Gene: PHACTR2

9749
C6orf56
phosphatase and actin regulator 2
protein-coding
6q24.2
Ensembl:ENSG00000112419 MIM:608724 Vega:OTTHUMG00000015732 UniprotKB:O75167
NC_000006.12
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.677e-1 (AD)  1.768e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6931825chr6:143758651 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9390132chr6:143740552 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs960710chr6:143739821 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRIP10.794
VTI1A0.783
NCOA30.779
RBM270.774
LNPEP0.772
PIK3CA0.767
WDFY10.766
ZBTB380.766
SLMAP0.764
BMPR20.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.42
OR4F29-0.39
NRN1L-0.31
S100A1-0.297
SLC25A48-0.282
APOA1-0.281
FAM229A-0.266
APOA4-0.245
DRD4-0.236
SEPT1-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHACTR2 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PHACTR2 mRNA"20702594
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHACTR2 mRNA"19167446
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PHACTR2 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PHACTR2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PHACTR2 mRNA17562736
D001280AtrazineAtrazine results in decreased expression of PHACTR2 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of PHACTR2 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHACTR2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHACTR2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHACTR2 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PHACTR2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of PHACTR2 mRNA28196854
C006780bisphenol Abisphenol A results in decreased expression of PHACTR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PHACTR2 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of PHACTR2 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PHACTR2 mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PHACTR2 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of PHACTR2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PHACTR2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PHACTR2 mRNA27339419
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHACTR2 mRNA19320972
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHACTR2 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of PHACTR2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of PHACTR2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PHACTR2 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of PHACTR2 mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PHACTR2 mRNA21266533
D004237DiuronDiuron results in decreased expression of PHACTR2 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHACTR2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHACTR2 mRNA28196854
D005485FlutamideFlutamide results in decreased expression of PHACTR2 mRNA21126777
C001277geldanamycingeldanamycin results in increased expression of PHACTR2 mRNA26705709
D017313FenretinideFenretinide results in decreased expression of PHACTR2 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of PHACTR2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of PHACTR2 mRNA22609695
C045463leflunomideleflunomide results in increased expression of PHACTR2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PHACTR2 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PHACTR2 mRNA25613284
D008727MethotrexatePHACTR2 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PHACTR2 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PHACTR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHACTR2 mRNA"25554681
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PHACTR2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHACTR2 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHACTR2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PHACTR2 mRNA22079256|2271453
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PHACTR2 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of PHACTR2 mRNA21632981
D012643SeleniumSelenium results in decreased expression of PHACTR2 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of PHACTR2 mRNA21795629
C016766sulforafansulforafan results in increased expression of PHACTR2 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHACTR2 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PHACTR2 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of PHACTR2 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PHACTR2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PHACTR2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PHACTR2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHACTR2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PHACTR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PHACTR2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of PHACTR2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PHACTR2 mRNA28001369
C025643vinclozolinvinclozolin affects the expression of PHACTR2 mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of PHACTR2 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PHACTR2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0004864protein phosphatase inhibitor activity-IEA-  
GO:0005515protein binding-IPI17474147  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0031092platelet alpha granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23108145Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer. (2013 Jan 1)Wang LECancer Res