Gene: UBE3C

9690
HECTH2
ubiquitin protein ligase E3C
protein-coding
7q36.3
Ensembl:ENSG00000009335 MIM:614454 Vega:OTTHUMG00000157239 UniprotKB:Q15386
NC_000007.14
PubMed
0   ANCO-SNPs
OD|CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.871e-1 (AD)  4.296e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RALGAPB0.966
ATP2A20.959
POLR2B0.958
WDR820.956
LARP10.955
AREL10.955
SLC35E10.954
CIAO10.954
CLTC0.954
UBFD10.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.603
OR4F29-0.559
CSAG1-0.387
MYL3-0.382
MTRNR2L6-0.38
MTRNR2L10-0.364
MTRNR2L9-0.362
HEY2-0.347
SH2D1A-0.335
COPZ2-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UBE3C mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of UBE3C mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of UBE3C mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of UBE3C mRNA22230336
D001151ArsenicArsenic affects the methylation of UBE3C gene25304211
D001152ArsenicalsArsenicals results in increased methylation of UBE3C promoter26039340
D001241AspirinUBE3C polymorphism affects the susceptibility to Aspirin20934631
D001280AtrazineAtrazine results in decreased expression of UBE3C mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UBE3C mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of UBE3C mRNA21179406
C006780bisphenol Abisphenol A affects the expression of UBE3C mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of UBE3C mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of UBE3C mRNA29097150
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of UBE3C mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UBE3C mRNA23741332
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UBE3C mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of UBE3C mRNA21356098
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UBE3C mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of UBE3C protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE3C mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE3C mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE3C mRNA29097150
D008727MethotrexateMethotrexate results in increased expression of UBE3C mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UBE3C mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UBE3C mRNA"25554681
C051752nefazodonenefazodone results in increased expression of UBE3C mRNA24136188
D009532NickelNickel results in increased expression of UBE3C mRNA25583101
C012655nimesulidenimesulide results in increased expression of UBE3C mRNA24136188
D052638Particulate MatterParticulate Matter results in increased expression of UBE3C mRNA24769257
C006253pirinixic acidpirinixic acid results in decreased expression of UBE3C mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of UBE3C mRNA18301758
D011794QuercetinQuercetin results in increased expression of UBE3C mRNA21356098
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of UBE3C mRNA19429434
D012402RotenoneRotenone results in decreased expression of UBE3C mRNA23186747
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of UBE3C mRNA23806026
C009277sodium arsenatesodium arsenate results in decreased expression of UBE3C mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE3C mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE3C mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE3C mRNA22298810
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of UBE3C mRNA"21356098
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of UBE3C mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of UBE3C mRNA23179753|2800136
D012256RiboflavinRiboflavin results in increased expression of UBE3C mRNA21356098

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA11278995  
GO:0005515protein binding-IPI11278995  12692129  25416956  
GO:0061631ubiquitin conjugating enzyme activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0000209protein polyubiquitination-IDA11278995  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IEA-  
GO:0005622intracellular-IC11278995  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21849985A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (2011 Nov)Yang BZNeuropsychopharmacology