Gene: EDEM1

9695
EDEM
ER degradation enhancing alpha-mannosidase like protein 1
protein-coding
3p26.1
Ensembl:ENSG00000134109 MIM:607673 Vega:OTTHUMG00000154896 UniprotKB:Q92611
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.881e-1 (AD)  7.160e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16505233chr3:5239311EDEM15.690e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATXN70.888
NUP1530.886
RPRD1B0.885
GAPVD10.884
LARP4B0.882
ZNF4400.882
ZNF5500.881
YME1L10.879
IREB20.878
ZMYM60.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.529
OR4F29-0.483
KLRC2-0.262
S100A1-0.245
CTNNA3-0.231
MTRNR2L6-0.226
ANXA13-0.226
MTRNR2L9-0.225
MTRNR2L10-0.223
TNFRSF13B-0.221

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of EDEM1 mRNA23883479
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of EDEM1 mRNA]23883479
C0757734-phenylbutyric acid4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of EDEM1 mRNA28698385
D000082AcetaminophenAcetaminophen affects the expression of EDEM1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EDEM1 mRNA19770486
C006632arsenic trioxidearsenic trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of EDEM1 mRNA]23883479
C006632arsenic trioxidearsenic trioxide results in increased expression of EDEM1 mRNA23883479
D001280AtrazineAtrazine results in increased expression of EDEM1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of EDEM1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of EDEM1 mRNA22323515
C004456beauvericinbeauvericin results in increased expression of EDEM1 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EDEM1 mRNA21569818
C006780bisphenol Abisphenol A results in increased expression of EDEM1 mRNA27571134|2909715
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDEM1 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of EDEM1 mRNA21601586
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of EDEM1 mRNA22434021
C032688boric acidboric acid results in increased expression of EDEM1 mRNA27587023
D002065BuspironeBuspirone results in increased expression of EDEM1 mRNA24136188
D002104CadmiumCadmium results in increased expression of EDEM1 mRNA26187450
D002220CarbamazepineCarbamazepine affects the expression of EDEM1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EDEM1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of EDEM1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of EDEM1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of EDEM1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of EDEM1 mRNA25270620
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EDEM1 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDEM1 mRNA28628672
D004008DiclofenacDiclofenac results in increased expression of EDEM1 mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of EDEM1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of EDEM1 mRNA19030233|2803146
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of EDEM1 mRNA]19030233
D004147DioxinsDioxins affects the expression of EDEM1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EDEM1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EDEM1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EDEM1 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of EDEM1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of EDEM1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of EDEM1 mRNA24136188
D005944GlucosamineGlucosamine results in decreased expression of EDEM1 mRNA17178593
D005947GlucoseGlucose results in decreased expression of EDEM1 mRNA17178593
D017313FenretinideFenretinide results in decreased expression of EDEM1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDEM1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EDEM1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDEM1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of EDEM1 mRNA21335049|2182321
C045463leflunomideleflunomide results in increased expression of EDEM1 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of EDEM1 mRNA24136188
D008627Mercuric ChlorideMercuric Chloride affects the expression of EDEM1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EDEM1 mRNA23458150
D008777MethyltestosteroneMethyltestosterone results in decreased expression of EDEM1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EDEM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EDEM1 mRNA"25554681
D019829NevirapineNevirapine results in increased expression of EDEM1 mRNA23947594
D009532NickelNickel results in increased expression of EDEM1 mRNA25583101
D000073878Palm OilPalm Oil results in decreased expression of EDEM1 mRNA18042831
D010269ParaquatParaquat results in increased expression of EDEM1 protein19735704
D010269Paraquatsalubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein]19735704
D010433PentylenetetrazolePentylenetetrazole affects the expression of EDEM1 mRNA21503142
D010795Phthalic AcidsPhthalic Acids results in decreased expression of EDEM1 mRNA21061450
C014153pirimiphos methylpirimiphos methyl results in decreased expression of EDEM1 mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of EDEM1 mRNA23811191
C045950propiconazolepropiconazole results in increased expression of EDEM1 mRNA21278054
C031280pyrazolepyrazole results in increased expression of EDEM1 mRNA17945193
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of EDEM1 mRNA]19030233
C496827salubrinalsalubrinal inhibits the reaction [Paraquat results in increased expression of EDEM1 protein]19735704
D012999SomanSoman results in increased expression of EDEM1 mRNA19281266
C559087SR 1078SR 1078 results in increased expression of EDEM1 mRNA28698385
D013311StreptozocinStreptozocin results in increased expression of EDEM1 mRNA25905778
D014284TriiodothyronineTriiodothyronine results in increased expression of EDEM1 mRNA22281776
D016559TacrolimusTacrolimus results in increased expression of EDEM1 mRNA25270620
D013629TamoxifenTamoxifen affects the expression of EDEM1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EDEM1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of EDEM1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EDEM1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EDEM1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EDEM1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EDEM1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of EDEM1 mRNA22378314|2758702
D013853ThioacetamideThioacetamide results in decreased expression of EDEM1 mRNA23411599
D014212TretinoinTretinoin results in increased expression of EDEM1 mRNA22498432
C012589trichostatin Atrichostatin A results in increased expression of EDEM1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EDEM1 mRNA19042947
D014415TunicamycinTunicamycin results in increased expression of EDEM1 mRNA22378314|2431263
D014415TunicamycinTunicamycin results in increased expression of EDEM1 protein19735704
D014415TunicamycinTunicamycin results in increased expression of EDEM1 mRNA22414386
C406224valdecoxibvaldecoxib results in decreased expression of EDEM1 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of EDEM1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of EDEM1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of EDEM1 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004571mannosyl-oligosaccharide 1,2-alpha-mannosidase activityNOTIDA12610306  
GO:0004571mannosyl-oligosaccharide 1,2-alpha-mannosidase activity-IMP25092655  
GO:0004571mannosyl-oligosaccharide 1,2-alpha-mannosidase activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16449189  19524542  19934218  
GO:0051787misfolded protein binding-IDA19524542  
GO ID GO Term Qualifier Evidence PubMed
GO:0030433ubiquitin-dependent ERAD pathway-ISS-  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0036510trimming of terminal mannose on C branch-IEA-  
GO:0097466ubiquitin-dependent glycoprotein ERAD pathway-IMP21062743  25092655  
GO:1904154positive regulation of retrograde protein transport, ER to cytosol-IGI24200403  
GO:1904154positive regulation of retrograde protein transport, ER to cytosol-IMP24200403  
GO:1904382mannose trimming involved in glycoprotein ERAD pathway-IMP25092655  
GO:1904382mannose trimming involved in glycoprotein ERAD pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA24200403  
GO:0005783endoplasmic reticulum-IMP21062743  
GO:0016235aggresome-IDA-  
GO:0030176integral component of endoplasmic reticulum membrane-ISS-  
GO:0044322endoplasmic reticulum quality control compartment-TAS-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycleTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-901032ER Quality Control Compartment (ERQC)TAS
R-HSA-901042Calnexin/calreticulin cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24037343Identification of genes promoting skin youthfulness by genome-wide association study. (2014 Mar)Chang ALSJ Invest Dermatol
28070146Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. (2016)Geraghty PMediators Inflamm