Gene info: ID 968

Gene: CD68

GENE ID: 968

Synonyms: GP110|LAMP4|SCARD1

Description: CD68 molecule

Gene type: protein-coding

Location: 17p13.1

dbXrefs: Ensembl:ENSG00000129226 MIM:153634 Vega:OTTHUMG00000108146 UniprotKB:P34810

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 60

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.303e-2 (AD) 4.699e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PTPN6	0.933
LAPTM5	0.933
SPI1	0.932
FCER1G	0.927
C1QC	0.927
LGALS9	0.926
LAIR1	0.923
SASH3	0.923
HAVCR2	0.922
CD300A	0.92

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZSCAN1	-0.388
HES5	-0.386
ATP2C2	-0.379
CPLX3	-0.364
KCNIP3	-0.361
WNT7A	-0.336
SLC7A4	-0.335
MARCH4	-0.334
ABCC12	-0.333
ST6GAL2	-0.332

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C549500	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea inhibits the reaction [AGT protein modified form results in increased expression of CD68 mRNA]	27678262
C400184	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine	1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA	16386258
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CD68 mRNA	19933214
C518860	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	22746536
C568680	(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	22746536
C524106	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	25724490
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CD68 mRNA"	25380136
D000082	Acetaminophen	Acetaminophen affects the expression of CD68 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of CD68 mRNA	19420014
D000082	Acetaminophen	Acetaminophen results in increased expression of CD68 protein	11981759
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of CD68 mRNA	28522335
C005197	alternariol	alternariol results in increased expression of CD68 protein	26341179
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of CD68 mRNA"	22863853
D000968	Antimycin A	Antimycin A results in increased expression of CD68 mRNA	19304788
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD68 mRNA	24449571
C031942	argatroban	argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	22841818
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CD68 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CD68 mRNA	23912714
D001194	Asbestos	Asbestos results in increased expression of CD68 mRNA	22398240
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CD68 mRNA"	19446018
D001280	Atrazine	Atrazine results in increased expression of CD68 mRNA	25929836
C010038	azelaic acid	azelaic acid results in decreased expression of CD68 mRNA	19880116
C547126	AZM551248	AZM551248 results in increased expression of CD68 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD68 mRNA	22228805
D004958	Estradiol	Estradiol affects the expression of CD68 mRNA	25321415
D004958	Estradiol	Estradiol affects the expression of CD68 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of CD68 mRNA	15289156\|1948475
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of CD68 mRNA	21277368
C095105	bexarotene	[bexarotene co-treated with Tamoxifen] results in decreased expression of CD68 mRNA	17630414
C006780	bisphenol A	bisphenol A results in increased expression of CD68 mRNA	25047101
C006780	bisphenol A	bisphenol A results in increased expression of CD68 mRNA	25181051
C025191	bromodichloromethane	[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA	23438451
C025191	bromodichloromethane	gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]	23438451
D002065	Buspirone	Buspirone results in decreased expression of CD68 mRNA	24136188
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA	26177832
D019328	Buthionine Sulfoximine	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]	26177832
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CD68 mRNA	15336504
D020122	tert-Butylhydroperoxide	CD68 protein results in decreased susceptibility to tert-Butylhydroperoxide	15003993
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CD68 mRNA	14729362\|1500399
C018475	butyraldehyde	butyraldehyde results in increased expression of CD68 mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of CD68 mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of CD68 mRNA	17720352
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CD68 mRNA	25993096
C040048	caffeic acid	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA	16806235
D002122	Calcium Chloride	Calcium Chloride results in increased expression of CD68 mRNA	21530968
D002122	Calcium Chloride	resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CD68 mRNA]	21530968
D002211	Capsaicin	Capsaicin results in decreased expression of CD68 mRNA	19798065
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CD68 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CD68 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CD68 protein	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of CD68 protein]	25432964
D002273	Carcinogens	Carcinogens results in decreased expression of CD68 mRNA	22269147
D002330	Carmustine	Carmustine results in decreased expression of CD68 mRNA	15980968
D002392	Catechin	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA	16806235
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD68 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CD68 mRNA	20697377
D002857	Chromium	Chromium inhibits the reaction [Dietary Fats results in increased expression of CD68 protein]	20513351
C503589	cis-9, trans-11-conjugated linoleic acid	"cis-9, trans-11-conjugated linoleic acid affects the expression of CD68 mRNA"	17327424
D004002	Clodronic Acid	Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]	27022031
D003300	Copper	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA	25813056
D003300	Copper	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein	25813056
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CD68 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of CD68 mRNA	26577399\|2752363
D003471	Cuprizone	Cuprizone results in increased expression of CD68 protein	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of CD68 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of CD68 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of CD68 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of CD68 mRNA	21865292
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CD68 mRNA	25549547
D064791	Desoxycorticosterone Acetate	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]	27678262
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA	27678262
D003907	Dexamethasone	Dexamethasone results in increased expression of CD68 protein	10614771
D003907	Dexamethasone	Dexamethasone results in increased expression of CD68 mRNA	21041162
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CD68 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CD68 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CD68 mRNA	20702592
D004041	Dietary Fats	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	25724490
D004041	Dietary Fats	argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	22841818
D004041	Dietary Fats	Chromium inhibits the reaction [Dietary Fats results in increased expression of CD68 protein]	20513351
D004041	Dietary Fats	[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA	23438451
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of CD68 mRNA	28611668
D004041	Dietary Fats	Dietary Fats results in decreased expression of CD68 mRNA	15238619\|1804283
D004041	Dietary Fats	Dietary Fats results in increased expression of CD68 mRNA	22609946\|2284181
D004041	Dietary Fats	Dietary Fats results in increased expression of CD68 protein	20513351\|2561471
D004041	Dietary Fats	gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]	23438451
D004041	Dietary Fats	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of CD68 mRNA]	28611668
D004041	Dietary Fats	Quercetin inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	25614714
D004041	Dietary Fats	Quercetin inhibits the reaction [Dietary Fats results in increased expression of CD68 protein]	25614714
D004041	Dietary Fats	[Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA	19632207
D000073417	Dietary Sugars	[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of CD68 mRNA	28611668
D000073417	Dietary Sugars	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of CD68 mRNA]	28611668
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD68 mRNA	28943392
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CD68 mRNA	15289156
D002117	Calcitriol	Calcitriol results in increased expression of CD68 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of CD68 mRNA	21592394
D000069462	Dimethyl Fumarate	"Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	27277809
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CD68 mRNA	25380136
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CD68 protein	18371158
D004128	Dimethylnitrosamine	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of CD68 protein]"	18371158
D004317	Doxorubicin	Doxorubicin results in increased expression of CD68 mRNA	25896364
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of CD68 protein]"	18371158
D000431	Ethanol	Ethanol results in increased expression of CD68 mRNA	26858005
D000431	Ethanol	[Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA	26858005
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CD68 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD68 mRNA	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD68 mRNA	17351261\|1755790
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency promotes the reaction [NR1H2 gene mutant form results in increased expression of CD68 mRNA]"	23333450
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency promotes the reaction [NR1H3 gene mutant form results in increased expression of CD68 mRNA]"	23333450
C540355	fenamidone	fenamidone results in increased expression of CD68 mRNA	27029645
D005485	Flutamide	Flutamide results in decreased expression of CD68 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of CD68 mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD68 mRNA	20938992
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA	28123933
D005632	Fructose	[Fructose co-treated with Ethanol] results in increased expression of CD68 mRNA	26858005
D005632	Fructose	[Dietary Fats co-treated with Fructose] results in increased expression of CD68 mRNA	19632207
D005632	Fructose	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA	25813056
D005632	Fructose	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein	25813056
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]	23438451
C038958	gadolinium chloride	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA	25813056
C038958	gadolinium chloride	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein	25813056
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]	26177832
D019833	Genistein	Genistein results in increased expression of CD68 mRNA	15289156
D005839	Gentamicins	Gentamicins results in increased expression of CD68 mRNA	22061828
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of CD68 mRNA	22467014
C412815	GW 4064	GW 4064 results in decreased expression of CD68 mRNA	23371517
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CD68 mRNA	21179406
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CD68 mRNA	14729362\|1500399
C541917	INT 131	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of CD68 mRNA]	28611668
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD68 mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CD68 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CD68 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of CD68 mRNA	24086573
D007608	Kainic Acid	Kainic Acid results in increased expression of CD68 mRNA	19700661
C008261	lead acetate	lead acetate results in increased expression of CD68 mRNA	21829687
D044243	Linoleic Acids, Conjugated	"Linoleic Acids, Conjugated results in increased expression of CD68 mRNA"	17322064
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD68 mRNA	27339419
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD68 protein	28693884
D008466	Mechlorethamine	Mechlorethamine results in increased expression of CD68 protein	26273949
D015122	Mercaptopurine	Mercaptopurine results in increased expression of CD68 mRNA	23358152
D008701	Methapyrilene	Methapyrilene results in increased expression of CD68 mRNA	28935588
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA	26177832
D008713	Methimazole	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]	26177832
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD68 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CD68 mRNA	20697377
D008727	Methotrexate	Methotrexate results in decreased expression of CD68 mRNA	19732956
D008727	Methotrexate	Methotrexate results in decreased expression of CD68 protein	15476228
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of CD68 mRNA	27544571
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA"	22746536\|2727780
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	22746536
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	22746536
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA]"	27277809
D009151	Mustard Gas	Mustard Gas results in increased expression of CD68 mRNA	25102026
D009153	Mutagens	Mutagens results in decreased expression of CD68 mRNA	22269147
C502260	N-(1-methylethyl)-1,1,2-trimethylpropylamine	"N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Rotenone results in increased expression of CD68 protein]"	17356569
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CD68 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CD68 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CD68 mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of CD68 mRNA	19812364
C119536	nickel acetate	nickel acetate affects the expression of CD68 mRNA	12915101
C037473	nickel hydroxide (II)	nickel hydroxide (II) analog results in increased expression of CD68 mRNA	20864429
C028007	nickel monoxide	nickel monoxide results in increased expression of CD68 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of CD68 mRNA	22714537
C013150	nifuroxazide	nifuroxazide inhibits the reaction [Streptozocin results in increased expression of CD68 protein]	29291386
C012655	nimesulide	nimesulide results in decreased expression of CD68 mRNA	24136188
D017239	Paclitaxel	Paclitaxel results in increased expression of CD68 protein	16854522
D000073878	Palm Oil	Palm Oil results in decreased expression of CD68 mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of CD68 mRNA	21371552
D052638	Particulate Matter	CCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of CD68 mRNA]	24149114
D052638	Particulate Matter	Particulate Matter results in increased expression of CD68 mRNA	23638009\|2414911
D052638	Particulate Matter	Particulate Matter results in increased expression of CD68 protein	19683567
D010476	Perfume	Perfume results in increased expression of CD68 mRNA	24768652
D015232	Dinoprostone	Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of CD68 protein]	25432964
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CD68 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of CD68 mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD68 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in increased expression of CD68 mRNA	28533734
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of CD68 mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of CD68 mRNA	23012394
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of CD68 mRNA	21277368
C005556	propionaldehyde	propionaldehyde results in increased expression of CD68 mRNA	26079696
C029658	propionic acid	propionic acid results in increased expression of CD68 protein	16950524
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CD68 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of CD68 mRNA	27029645
D011794	Quercetin	Quercetin inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA]	25614714
D011794	Quercetin	Quercetin inhibits the reaction [Dietary Fats results in increased expression of CD68 protein]	25614714
C059514	resveratrol	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA	16806235
C059514	resveratrol	resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CD68 mRNA]	21530968
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CD68 mRNA	25905778
C089730	rosiglitazone	rosiglitazone results in increased expression of CD68 mRNA	21515302
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of CD68 protein	28789951
D012402	Rotenone	Rotenone results in increased expression of CD68 mRNA	19304788\|2318674
D012402	Rotenone	"N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Rotenone results in increased expression of CD68 protein]"	17356569
D012402	Rotenone	Rotenone results in increased expression of CD68 protein	17356569
D012431	Rutin	Rutin results in decreased expression of CD68 protein	28693884
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CD68 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CD68 mRNA	22431001
D012834	Silver	Silver results in increased expression of CD68 mRNA	27131904
D020123	Sirolimus	Sirolimus results in decreased expression of CD68 mRNA	17016853
D020123	Sirolimus	Sirolimus results in decreased expression of CD68 mRNA	21865292
C017947	sodium arsenite	sodium arsenite results in increased expression of CD68 mRNA	22714537
D012965	Sodium Chloride	CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]	27678262
D012965	Sodium Chloride	[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA	27678262
D053260	Soot	Soot results in increased expression of CD68 mRNA	22461453\|2655175
D013311	Streptozocin	nifuroxazide inhibits the reaction [Streptozocin results in increased expression of CD68 protein]	29291386
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CD68 mRNA	25905778
D013311	Streptozocin	Streptozocin results in increased expression of CD68 protein	29291386
C016766	sulforafan	sulforafan results in increased expression of CD68 mRNA	26833863
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of CD68 mRNA	22467014
D016559	Tacrolimus	Tacrolimus results in increased expression of CD68 mRNA	21865292
C061133	tamibarotene	tamibarotene results in decreased expression of CD68 mRNA	20861477
D013629	Tamoxifen	Tamoxifen affects the expression of CD68 mRNA	17555576
D013629	Tamoxifen	[bexarotene co-treated with Tamoxifen] results in decreased expression of CD68 mRNA	17630414
C021751	tanshinone	tanshinone results in decreased expression of CD68 protein	20854809
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of CD68 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of CD68 mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of CD68 mRNA	28300664
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CD68 mRNA	21570461\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD68 mRNA	27713108
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD68 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CD68 protein	25128825\|2872048
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD68 mRNA	25613284
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD68 mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of CD68 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CD68 protein	28720485
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of CD68 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CD68 mRNA	20133372
C011559	tributyltin	tributyltin results in increased expression of CD68 protein	25819109
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CD68 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of CD68 mRNA	29024780
D014520	Urethane	Urethane results in increased expression of CD68 mRNA	28818685
D000068756	Valsartan	Valsartan results in decreased expression of CD68 mRNA	22768174
C025643	vinclozolin	vinclozolin results in increased expression of CD68 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CD68 mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in increased expression of CD68 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0071310	cellular response to organic substance	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0010008	endosome membrane	-	IEA	-
GO:0016020	membrane	-	TAS	7680921
GO:0016021	integral component of membrane	-	IEA	-
GO:0035577	azurophil granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04142	Lysosome

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10648081	The relationship between the angiographic findings and the clinical features of carotid artery plaque. (2000)	Kim DI	Surg Today
20477652	Cilomilast, an orally active phosphodiesterase 4 inhibitor for the treatment of COPD. (2005 May)	Baeumer W	Expert Rev Clin Immunol
21681974	Clinical and immunological characteristics associated with the presence of protozoa in sputum smears. (2013 Jan)	Martinez-Giron R	Diagn Cytopathol
23717691	Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer. (2013)	Zhang W	PLoS One
29089751	Characteristics and potential role of M2 macrophages in COPD. (2017)	He S	Int J Chron Obstruct Pulmon Dis
20163570	Smoking attenuates wound inflammation and proliferation while smoking cessation restores inflammation but not proliferation. (2010 Mar-Apr)	Sorensen LT	Wound Repair Regen
10802223	Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease. (2000 Mar 15)	Rahman I	Free Radic Biol Med
23790077	Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke-Korsakoff syndrome. (2013 Dec)	Wijnia JW	Eur J Neurol
8564109	Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration of the bronchial mucosa. (1996 Feb)	Di Stefano A	Am J Respir Crit Care Med
17504799	Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis. (2007 Sep)	Gamble E	Eur Respir J
27552197	Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways. (2016)	Fattahi F	PLoS One
25826501	Macrophage response in patients diagnosed with aseptic necrosis of the femoral head presenting different risk factors. (2015)	Kamal D	Rom J Morphol Embryol
18445768	Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques. (2008 Jul)	Li W	Exp Biol Med (Maywood)
22797933	Impact of opiate addiction on neuroinflammation in HIV. (2012 Oct)	Byrd D	J Neurovirol
10607796	Ongoing airway inflammation in patients with COPD who do not currently smoke. (2000 Jan)	Rutgers SR	Thorax
27864166	Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: An Autopsy Study Protocol. (2016 Nov 18)	Farias-Itao DS	JMIR Res Protoc
18273488	Perinatal and infant early atherosclerotic coronary lesions. (2008 Feb)	Milei J	Can J Cardiol
24876670	Active smoking increases microsomal PGE2-synthase-1/PGE-receptor-4 axis in human abdominal aortic aneurysms. (2014)	Dilme JF	Mediators Inflamm
8586328	[Characterization of bronchoalveolar space cells in pulmonary sarcoidosis]. (1994)	Czarnobilska E	Folia Med Cracov
26632403	Smoking-Related Renal Histologic Injury in IgA Nephropathy Patients. (2016 Jan)	Cha YJ	Yonsei Med J
23639272	CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma. (2013 Jul)	Ravensberg AJ	Respir Med
27745858	Immunohistological Analysis of Intracoronary Thrombus Aspirate in STEMI Patients: Clinical Implications of Pathological Findings. (2017 Mar)	Blasco A	Rev Esp Cardiol (Engl Ed)
24980077	Influence of cardiovascular risk factors on levels of matrix metalloproteinases 2 and 9 in human abdominal aortic aneurysms. (2014 Oct)	Dilme JF	Eur J Vasc Endovasc Surg
15607122	Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPD. (2005)	Jeffery P	Pulm Pharmacol Ther
28370244	Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients. (2017 Jun)	Janssen KMJ	J Clin Periodontol
28427424	Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal. (2017 Apr 20)	Walter TJ	J Neuroinflammation
23471228	Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis. (2013 May)	Shimabukuro M	Arterioscler Thromb Vasc Biol
23114922	Prognostic value of clinical, morphologic, and immunohistochemical factors in patients with bronchiolitis obliterans-organizing pneumonia. (2013 May)	Pardo J	Hum Pathol
25351656	Establishment of a Langerhans cell histiocytosis lesion cell line with dermal dendritic cell characteristics. (2015 Jan)	Murakami I	Oncol Rep
16899487	Reduced bronchial CD4+ T-cell density in smokers with occupational asthma. (2006 Dec)	Sjaheim T	Eur Respir J
25860660	Pathological findings of saccular cerebral aneurysms-impact of subintimal fibrin deposition on aneurysm rupture. (2015 Jul)	Hokari M	Neurosurg Rev
25477344	Prevalence of nonatheromatous lesions in peripheral arterial disease. (2015 Feb)	O'Neill WC	Arterioscler Thromb Vasc Biol
28057062	Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report. (2017 Jan 3)	Ferreira JC	BMC Res Notes
24074616	Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients. (2013 Sep)	Chen YY	Chin Med Sci J
25241781	[Mechanisms of myeloid cell RelA/p65 in cigarette smoking-induced lung cancer growth in mice]. (2014 Jun)	Yao Y	Zhonghua Zhong Liu Za Zhi
12554896	Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. (2003 Feb)	Amin K	Thorax
29250688	Pulmonary Langerhans cell histiocytosis in a 26-year-old female: still a diagnostic challenge. (2017)	Ianosi ES	Rom J Morphol Embryol
11199094	Lymphocytes, chronic bronchitis and chronic obstructive pulmonary disease. (2001)	Jeffery PK	Novartis Found Symp
20472710	Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. (2010 Aug)	Roh GS	Am J Physiol Lung Cell Mol Physiol
27156912	Cadmium exposure as measured in blood in relation to macrophage density in symptomatic atherosclerotic plaques from human carotid artery. (2016 Jun)	Fagerberg B	Atherosclerosis
1359819	Increased number of alveolar macrophages expressing adhesion molecules of the leukocyte adhesion molecule family in smoking subjects. Association with cell-binding ability and superoxide anion production. (1992 Nov)	Schaberg T	Am Rev Respir Dis
15566009	[A case of pulmonary Langerhans' cell histiocytosis with liver involvement]. (2004 Oct)	Nagai S	Nihon Kokyuki Gakkai Zasshi
26546473	Smoking habits and clinical patterns can alter the inflammatory infiltrate in oral lichenoid lesions. (2016 Jan)	Alrashdan MS	Oral Surg Oral Med Oral Pathol Oral Radiol
25043641	Prognostic impact of preoperative monocyte counts in patients with resected lung adenocarcinoma. (2014 Sep)	Kumagai S	Lung Cancer
27252415	Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients. (2016 Dec 15)	Parra ER	Clin Cancer Res
15678248	Smoking increases inflammation and metalloproteinase expression in human carotid atherosclerotic plaques. (2004 Dec)	Kangavari S	J Cardiovasc Pharmacol Ther
16050471	[A case of pulmonary langerhans cell histiocytosis presenting disappearance of coalescing air wall cysts after smoking cessation]. (2005 Jul)	Okubo F	Nihon Kokyuki Gakkai Zasshi
17043800	Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males. (2007 Feb)	Bonaterra GA	J Mol Med (Berl)
19690778	Malignant fibrous histiocytoma of larynx with giant cell: case report and histological-clinical considerations. (2009)	Anghelina F	Rom J Morphol Embryol
21508219	Cocaine hijacks sigma1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS. (2011 Apr 20)	Yao H	J Neurosci
29530009	Kidney stone formers have more renal parenchymal crystals than non-stone formers, particularly in the papilla region. (2018 Mar 12)	Okada A	BMC Urol
9692098	Smoking alters the phenotype of macrophages in induced sputum. (1998 Mar)	Lensmar C	Respir Med
29437243	Melatonin attenuates smoking-induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats. (2018 May)	Li T	J Pineal Res
10188108	Plasmacytoid monocytes appear in the bronchoalveolar lavage: differences between smokers and nonsmokers. (1999 Mar)	John M	Exp Lung Res
22215599	Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. (2012 Jan 17)	Bozinovski S	Proc Natl Acad Sci U S A
16778410	Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report. (2006 Jun)	Lee JS	J Korean Med Sci
29367523	[The pathogenic role of ACPA in rheumatoid arthritis]. (2017)	Umeda N	Nihon Rinsho Meneki Gakkai Kaishi
15572382	Uric acid correlates with the severity of histopathological parameters in IgA nephropathy. (2005 Jan)	Myllymaki J	Nephrol Dial Transplant
28053911	Verruciform xanthoma in the hard palate: a case report and literature review. (2016 Dec)	Garcia AS	J Korean Assoc Oral Maxillofac Surg
9117016	Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. (1997 Mar)	O'Shaughnessy TC	Am J Respir Crit Care Med