Gene info: ID 9723

Gene: SEMA3E

GENE ID: 9723

Synonyms: M-SEMAH|M-SemaK|SEMAH|coll-5

Description: semaphorin 3E

Gene type: protein-coding

Location: 7q21.11

dbXrefs: Ensembl:ENSG00000170381 MIM:608166 Vega:OTTHUMG00000154693 UniprotKB:O15041

RefSeq: NG_021242.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.280e-1 (AD) 6.039e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2247219	chr7:83438154 (GRCh38.p7)	T>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07449753	chr7:83057120	SEMA3E	Gene body	5.573e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DACH1	0.842
FOXP2	0.836
MCTP2	0.83
THEMIS	0.82
CHN2	0.81
TNIP3	0.801
FILIP1	0.796
NPFFR2	0.794
CYP26A1	0.778
GRIK3	0.769

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MSX1	-0.481
ZIC2	-0.45
TFAP2C	-0.446
ASB4	-0.437
OAF	-0.432
ENDOU	-0.416
NR2E1	-0.412
ZIC5	-0.41
EMX2	-0.408
IMPA2	-0.408

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SEMA3E mRNA	19933214
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SEMA3E mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SEMA3E mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SEMA3E gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of SEMA3E mRNA	21757418
D001280	Atrazine	Atrazine results in decreased expression of SEMA3E mRNA	25929836
C487081	belinostat	belinostat results in increased expression of SEMA3E mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of SEMA3E mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased methylation of SEMA3E promoter	28329817
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SEMA3E mRNA	23735875
C006780	bisphenol A	bisphenol A results in decreased expression of SEMA3E mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SEMA3E gene	28505145
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA3E gene	20938992
D003042	Cocaine	Cocaine affects the expression of SEMA3E mRNA	15691709
D016572	Cyclosporine	Cyclosporine results in decreased expression of SEMA3E mRNA	20106945
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SEMA3E mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SEMA3E mRNA	27392435
C118739	entinostat	entinostat results in increased expression of SEMA3E mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
D005485	Flutamide	Flutamide results in decreased expression of SEMA3E mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA3E gene	20938992
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SEMA3E mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of SEMA3E mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SEMA3E mRNA	23430699\|2479639
C008261	lead acetate	lead acetate results in increased expression of SEMA3E mRNA	25270620
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SEMA3E mRNA	21641980
C042720	mercuric bromide	mercuric bromide results in increased expression of SEMA3E mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA3E gene	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SEMA3E mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of SEMA3E mRNA	24810058
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SEMA3E mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of SEMA3E mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SEMA3E mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SEMA3E mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of SEMA3E mRNA	24768652\|2558310
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SEMA3E mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of SEMA3E mRNA	26705709
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SEMA3E mRNA	28511854
D010634	Phenobarbital	Phenobarbital affects the expression of SEMA3E mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SEMA3E mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SEMA3E mRNA	19710929
C017947	sodium arsenite	sodium arsenite affects the methylation of SEMA3E gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of SEMA3E mRNA	17879257
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SEMA3E mRNA	21641980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SEMA3E mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SEMA3E mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SEMA3E mRNA	19770486
C009495	titanium dioxide	titanium dioxide results in decreased expression of SEMA3E mRNA	23557971\|2776080
D014118	Toxins, Biological	"Toxins, Biological affects the expression of SEMA3E mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of SEMA3E mRNA	16604517
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of SEMA3E gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SEMA3E mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SEMA3E mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SEMA3E mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SEMA3E gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SEMA3E mRNA	26682919
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3E mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of SEMA3E mRNA	26272509
D015032	Zinc	Zinc deficiency results in increased expression of SEMA3E mRNA	22171008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	17318185
GO:0030215	semaphorin receptor binding	-	IBA	21873635
GO:0038191	neuropilin binding	-	IBA	21873635
GO:0045499	chemorepellent activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001569	branching involved in blood vessel morphogenesis	-	ISS	-
GO:0001755	neural crest cell migration	-	IBA	21873635
GO:0001953	negative regulation of cell-matrix adhesion	-	ISS	-
GO:0002040	sprouting angiogenesis	-	ISS	-
GO:0007399	nervous system development	-	IEA	-
GO:0008360	regulation of cell shape	-	ISS	-
GO:0016525	negative regulation of angiogenesis	-	ISS	-
GO:0030154	cell differentiation	-	IEA	-
GO:0030335	positive regulation of cell migration	-	IBA	21873635
GO:0048843	negative regulation of axon extension involved in axon guidance	-	IBA	21873635
GO:0050808	synapse organization	-	ISS	-
GO:0050919	negative chemotaxis	-	IBA	21873635
GO:0071526	semaphorin-plexin signaling pathway	-	IBA	21873635
GO:0071526	semaphorin-plexin signaling pathway	-	ISS	-
GO:2000249	regulation of actin cytoskeleton reorganization	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-416700	Other semaphorin interactions	TAS
R-HSA-422475	Axon guidance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal