Gene: CD79A

973
IGA|MB-1
CD79a molecule
protein-coding
19q13.2
Ensembl:ENSG00000105369 MIM:112205 Vega:OTTHUMG00000182678 UniprotKB:P11912
NG_009619.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.683e-1 (AD)  4.904e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUAK20.477
MS4A10.468
BAZ1A0.466
TMEM150B0.451
IL2RG0.444
LRRC690.444
DTX20.441
GNLY0.44
BEST30.437
LIMD10.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH8-0.367
CBLN4-0.354
ESRRG-0.349
FAM19A2-0.341
SLC7A4-0.34
NDST3-0.338
ST6GALNAC5-0.336
MYOZ3-0.336
SLC17A6-0.336
UBXN10-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CD79A mRNA22230336
C032311aluminum fluoridealuminum fluoride results in increased phosphorylation of CD79A protein8559152
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CD79A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD79A mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CD79A mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of CD79A mRNA20977926
D002330CarmustineCarmustine results in decreased expression of CD79A mRNA15980968
D002737ChloropreneChloroprene results in decreased expression of CD79A mRNA23125180
D003300CopperCopper deficiency results in increased expression of CD79A mRNA26033743
D016264Dextran SulfateDextran Sulfate results in increased expression of CD79A mRNA23894361
D004041Dietary FatsDietary Fats results in increased expression of CD79A mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of CD79A mRNA26033743
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CD79A mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of CD79A mRNA15465739
D005557FormaldehydeFormaldehyde results in decreased expression of CD79A mRNA23649840
C546771gardiquimodgardiquimod results in decreased expression of CD79A mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD79A mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of CD79A mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD79A mRNA22802445|2308692
C410337K 7174K 7174 results in increased expression of CD79A mRNA24086573
C008261lead acetatelead acetate results in decreased expression of CD79A mRNA22609695
D008727MethotrexateMethotrexate affects the expression of CD79A mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CD79A mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD79A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CD79A mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of CD79A mRNA16166746
C029341oxophenylarsineoxophenylarsine results in increased phosphorylation of CD79A protein8559152
D010126OzoneOzone results in decreased expression of CD79A mRNA12763052
C006253pirinixic acidpirinixic acid results in decreased expression of CD79A mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of CD79A mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of CD79A mRNA15465739
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD79A mRNA]28003376
D012834SilverSilver results in increased expression of CD79A mRNA27131904
C061133tamibarotenetamibarotene results in increased expression of CD79A mRNA17229644
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD79A mRNA22574217
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD79A mRNA20133372
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CD79A mRNA17982090
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CD79A mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of CD79A gene29154799
D014638VanadatesVanadates results in increased phosphorylation of CD79A protein8559152

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IMP14967045  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0030183B cell differentiation-IBA21873635  
GO:0030183B cell differentiation-ISS-  
GO:0042100B cell proliferation-ISS-  
GO:0042113B cell activation-ISS-  
GO:0050853B cell receptor signaling pathway-IBA21873635  
GO:0050853B cell receptor signaling pathway-ISS-  
GO:0051289protein homotetramerization-IMP14967045  
GO ID GO Term Qualifier Evidence PubMed
GO:0005771multivesicular body-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-ISS-  
GO:0019815B cell receptor complex-IBA21873635  
GO:0019815B cell receptor complex-ISS-  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
hsa04662B cell receptor signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-5690714CD22 mediated BCR regulationTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29448960Double-negative (CD27(-)IgD(-)) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations. (2018 Feb 15)Centuori SMJ Transl Med
15644129Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjogren's syndrome and healthy subjects. (2005 Jan)Larsson AScand J Immunol