Gene: CD72

971
CD72b|LYB2
CD72 molecule
protein-coding
9p13.3
Ensembl:ENSG00000137101 MIM:107272 Vega:OTTHUMG00000019870 UniprotKB:P21854
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.396e-1 (AD)  9.502e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14016344chr9:35616726CD722.070e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZMYND150.755
CLEC2D0.754
NSUN70.739
PATL20.739
MAP3K80.733
TLR80.733
ALPK10.73
CD1D0.725
DAPP10.712
LILRB20.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNG1-0.455
WNT7A-0.431
ANKRD34A-0.428
KCNJ6-0.424
PTPRR-0.421
HAS1-0.42
SLC1A6-0.418
MARCH4-0.414
NNAT-0.412
HNF1A-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CD72 3' UTR28843141
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CD72 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD72 mRNA24449571
D001151ArsenicArsenic affects the methylation of CD72 gene25304211
D001280AtrazineAtrazine results in increased expression of CD72 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD72 mRNA21569818
C006780bisphenol Abisphenol A affects the expression of CD72 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CD72 promoter22457795
D002509CephaloridineCephaloridine results in increased expression of CD72 mRNA18500788
D002737ChloropreneChloroprene results in decreased expression of CD72 mRNA23125180
D003907DexamethasoneDexamethasone results in increased expression of CD72 mRNA21041162
D016264Dextran SulfateDextran Sulfate results in increased expression of CD72 mRNA23894361
D004041Dietary FatsDietary Fats results in decreased expression of CD72 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD72 mRNA21041162
D004397FonofosFonofos results in increased methylation of CD72 promoter22847954
C039281furanfuran results in increased expression of CD72 mRNA27387713
C412815GW 4064GW 4064 results in increased expression of CD72 mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD72 mRNA22904298
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CD72 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CD72 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CD72 mRNA19812364
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CD72 3' UTR28843141
C507134ON 01910ON 01910 results in decreased expression of CD72 mRNA22351695
D010100OxygenOxygen deficiency results in increased expression of CD72 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of CD72 mRNA20880076
D010278ParathionParathion results in increased methylation of CD72 promoter22847954
C006253pirinixic acidpirinixic acid results in decreased expression of CD72 mRNA20813756
C059514resveratrolresveratrol results in decreased expression of CD72 mRNA20730501
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CD72 mRNA25895662
D053260SootSoot results in increased expression of CD72 mRNA26551751
C012568terbufosterbufos results in increased methylation of CD72 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD72 mRNA26290441
C009495titanium dioxidetitanium dioxide results in increased expression of CD72 mRNA19695317
C009495titanium dioxidetitanium dioxide results in decreased expression of CD72 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of CD72 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD72 mRNA20133372
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CD72 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CD72 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS1711157  
GO:0005102signaling receptor binding-TAS1711157  
GO:0005515protein binding-IPI1711157  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS1711157  
GO:0007165signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA1711157  
KEGG ID KEGG Term
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-416700Other semaphorin interactionsTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27814717Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. (2016 Nov 5)Busch RRespir Res