Gene: ESPL1

9700
ESP1|SEPA
extra spindle pole bodies like 1, separase
protein-coding
12q13.13
Ensembl:ENSG00000135476 MIM:604143 Vega:OTTHUMG00000169674 UniprotKB:Q14674
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.104e-1 (AD)  8.512e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPN70.579
UBE2C0.544
TMEM1730.528
SMAGP0.509
ARHGEF190.502
COL1A10.501
ASF1B0.499
CCNB20.497
STK100.497
AQP100.493

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAH-0.28
PVALB-0.271
KIT-0.253
HAPLN4-0.251
KCNC2-0.247
MOXD1-0.245
MOGAT3-0.241
SHD-0.24
ANK1-0.234
HPSE2-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ESPL1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ESPL1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ESPL1 mRNA"19167446
C4408502,4,3',5'-tetramethoxystilbene"2,4,3',5'-tetramethoxystilbene results in increased expression of ESPL1 mRNA"20490654
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ESPL1 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of ESPL1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ESPL1 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of ESPL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ESPL1 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ESPL1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ESPL1 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of ESPL1 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of ESPL1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of ESPL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ESPL1 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ESPL1 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of ESPL1 mRNA18310284|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of ESPL1 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of ESPL1 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of ESPL1 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of ESPL1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of ESPL1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ESPL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ESPL1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ESPL1 mRNA26079696
D002509CephaloridineCephaloridine results in decreased expression of ESPL1 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ESPL1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ESPL1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of ESPL1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ESPL1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ESPL1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ESPL1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of ESPL1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ESPL1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in decreased expression of ESPL1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ESPL1 mRNA]20032058
D003976DiazinonDiazinon affects the expression of ESPL1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ESPL1 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ESPL1 mRNA28302478
D004026DieldrinDieldrin affects the expression of ESPL1 mRNA22546817
D002117CalcitriolCalcitriol results in decreased expression of ESPL1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of ESPL1 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of ESPL1 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ESPL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESPL1 mRNA17942748
D005472FluorouracilESPL1 protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ESPL1 mRNA20938992
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of ESPL1 mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of ESPL1 mRNA19016759
C039281furanfuran results in increased expression of ESPL1 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of ESPL1 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of ESPL1 mRNA26191083
D007213IndomethacinIndomethacin results in decreased expression of ESPL1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ESPL1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of ESPL1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ESPL1 mRNA24796395
D007840LatexLatex analog results in increased expression of ESPL1 mRNA24768652
D007854LeadLead affects the expression of ESPL1 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of ESPL1 mRNA28988120
D008154LucanthoneLucanthone results in decreased expression of ESPL1 mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ESPL1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ESPL1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ESPL1 mRNA26011545
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ESPL1 protein24625837
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ESPL1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ESPL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ESPL1 mRNA"25554681
D009532NickelNickel results in increased expression of ESPL1 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of ESPL1 mRNA22546817
C025589ochratoxin Aochratoxin A results in increased expression of ESPL1 mRNA19237604
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ESPL1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ESPL1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of ESPL1 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ESPL1 mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of ESPL1 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of ESPL1 mRNA23091169
D048789PhytoestrogensPhytoestrogens results in increased expression of ESPL1 mRNA18310284
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ESPL1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ESPL1 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of ESPL1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ESPL1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ESPL1 mRNA19167446
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of ESPL1 mRNA19016759
C017947sodium arsenitesodium arsenite results in increased expression of ESPL1 protein16338954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of ESPL1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ESPL1 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ESPL1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ESPL1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ESPL1 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ESPL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESPL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ESPL1 mRNA21496263
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ESPL1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ESPL1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of ESPL1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ESPL1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ESPL1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ESPL1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ESPL1 mRNA19042947
C001899triptolidetriptolide results in increased expression of ESPL1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ESPL1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ESPL1 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of ESPL1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of ESPL1 gene29154799
C029297vinylidene chloridevinylidene chloride results in increased expression of ESPL1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-NAS12672959  
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0005515protein binding-IPI12194817  12672959  
GO:0008234cysteine-type peptidase activity-NAS12672959  
GO:0008234cysteine-type peptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000070mitotic sister chromatid segregation-IMP12672959  
GO:0000212meiotic spindle organization-IEA-  
GO:0000281mitotic cytokinesis-NAS11509732  
GO:0006508proteolysis-IEA-  
GO:0006915apoptotic process-TAS11875078  
GO:0040001establishment of mitotic spindle localization-NAS12672959  
GO:0045143homologous chromosome segregation-IEA-  
GO:0045842positive regulation of mitotic metaphase/anaphase transition-NAS12672959  
GO:0045875negative regulation of sister chromatid cohesion-NAS12194817  
GO:0051307meiotic chromosome separation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA12672959  
GO:0005829cytosol-TAS-  
GO:0072686mitotic spindle-IBA21873635  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29328493Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers. (2018 Mar)He XOncol Rep