Gene: HDAC9

9734
HD7|HD7b|HD9|HDAC|HDAC7|HDAC7B|HDAC9B|HDAC9FL|HDRP|MITR
histone deacetylase 9
protein-coding
7p21.1
Ensembl:ENSG00000048052 MIM:606543 Vega:OTTHUMG00000152487 UniprotKB:Q9UKV0
NG_023250.3
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.266e-1 (AD)  4.748e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIA40.912
SGTB0.907
MAGI10.906
TMEM650.906
SCAI0.903
LRRC8B0.902
PLCB10.901
OLFM30.9
CDH130.9
CNTN40.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.552
RNF135-0.513
HVCN1-0.513
RAB13-0.511
CHST14-0.502
SYDE1-0.5
ROM1-0.499
RHOD-0.499
HEBP2-0.496
AGTRAP-0.495

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB05015BelinostatSmall Molecule866323-14-0Approved|InvestigationalTarget
DB06603PanobinostatSmall Molecule404950-80-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HDAC9 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HDAC9 mRNA29067470
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]18098314
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HDAC9 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HDAC9 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HDAC9 mRNA24449571
D001599BerberineBerberine results in decreased expression of HDAC9 mRNA27311644
D001599BerberineBerberine results in increased expression of HDAC9 mRNA27311644
C006780bisphenol Abisphenol A results in decreased expression of HDAC9 mRNA22576693
C006780bisphenol Abisphenol A results in decreased expression of HDAC9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HDAC9 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HDAC9 mRNA27396813
D002737ChloropreneChloroprene results in decreased expression of HDAC9 mRNA23125180
C014347decitabinedecitabine results in decreased expression of HDAC9 mRNA27915011
D003703DemecolcineDemecolcine results in decreased expression of HDAC9 mRNA23649840
D003997DicarbethoxydihydrocollidineDicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA18098314
D003997DicarbethoxydihydrocollidineS-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]18098314
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of HDAC9 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of HDAC9 mRNA]27392435
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in decreased expression of HDAC9 mRNA"24200994
C118739entinostatentinostat results in decreased expression of HDAC9 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HDAC9 mRNA23649840
C056507gemcitabinegemcitabine results in increased expression of HDAC9 mRNA17039268
C004312glycidolglycidol results in decreased expression of HDAC9 mRNA24915197
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of HDAC9 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of HDAC9 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of HDAC9 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HDAC9 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HDAC9 mRNA23430699|2479639
C008261lead acetatelead acetate results in increased expression of HDAC9 mRNA20542052
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HDAC9 mRNA25890327
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HDAC9 mRNA26378955
D008694MethamphetamineMethamphetamine results in decreased expression of HDAC9 mRNA25452209
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HDAC9 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HDAC9 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HDAC9 mRNA"26251327
D016685MitomycinHDAC9 protein affects the susceptibility to Mitomycin16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HDAC9 mRNA23891734
C406082monomethylarsonous acidvorinostat inhibits the reaction [monomethylarsonous acid results in increased expression of HDAC9 mRNA]23891734
D009151Mustard GasMustard Gas results in decreased expression of HDAC9 mRNA26392148
D017239PaclitaxelHDAC9 protein results in increased susceptibility to Paclitaxel16734730
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HDAC9 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of HDAC9 mRNA25119042
D011441PropylthiouracilPropylthiouracil results in increased expression of HDAC9 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of HDAC9 mRNA22300531|2535159
D012834SilverSilver results in decreased expression of HDAC9 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of HDAC9 mRNA16966095
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HDAC9 mRNA26378955
C016766sulforafansulforafan results in decreased expression of HDAC9 mRNA26833863
D014284TriiodothyronineTriiodothyronine results in increased expression of HDAC9 mRNA17399805
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HDAC9 mRNA20189893
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of HDAC9 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HDAC9 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HDAC9 mRNA22493514
D019772TopotecanHDAC9 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of HDAC9 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of HDAC9 mRNA22723015|2493525
C012589trichostatin Atrichostatin A results in decreased activity of HDAC9 protein25699604
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of HDAC9 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of HDAC9 mRNA23179753|2718838
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]19225232
D014638VanadatesVanadates results in increased expression of HDAC9 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HDAC9 gene25487561
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HDAC9 gene25560391
D014750VincristineVincristine results in decreased expression of HDAC9 mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA"27188386
C111237vorinostatvorinostat inhibits the reaction [monomethylarsonous acid results in increased expression of HDAC9 mRNA]23891734
C111237vorinostatvorinostat results in increased expression of HDAC9 mRNA27188386
C111237vorinostatvorinostat results in decreased activity of HDAC9 protein17988634
C088658zoledronic acidzoledronic acid results in increased expression of HDAC9 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-ISS-  
GO:0004407histone deacetylase activity-IDA11535832  
GO:0005080protein kinase C binding-IPI20188095  
GO:0005515protein binding-IPI12590135  16147992  
GO:0008134transcription factor binding-IDA11535832  
GO:0008134transcription factor binding-IPI10748098  15567413  19303849  
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)-IEA-  
GO:0033558protein deacetylase activity-IDA11535832  
GO:0042826histone deacetylase binding-IPI12590135  
GO:0046872metal ion binding-IEA-  
GO:0070491repressing transcription factor binding-IDA12590135  
GO:0070491repressing transcription factor binding-IPI17360565  
GO:0070491repressing transcription factor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10655483  11535832  
GO:0001975response to amphetamine-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006954inflammatory response-TAS12711221  
GO:0007507heart development-ISS-  
GO:0016575histone deacetylation-IDA11535832  
GO:0030182neuron differentiation-IEA-  
GO:0030183B cell differentiation-TAS12711221  
GO:0032869cellular response to insulin stimulus-IDA19303849  
GO:0034983peptidyl-lysine deacetylation-IDA11535832  
GO:0042113B cell activation-TAS12711221  
GO:0045892negative regulation of transcription, DNA-templated-IDA11535832  
GO:0048742regulation of skeletal muscle fiber development-ISS-  
GO:0051153regulation of striated muscle cell differentiation-ISS-  
GO:0070932histone H3 deacetylation-IDA12590135  
GO:0070933histone H4 deacetylation-IDA12590135  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IMP19351956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-TAS12711221  
GO:0005634nucleus-IDA12590135  20188095  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA15567413  19303849  
GO:0005737cytoplasm-IDA12590135  20188095  
GO:0005737cytoplasm-TAS12711221  
GO:0035097histone methyltransferase complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18549475Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. (2008 Jun 12)Blons HBMC Med Genomics
22776031Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke. (2012 Jul 9)Hacke WBMC Med
24650256SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women. (2014 Mar 21)Lai LCJ Biomed Sci