21551480
D004391DustDust results in decreased expression of CD63 mRNA17805423
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD63 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD63 mRNA17942748
C540355fenamidonefenamidone results in increased expression of CD63 mRNA27029645
C504383fenbuconazolefenbuconazole results in increased expression of CD63 mRNA15942997
D005419FlavonoidsFlavonoids results in increased expression of CD63 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of CD6315485462
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD63 mRNA20938992
D009240N-Formylmethionine Leucyl-PhenylalanineMustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]22036725
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein19887118|2203672
D009240N-Formylmethionine Leucyl-PhenylalanineQuercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]19887118
D009240N-Formylmethionine Leucyl-PhenylalanineSB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]]22036725
C056933fumonisin B1fumonisin B1 results in increased expression of CD63 mRNA16221962
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CD63 mRNA22634610
C010974glyphosateglyphosate results in decreased expression of CD63 mRNA17984146
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CD63 mRNA15159207
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CD63 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD63 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CD63 mRNA27392435
C410337K 7174K 7174 results in increased expression of CD63 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD63 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CD63 mRNA23458150
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of CD63 mRNA17905399
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CD63 protein26558463
D009151Mustard GasMustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]22036725
D009151Mustard GasSB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]]22036725
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD63 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD63 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CD63 mRNA25380136
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD63 mRNA18692542
D010634PhenobarbitalPhenobarbital results in decreased expression of CD63 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD63 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CD63 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CD63 mRNA17690133|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of CD63 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of CD63 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CD63 mRNA27029645
D011794QuercetinQuercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]19887118
D011794QuercetinQuercetin results in increased expression of CD63 mRNA21632981
D012402RotenoneRotenone results in increased expression of CD63 mRNA25682864
D012402RotenoneRotenone results in increased expression of CD63 protein25682864
D012402RotenoneRotenone results in increased expression of CD63 mRNA23186747
C093642SB 203580SB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]]22036725
C009277sodium arsenatesodium arsenate results in increased expression of CD63 mRNA23922661
C017947sodium arsenitesodium arsenite affects the expression of CD63 mRNA20816728
D012999SomanSoman results in increased expression of CD63 mRNA19281266
D013739TestosteroneTestosterone results in increased expression of CD63 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD63 mRNA17884332
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD63 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD63 mRNA11007951|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD63 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD63 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD63 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD63 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of CD63 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of CD63 protein23726862
C009495titanium dioxidetitanium dioxide results in increased expression of CD63 mRNA23557971|2776080
D014118Toxins, Biological"Toxins, Biological affects the expression of CD63 mRNA"19682533
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of CD63 mRNA17905399
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CD63 mRNA19448997
D017974Uranium CompoundsUranium Compounds results in decreased expression of CD63 mRNA19654044
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CD63 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of CD63 mRNA19101580
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CD63 gene25560391
D014810Vitamin EVitamin E results in increased expression of CD63 mRNA19244175
D015034Zinc OxideZinc Oxide results in increased expression of CD63 protein23726862

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16917503  20374249  25312088  
GO ID GO Term Qualifier Evidence PubMed
GO:0002092positive regulation of receptor internalization-IMP23632027  
GO:0002576platelet degranulation-TAS-  
GO:0007155cell adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IMP23632027  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0015031protein transport-IEA-  
GO:0016477cell migration-IBA21873635  
GO:0016477cell migration-IMP23632027  
GO:0034613cellular protein localization-IDA15647390  
GO:0035646endosome to melanosome transport-IMP21962903  
GO:0043312neutrophil degranulation-TAS-  
GO:0045807positive regulation of endocytosis-IBA21873635  
GO:0048757pigment granule maturation-IMP21962903  
GO:1900746regulation of vascular endothelial growth factor signaling pathway-IMP23632027  
GO:1901379regulation of potassium ion transmembrane transport-IDA15647390  
GO:2001046positive regulation of integrin-mediated signaling pathway-IMP16917503  23632027  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA25645918  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005765lysosomal membrane-IDA22431521  23632027  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1993697  
GO:0009986cell surface-IDA15647390  
GO:0010008endosome membrane-IDA15229288  22660413  
GO:0031088platelet dense granule membrane-TAS-  
GO:0031226intrinsic component of plasma membrane-IDA16917503  23632027  
GO:0031902late endosome membrane-IDA23632027  
GO:0031904endosome lumen-IDA22660413  
GO:0032585multivesicular body membrane-HDA12519789  
GO:0032585multivesicular body membrane-IDA26280656  
GO:0035577azurophil granule membrane-TAS-  
GO:0042470melanosome-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070062extracellular exosome-IDA15908444  21505438  23092844  
GO:0097487multivesicular body, internal vesicle-IDA21962903  26280656  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9716156Increased fraction of circulating activated platelets in acute and previous cerebrovascular ischemia. (1998 Aug)Grau AJThromb Haemost
23834268Neutrophil adhesion molecules in experimental rhinovirus infection in COPD. (2013 Jul 8)Mallia PRespir Res
11289709Cigarette smoking as an aggravating factor in inflammatory tissue-destructive diseases. Increase in tumor necrosis Factor-alpha priming of peripheral neutrophils measured as generation of oxygen radicals. (2000)Gustafsson AInt J Clin Lab Res
15013360Young male smokers have altered platelets and endothelium that precedes atherosclerosis. (2004 Feb)Casey RGJ Surg Res
10853859The response of human bone marrow to chronic cigarette smoking. (2000 May)van Eeden SFEur Respir J