Gene: USP34

9736
-
ubiquitin specific peptidase 34
protein-coding
2p15
Ensembl:ENSG00000115464 MIM:615295 Vega:OTTHUMG00000152265 UniprotKB:Q70CQ2
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.711e-1 (AD)  3.059e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs778139chr2:61457429 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA20260.913
SPIRE10.905
DDX60.888
RSF10.879
WDFY30.878
BPTF0.876
TAOK10.863
GIGYF20.863
RBM410.86
USP320.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.477
OR4F5-0.464
APOA1-0.289
HMX1-0.289
FAM229A-0.283
NANOGNB-0.266
S100A1-0.261
MUC12-0.259
S100A14-0.255
PLA2G5-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of USP34 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP34 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP34 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of USP34 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of USP34 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of USP34 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of USP34 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of USP34 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USP34 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of USP34 mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of USP34 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of USP34 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP34 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of USP34 mRNA24982889
D002922CiguatoxinsCiguatoxins affects the expression of USP34 mRNA18353800
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of USP34 mRNA23640034
D003703DemecolcineDemecolcine results in increased expression of USP34 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of USP34 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP34 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of USP34 mRNA27594783
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of USP34 mRNA22079256
D000431EthanolEthanol results in decreased expression of USP34 mRNA29018328
D005557FormaldehydeFormaldehyde results in decreased expression of USP34 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of USP34 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP34 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP34 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of USP34 mRNA27392435
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA22839698
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of USP34 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of USP34 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of USP34 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of USP34 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of USP34 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of USP34 mRNA"20188158|2625132
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of USP34 mRNA"29244179
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of USP34 mRNA25729387
D010795Phthalic AcidsPhthalic Acids results in increased expression of USP34 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of USP34 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of USP34 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of USP34 mRNA23608068
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of USP34 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of USP34 mRNA26378955
C004648testosterone enanthatetestosterone enanthate affects the expression of USP34 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USP34 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USP34 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USP34 mRNA21215274
D013849ThimerosalThimerosal affects the expression of USP34 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of USP34 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of USP34 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of USP34 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of USP34 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of USP34 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of USP34 mRNA17127020
D014635Valproic AcidValproic Acid results in decreased expression of USP34 mRNA23179753|2519280
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of USP34 gene25560391
D014750VincristineVincristine results in increased expression of USP34 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of USP34 mRNA27188386
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0004197cysteine-type endopeptidase activity-IMP21383061  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IBA21873635  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA14715245  21383061  
GO:0005515protein binding-IPI21383061  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-IDA21383061  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0016055Wnt signaling pathway-TAS-  
GO:0016579protein deubiquitination-IBA21873635  
GO:0016579protein deubiquitination-IDA14715245  
GO:0016579protein deubiquitination-TAS-  
GO:0031647regulation of protein stability-IBA21873635  
GO:0071108protein K48-linked deubiquitination-IDA21383061  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA21383061  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal