Gene: CD81

975
CVID6|S5.7|TAPA1|TSPAN28
CD81 molecule
protein-coding
11p15.5
Ensembl:ENSG00000110651 MIM:186845 Vega:OTTHUMG00000009892 UniprotKB:P60033
NG_023386.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.107e-1 (AD)  2.093e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLU0.941
ITM2C0.915
ECH10.909
FYN0.908
TMBIM60.907
CYB5R30.901
CSTB0.898
HADHA0.894
DAD10.892
ZFAND30.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.796
OR4F29-0.768
CETP-0.219
OR6C74-0.209
TYRP1-0.208
ZNF860-0.2
CDH7-0.194
PCDHAC1-0.187
FER1L6-0.187
HS6ST3-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CD81 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CD81 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD81 mRNA"15215175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD81 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CD81 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CD81 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD81 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD81 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD81 mRNA22228805
D004958EstradiolEstradiol results in increased expression of CD81 mRNA19693291
C006780bisphenol Abisphenol A affects the expression of CD81 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CD81 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CD81 mRNA28628672
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CD81 mRNA12082028
D002392CatechinCatechin results in increased expression of CD81 mRNA15465739
C100187chloropicrinchloropicrin results in decreased expression of CD81 mRNA26352163
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of CD81 mRNA21356183
D003042CocaineCD81 protein results in increased susceptibility to Cocaine15715673
D003042CocaineCD81 protein affects the susceptibility to Cocaine12113778
D003042CocaineCocaine results in increased expression of CD81 mRNA12113778
D003042CocaineCD81 protein results in increased susceptibility to Cocaine15715673
D003042CocaineCocaine results in increased expression of CD81 mRNA11178868
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of CD81 mRNA21356183
C009160cyclonitecyclonite results in decreased expression of CD81 mRNA19417177
D016572CyclosporineCyclosporine results in decreased expression of CD81 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CD81 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of CD81 mRNA21041162
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D002945CisplatinCisplatin results in increased expression of CD81 protein22023808
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D004041Dietary FatsDietary Fats results in increased expression of CD81 mRNA15238619
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD81 mRNA21041162
D004317DoxorubicinDoxorubicin affects the expression of CD81 protein29385562
D004391DustDust results in decreased expression of CD81 mRNA17805423
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D000431EthanolEthanol results in increased expression of CD81 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD81 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CD81 mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD81 mRNA12082028
D005419FlavonoidsFlavonoids results in increased expression of CD81 mRNA15465739
D005485FlutamideFlutamide results in decreased expression of CD81 mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of CD81 mRNA16221962
D005839GentamicinsGentamicins results in increased expression of CD81 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CD81 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CD81 mRNA28628672
D007854LeadLead affects the expression of CD81 mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D008727MethotrexateMethotrexate results in increased expression of CD81 mRNA17400583
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CD81 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CD81 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CD81 mRNA23103053
C059539midostaurinmidostaurin results in decreased expression of CD81 mRNA20980353
C568376MT19c compoundMT19c compound results in decreased expression of CD81 mRNA21781307
C051752nefazodonenefazodone results in decreased expression of CD81 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of CD81 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CD81 mRNA17616710
C025589ochratoxin Aochratoxin A results in increased acetylation of CD81 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of CD81 promoter] which results in increased expression of CD81 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of CD81 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD81 mRNA25729387
D010634PhenobarbitalPhenobarbital results in decreased expression of CD81 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of CD81 mRNA12082028
D010936Plant ExtractsPlant Extracts results in decreased expression of CD81 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CD81 mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of CD81 mRNA15465739
D011192Potassium DichromatePotassium Dichromate results in increased expression of CD81 protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CD81 mRNA19162173
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892
D015474IsotretinoinIsotretinoin results in increased expression of CD81 mRNA20436886
D012402RotenoneRotenone results in increased expression of CD81 mRNA25682864
D012402RotenoneRotenone results in increased expression of CD81 protein25682864
C017947sodium arsenitesodium arsenite results in increased expression of CD81 mRNA20308225
D013739TestosteroneTestosterone results in decreased expression of CD81 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD81 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD81 mRNA18796159|2821309
D013849ThimerosalThimerosal results in decreased expression of CD81 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD81 mRNA25729387
C406224valdecoxibvaldecoxib results in decreased expression of CD81 mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of CD81 gene29154799
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA25607892

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IMP20375010  
GO:0005178integrin binding-IDA27993971  
GO:0005515protein binding-IPI2398277  9168119  9794763  10400713  11504738  12522210  
12604806  14676841  19088272  20375010  21930792  26808496  
GO:0023026MHC class II protein complex binding-HDA20458337  
GO:1990459transferrin receptor binding-IPI25635054  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA14676841  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0008104protein localization-IDA14676841  
GO:0008283cell proliferation-TAS1695320  
GO:0008284positive regulation of cell proliferation-IDA14676841  
GO:0030449regulation of complement activation-TAS-  
GO:0030890positive regulation of B cell proliferation-IDA10400713  
GO:0031623receptor internalization-ISS-  
GO:0031647regulation of protein stability-IMP25635054  
GO:0043128positive regulation of 1-phosphatidylinositol 4-kinase activity-IDA14676841  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI25635054  
GO:0046718viral entry into host cell-TAS14676841  
GO:0046813receptor-mediated virion attachment to host cell-TAS14676841  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA14676841  
GO:0050776regulation of immune response-TAS-  
GO:0061462protein localization to lysosome-IMP25635054  
GO:0071404cellular response to low-density lipoprotein particle stimulus-ISS-  
GO:1904352positive regulation of protein catabolic process in the vacuole-IMP25635054  
GO:2000145regulation of cell motility-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IDA21930792  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA14676841  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0016323basolateral plasma membrane-IDA20375010  
GO:0031982vesicle-IDA9360996  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0070062extracellular exosome-IDA15908444  19028452  21235781  21276792  
KEGG ID KEGG Term
hsa04662B cell receptor signaling pathway
hsa05144Malaria
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18662991Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. (2008 Sep 19)Takeda YJ Biol Chem