Gene: CD74

972
DHLAG|HLADG|II|Ia-GAMMA
CD74 molecule
protein-coding
5q33.1
Ensembl:ENSG00000019582 MIM:142790 Vega:OTTHUMG00000163559 UniprotKB:P04233
NG_029730.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.745e-2 (AD)  5.724e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-DRA0.964
HLA-DPA10.961
TYROBP0.933
LAPTM50.929
AIF10.922
C30.916
C1QA0.913
ITGB20.909
C1QC0.909
FCER1G0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.36
ST6GAL2-0.35
HES5-0.349
MARCH4-0.346
CPLX3-0.327
ADRA1D-0.327
FRMPD2-0.325
ZSCAN1-0.322
WNT7A-0.32
ABCC12-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CD74 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CD74 mRNA"25614096
C492600(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of CD74 mRNA"19176366
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CD74 mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CD74 mRNA"20206263
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of CD74 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of CD74 mRNA]28655636
C0194992-nitrofluorene2-nitrofluorene results in increased expression of CD74 mRNA14600272
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CD74 mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD74 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD74 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD74 mRNA"27188386
C496492abrineabrine affects the expression of CD74 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of CD74 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CD74 mRNA15606129|1756273
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CD74 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CD74 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of CD74 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of CD74 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD74 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CD74 mRNA21298039
D000639AmitriptylineAmitriptyline results in increased expression of CD74 mRNA22341215
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD74 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD74 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CD74 mRNA20458559
C015001arsenitearsenite results in increased methylation of CD74 promoter23974009
D001241AspirinAspirin results in decreased expression of CD74 mRNA15928584
D001554BenzeneBenzene results in decreased expression of CD74 mRNA17905399
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CD74 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CD74 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD74 mRNA21569818
C068337bergamottinbergamottin results in decreased expression of CD74 mRNA18818744
C095105bexarotenebexarotene results in increased expression of CD74 mRNA16648578
C452139BIRB 796BIRB 796 results in decreased expression of CD74 mRNA21328587
C006780bisphenol Abisphenol A results in increased expression of CD74 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CD74 mRNA22079614
D016642BupropionBupropion affects the expression of CD74 mRNA25811541
D002065BuspironeBuspirone results in decreased expression of CD74 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CD74 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CD74 mRNA18804290
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD74 mRNA]18038451
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of CD74 mRNA19395590
D002922CiguatoxinsCiguatoxins affects the expression of CD74 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CD74 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CD74 mRNA]17585979
D003042CocaineCocaine affects the expression of CD74 mRNA20187946
D003300CopperCopper results in decreased expression of CD74 mRNA22465980
D003471CuprizoneCuprizone results in increased expression of CD74 mRNA26577399|2752363
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD74 mRNA15331540
D016572CyclosporineCyclosporine results in decreased expression of CD74 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CD74 mRNA23958496
D003907DexamethasoneDexamethasone results in increased expression of CD74 mRNA21041162
D016264Dextran SulfateDextran Sulfate results in increased expression of CD74 mRNA23894361
D004041Dietary FatsDietary Fats results in decreased expression of CD74 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CD74 mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of CD74 mRNA27405655
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD74 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CD74 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD74 mRNA21041162
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of CD74 mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CD74 mRNA14600272|2538013
D004237DiuronDiuron results in increased expression of CD74 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of CD74 mRNA25896364
D004317DoxorubicinDoxorubicin results in decreased expression of CD74 mRNA19915844
C108024emamectin benzoateemamectin benzoate results in increased expression of CD74 mRNA18786259
C118739entinostatentinostat results in increased expression of CD74 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CD74 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CD74 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD74 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD74 mRNA12655037|1735126
C000499ferric oxideferric oxide analog results in decreased expression of CD74 mRNA25086211
C043055gallium arsenidegallium arsenide results in increased cleavage of CD74 protein12583989
D019833GenisteinGenistein results in decreased expression of CD74 mRNA24967385
D005839GentamicinsGentamicins results in increased expression of CD74 mRNA22061828
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of CD74 mRNA15159207
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of CD74 mRNA26941288
C505097IMMU-110IMMU-110 binds to CD74 protein16033844
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD74 mRNA25613284
D007501IronIron deficiency results in decreased expression of CD74 mRNA20368581
D007545IsoproterenolIsoproterenol results in decreased expression of CD74 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD74 mRNA26941288
D007854LeadLead results in decreased expression of CD74 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CD74 mRNA"24972896
D019808LosartanLosartan results in decreased expression of CD74 mRNA15100363
D047311LuteolinLuteolin results in decreased expression of CD74 mRNA18818744
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CD74 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride affects the expression of CD74 mRNA20353558
C083079N-(3-nitratopivaloyl)cysteine ethyl esterN-(3-nitratopivaloyl)cysteine ethyl ester results in decreased expression of CD74 protein11046123
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CD74 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CD74 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CD74 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CD74 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of CD74 mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of CD74 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of CD74 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of CD74 mRNA19716841
C008661nobiletinnobiletin results in decreased expression of CD74 mRNA18818744
C025589ochratoxin Aochratoxin A results in increased expression of CD74 mRNA23358140
C018620oleoresinsoleoresins results in increased expression of CD74 mRNA20008804
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD74 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of CD74 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD74 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CD74 mRNA26272509
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of CD74 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of CD74 mRNA17987463|2865563
D052638Particulate Matter[CD74 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of CD74 mRNA21222557|2122255
C539933pevonedistatpevonedistat affects the expression of CD74 mRNA24634471
D010634PhenobarbitalPhenobarbital results in increased expression of CD74 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD74 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CD74 mRNA15375163|1742611
C006253pirinixic acidpirinixic acid results in decreased expression of CD74 mRNA12832660|1916217
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CD74 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CD74 mRNA19162173
D011435Propyl GallatePropyl Gallate affects the expression of CD74 mRNA18539377
D011794QuercetinQuercetin results in decreased expression of CD74 mRNA18818744
D011794QuercetinQuercetin results in increased expression of CD74 mRNA16455785
C012526quercitrinquercitrin affects the expression of CD74 mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CD74 mRNA16079270
C059514resveratrolresveratrol results in increased expression of CD74 protein25505154
D012643SeleniumSelenium results in increased expression of CD74 mRNA19244175
D012834SilverSilver results in increased expression of CD74 mRNA27131904
D012906SmokeSmoke affects the expression of CD74 mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of CD74 mRNA12634122|2271453
C017947sodium arsenitesodium arsenite results in increased expression of CD74 mRNA16322246
C016104sodium bichromatesodium bichromate results in decreased expression of CD74 mRNA22155349
C025399sodium tungstate(VI)sodium tungstate(VI) results in increased expression of CD74 mRNA26164860
C115703SP 5186SP 5186 results in decreased expression of CD74 protein11046123
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CD74 mRNA26378955
C016766sulforafansulforafan results in decreased expression of CD74 mRNA26833863
D016559TacrolimusTacrolimus results in increased expression of CD74 mRNA23958496
C061133tamibarotenetamibarotene results in increased expression of CD74 mRNA17229644
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD74 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD74 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD74 mRNA26377647|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD74 mRNA21041162|2386450
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD74 mRNA20959002
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD74 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD74 mRNA28943392
C009495titanium dioxidetitanium dioxide results in decreased expression of CD74 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of CD74 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CD74 mRNA28111298
D014050TolueneToluene results in decreased expression of CD74 mRNA22166486
D014050TolueneToluene results in increased expression of CD74 mRNA22166486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD74 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD74 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CD74 mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of CD74 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of CD74 mRNA24935251|2718838
D014295TrimethoprimTrimethoprim affects the expression of CD74 mRNA25811541
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CD74 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CD74 mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of CD74 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of CD74 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CD74 mRNA23179753
D014640VancomycinVancomycin results in decreased expression of CD74 mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of CD74 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CD74 mRNA17987463|2865563
D001335Vehicle Emissions[CD74 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of CD74 mRNA21222557|2122255
C025643vinclozolinvinclozolin affects the expression of CD74 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of CD74 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of CD74 mRNA20829426
C111237vorinostatvorinostat results in increased expression of CD74 mRNA27188386
C111237vorinostatvorinostat results in increased expression of CD74 mRNA26941288
D019287Zinc SulfateZinc Sulfate results in decreased expression of CD74 mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of CD74 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IPI19849849  
GO:0004896cytokine receptor activity-IDA17045821  
GO:0005515protein binding-IPI16242130  17357109  19665027  24428437  25241761  29190904  
GO:0019955cytokine binding-IPI12782713  17567581  
GO:0023026MHC class II protein complex binding-IDA1448172  
GO:0035718macrophage migration inhibitory factor binding-IPI17045821  
GO:0042289MHC class II protein binding-ISS-  
GO:0042289MHC class II protein binding-NAS10981873  
GO:0042609CD4 receptor binding-IPI24942581  
GO:0042658MHC class II protein binding, via antigen binding groove-IDA7477400  
GO:0042802identical protein binding-TAS12782713  
GO:0044183protein binding involved in protein folding-IDA7477400  
GO:0050998nitric-oxide synthase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0001516prostaglandin biosynthetic process-IDA12782713  
GO:0001934positive regulation of protein phosphorylation-IDA24942581  
GO:0001961positive regulation of cytokine-mediated signaling pathway-IMP12782713  
GO:0002606positive regulation of dendritic cell antigen processing and presentation-IEA-  
GO:0002792negative regulation of peptide secretion-IDA19849849  
GO:0002830positive regulation of type 2 immune response-IEA-  
GO:0002906negative regulation of mature B cell apoptotic process-IEA-  
GO:0006886intracellular protein transport-ISS-  
GO:0006952defense response-IEA-  
GO:0007165signal transduction-IDA12782713  
GO:0008283cell proliferation-IDA12782713  
GO:0016064immunoglobulin mediated immune response-ISS-  
GO:0019883antigen processing and presentation of endogenous antigen-NAS10981873  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0030890positive regulation of B cell proliferation-IMP12782713  
GO:0033674positive regulation of kinase activity-IDA24942581  
GO:0035691macrophage migration inhibitory factor signaling pathway-IEA-  
GO:0043030regulation of macrophage activation-NAS12782713  
GO:0043066negative regulation of apoptotic process-IDA12782713  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA24942581  
GO:0043410positive regulation of MAPK cascade-IDA24942581  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IDA17045821  
GO:0045058T cell selection-NAS10981873  
GO:0045059positive thymic T cell selection-IEA-  
GO:0045060negative thymic T cell selection-IEA-  
GO:0045581negative regulation of T cell differentiation-IEA-  
GO:0045582positive regulation of T cell differentiation-IEA-  
GO:0045657positive regulation of monocyte differentiation-IDA24942581  
GO:0045893positive regulation of transcription, DNA-templated-IDA24942581  
GO:0046598positive regulation of viral entry into host cell-IDA24942581  
GO:0048146positive regulation of fibroblast proliferation-IMP12782713  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA17045821  
GO:0050900leukocyte migration-TAS-  
GO:0051085chaperone cofactor-dependent protein refolding-IEA-  
GO:0051290protein heterotetramerization-IDA24942581  
GO:0060907positive regulation of macrophage cytokine production-ISS-  
GO:0065003protein-containing complex assembly-ISS-  
GO:0070206protein trimerization-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA17045821  24942581  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP12782713  
GO:0090023positive regulation of neutrophil chemotaxis-ISS-  
GO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IMP17045821  
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005622intracellular-TAS12782713  
GO:0005765lysosomal membrane-TAS-  
GO:0005771multivesicular body-IEA-  
GO:0005773vacuole-IDA19849849  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-IDA17045821  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IDA12782713  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0035692macrophage migration inhibitory factor receptor complex-IDA17045821  
GO:0035693NOS2-CD74 complex-IEA-  
GO:0042613MHC class II protein complexcolocalizes_withISS-  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA20458337  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04612Antigen processing and presentation
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-2132295MHC class II antigen presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26705279[Detection of ALK, ROS1 and RET fusion genes in non-small cell lung cancer patients and its clinicopathologic correlation]. (2015 Sep)Zhong SZhonghua Bing Li Xue Za Zhi
25567305[Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. (2014 Oct)Cheng HZhonghua Zhong Liu Za Zhi
26200269Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. (2015 Aug)Shim HSJ Thorac Oncol
23877438CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013 Oct)Matsuura SOncol Rep
23788756The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma. (2013 Sep)Kim HRAnn Oncol
25567908Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)Drilon AClin Cancer Res