Gene: FAM53B

9679
KIAA0140|bA12J10.2|smp
family with sequence similarity 53 member B
protein-coding
10q26.13
Ensembl:ENSG00000189319 MIM:617289 Vega:OTTHUMG00000019215 UniprotKB:Q14153
NC_000010.11
PubMed|SNP Mapped
3   ANCO-SNPs
CD|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.209e-1 (AD)  7.742e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2629540chr10:124737579 (GRCh38.p7)G>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs3781452chr10:124666560 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3781458chr10:124655362 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16404170chr10:126330876FAM53B4.960e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCA20.88
KIAA09300.86
BIN10.857
GTF3C50.856
CDK180.855
CYTH10.854
SEMA4D0.853
FCHO10.851
TPRN0.851
AATK0.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.537
OR4F5-0.524
RGS22-0.295
SDR42E1-0.294
FMO1-0.29
TRDN-0.287
FOXL1-0.282
TTLL10-AS1-0.281
GJB2-0.278
ASB9-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of FAM53B mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FAM53B mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of FAM53B mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of FAM53B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FAM53B gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FAM53B mRNA19770486
D001151ArsenicArsenic affects the methylation of FAM53B gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM53B mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM53B mRNA19770486|2261060
C006780bisphenol Abisphenol A affects the expression of FAM53B mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FAM53B mRNA25181051
D002737ChloropreneChloroprene results in increased expression of FAM53B mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FAM53B mRNA28472532
D016572CyclosporineCyclosporine results in decreased expression of FAM53B mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of FAM53B mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FAM53B mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FAM53B mRNA21266533
D004026DieldrinDieldrin results in increased expression of FAM53B mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of FAM53B mRNA25016146
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM53B mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAM53B mRNA23086925
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM53B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM53B mRNA"25554681|2562005
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM53B mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of FAM53B mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FAM53B mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in decreased expression of FAM53B mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FAM53B mRNA27029645
D012643SeleniumSelenium results in increased expression of FAM53B mRNA19244175
D012834SilverSilver results in increased expression of FAM53B mRNA27131904
D013629TamoxifenTamoxifen results in decreased expression of FAM53B mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM53B mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM53B mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM53B mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FAM53B mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of FAM53B mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FAM53B gene25560391
D014810Vitamin EVitamin E results in increased expression of FAM53B mRNA19244175
D015032ZincZinc deficiency results in increased expression of FAM53B mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016055Wnt signaling pathway-IEA-  
GO:0060828regulation of canonical Wnt signaling pathway-IMP25183871  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP25183871  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25183871  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26581503Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. (2016 Feb)Dickson PEPsychopharmacology (Berl)
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (2014 Jun)Gelernter JMol Psychiatry
29715653Evaluation of previous substance dependence genome-wide significant findings in a Spanish sample. (2018 Jun 1)Pineda-Cirera LDrug Alcohol Depend