Gene: CD69

969
AIM|BL-AC/P26|CLEC2C|EA1|GP32/28|MLR-3
CD69 molecule
protein-coding
12p13.31
Ensembl:ENSG00000110848 MIM:107273 Vega:OTTHUMG00000168481 UniprotKB:Q07108
NC_000012.12
PubMed
0   ANCO-SNPs
ND|AD
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.374e-1 (AD)  3.212e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCL50.832
CYTIP0.784
HSH2D0.781
PARP150.777
DDX60L0.77
IL150.764
RHOH0.762
EPSTI10.76
NOD20.751
SAMD90.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF835-0.406
MYADML2-0.394
HRH3-0.373
CYP46A1-0.368
FUT9-0.365
FEZF2-0.362
CHRNA4-0.354
MAGIX-0.347
HNF1A-0.346
ASPDH-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C5239344(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester inhibits the reaction [AGT protein modified form results in increased expression of CD69 protein]"24456201
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD69 mRNA17093179
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CD69 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CD69 mRNA20409345
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins results in increased expression of CD69 protein"17009048
D000602Amino Acids, Peptides, and Proteins"sodium arsenite inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of CD69 protein]"17009048
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD69 mRNA16483693
D000841AnisomycinAnisomycin results in increased expression of CD69 mRNA24247028
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD69 mRNA24449571
D001151ArsenicArsenic affects the expression of CD69 mRNA18414638
D001151ArsenicArsenic results in decreased expression of CD69 mRNA27838757
C015001arsenitearsenite results in increased methylation of CD69 promoter23974009
D001205Ascorbic AcidAscorbic Acid deficiency results in decreased expression of CD69 protein22306178
D001280AtrazineAtrazine results in decreased expression of CD69 protein25433234
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CD69 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD69 mRNA27858113
D001554BenzeneBenzene results in decreased expression of CD69 mRNA19162166
D001554BenzeneBenzene results in increased expression of CD69 mRNA21843810
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD69 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CD69 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of CD69 mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD69 mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD69 mRNA27858113
D047071beta-Glucansbeta-Glucans results in increased expression of CD69 protein17572156
C006780bisphenol Abisphenol A affects the expression of CD69 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CD69 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CD69 mRNA21601586|2424702
D000069286BortezomibBortezomib results in increased expression of CD69 mRNA20977926
D000001CalcimycinCalcimycin results in increased expression of CD69 protein25410152
D000001Calcimycin"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]"23941771
D000001CalcimycinPlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]23941771
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein23941771
D000001CalcimycinCalcimycin results in increased expression of CD69 protein25410152
C470213capsiatecapsiate analog results in decreased localization of CD69 protein12115659
D002737ChloropreneChloroprene results in decreased expression of CD69 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD69 mRNA27858113
D003033Coal TarCoal Tar results in increased expression of CD69 mRNA27858113
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of CD69 mRNA24356939
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD69 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of CD69 mRNA24356939|2522440
D016572CyclosporineCyclosporine results in increased expression of CD69 mRNA25224403
D003606DacarbazineDacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein]17973783
D003606Dacarbazine[Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 protein14669796
D003606Dacarbazine[Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]17973783
D000069439DasatinibDasatinib results in decreased expression of CD69 protein17962511
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CD69 mRNA23914054
C014347decitabinedecitabine affects the expression of CD69 mRNA17145863
D013759DronabinolDronabinol results in increased expression of CD69 mRNA15454482
D003703DemecolcineDemecolcine results in increased expression of CD69 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of CD69 mRNA22846391|2424702
D003907DexamethasoneDexamethasone results in increased expression of CD69 mRNA12782123
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of CD69 mRNA21041162|2218540
D003994BucladesineBucladesine results in decreased expression of CD69 protein25433234
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of CD69 mRNA17093179
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CD69 mRNA"23811387
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of CD69 protein"24456201
C031818enterotoxin B, staphylococcal"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in increased expression of CD69 protein"24200994
C031818enterotoxin B, staphylococcal"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C031818enterotoxin B, staphylococcal"MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C031818enterotoxin B, staphylococcal"mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C031818enterotoxin B, staphylococcal"trichostatin A inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of CD69 protein21195724
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CD69 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CD69 mRNA23649840
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Silicon Dioxide results in increased expression of CD69 protein]15790520
D006221HalothaneHalothane results in increased expression of CD69 protein21245496
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of CD69 mRNA26941288
C031927hydroquinonehydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 protein]20054000
C016517indole-3-carbinol"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
D015759IonomycinIonomycin results in increased expression of CD69 mRNA24247028
D015759Ionomycin[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein26343699
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein23134680
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD69 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD69 mRNA26941288
D001556LindaneLindane results in increased expression of CD69 mRNA24356939
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CD69 mRNA"24972896
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]22185406
D008070Lipopolysaccharideshydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 protein]20054000
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD69 mRNA22185406
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD69 protein20054000|2034823
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]22185406
D008070LipopolysaccharidesTetrachlorodibenzodioxin affects the reaction [Lipopolysaccharides results in increased expression of CD69 protein]20348231
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]"22185406
C577554MC1568"MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD69 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of CD69 mRNA29191790
D015735MifepristoneMifepristone results in increased expression of CD69 mRNA17584828
C523184mocetinostat"mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CD69 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD69 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD69 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD69 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of CD69 mRNA23811387
D009532NickelNickel results in increased expression of CD69 mRNA23195993|2558310
C029938nickel sulfatenickel sulfate results in increased expression of CD69 mRNA16780908
C025589ochratoxin Aochratoxin A results in decreased expression of CD69 mRNA24356939
D009822Oils, Volatile"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]"23941771
C000605331OTX015OTX015 inhibits the reaction [prostratin results in increased expression of CD69 protein]27067814
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD69 mRNA25729387
D010431PentoxifyllinePentoxifylline results in decreased expression of CD69 protein25433234
D010938Plant OilsPlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]23941771
C070999prostratinOTX015 inhibits the reaction [prostratin results in increased expression of CD69 protein]27067814
C070999prostratinprostratin results in increased expression of CD69 protein27067814
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of CD69 mRNA22185406
C059514resveratrolresveratrol results in increased expression of CD69 protein17088997
C059514resveratrolresveratrol results in decreased expression of CD69 protein21807089
D015474Isotretinoin[Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]17973783
D012715Sesame OilSesame Oil results in decreased expression of CD69 mRNA29191790
D012822Silicon Dioxide1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Silicon Dioxide results in increased expression of CD69 protein]15790520
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CD69 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of CD69 protein15790520
C017947sodium arsenitesodium arsenite results in increased expression of CD69 protein16275621
C017947sodium arsenite"sodium arsenite inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of CD69 protein]"17009048
C061133tamibarotenetamibarotene affects the expression of CD69 mRNA15498508
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CD69 mRNA25424538
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD69 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CD40LG protein results in increased expression of CD69 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD69 protein29107001
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD69 protein25543051
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [Lipopolysaccharides results in increased expression of CD69 protein]20348231
D013755Tetradecanoylphorbol Acetate"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]"23941771
D013755Tetradecanoylphorbol AcetatePlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein]23941771
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CD69 protein23941771
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CD69 protein12749906|1796251
D013755Tetradecanoylphorbol Acetate[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein26343699
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein23134680
D019284ThapsigarginThapsigargin results in increased expression of CD69 mRNA24247028
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CD69 mRNA22363418
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of CD69 mRNA"22185406
C056583tolmetin glucuronidetolmetin glucuronide results in increased expression of CD69 mRNA26528891
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD69 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD69 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of CD69 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of CD69 mRNA15498508
C011559tributyltintributyltin results in increased expression of CD69 mRNA29191790
D014238Trichloroacetic Acid[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein26343699
C012589trichostatin A"trichostatin A inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein]"24200994
D014635Valproic AcidValproic Acid results in increased expression of CD69 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD69 gene25560391
D014750VincristineVincristine results in increased expression of CD69 mRNA23649840
C111237vorinostatvorinostat results in increased expression of CD69 mRNA26941288
C088658zoledronic acidzoledronic acid results in increased expression of CD69 mRNA24714768
C027368zomepirac glucuronidezomepirac glucuronide results in increased expression of CD69 mRNA26528891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS8340758  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16525420  25416956  
GO:0030246carbohydrate binding-IEA-  
GO:0042803protein homodimerization activity-IMP11101293  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0035690cellular response to drug-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS8340758  
GO:0009897external side of plasma membrane-IEA-  
GO:0032991protein-containing complex-IMP11101293  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23851003Combustible and non-combustible tobacco product preparations differentially regulate human peripheral blood mononuclear cell functions. (2013 Sep)Arimilli SToxicol In Vitro
20605406Changes in peripheral blood lymphocyte phenotypes distribution in patients with oral cancer/oral leukoplakia in Taiwan. (2010 Aug)Lee JJInt J Oral Maxillofac Surg
19002140Differential effects on T-cell function following exposure to serum from schizophrenia smokers. (2010 Apr)Herberth MMol Psychiatry
19711824The relationship between cell surface markers, cytokines, ageing, and cigarette smoking. (2009)Horvathova MBratisl Lek Listy
12749906Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase. (2003 Jun)McCue JMMol Immunol
29662662Health effects of a forest environment on natural killer cells in humans: an observational pilot study. (2018 Mar 27)Tsao TMOncotarget
22652413Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease. (2013 Feb)Mikko MImmunobiology
17184930Relationship between cumulative effects of smoking and memory CD4+ T lymphocyte subpopulations. (2007 Jul)Nakata AAddict Behav
22955940Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. Relationship to clinical risk factors. (2012 Nov)Sagan AThromb Haemost
29514648Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD. (2018 Mar 8)Yang MRespir Res
20863413Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD. (2010 Sep 24)Roos-Engstrand ERespir Res
9660319Activated lymphocytes (CD25+ CD69+ cells) and decreased CD19+ cells in well-nourished chronic alcoholics without ethanol-related diseases. (1998 Jun)Sacanella EAlcohol Clin Exp Res
21684213Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. (2011 Sep)Hogan AEClin Immunol
10542990A comparison of the expression of lymphocyte activation markers in blood, bronchial biopsies and bronchoalveolar lavage: evidence for an enrichment of activated T lymphocytes in the bronchoalveolar space. (1999 Aug)Ekberg-Jansson ARespir Med
20427767Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. (2010 Jun 1)Freeman CMJ Immunol
26412231Differences in oral habit and lymphocyte subpopulation affect malignant transformation of patients with oral precancer. (2016 Apr)Yeh CYJ Formos Med Assoc